NS-2359
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| Formula | C15H19Cl2NO |
| Molar mass | 300.22g·mol−1 |
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NS-2359(GSK-372475) is aserotonin-norepinephrine-dopamine reuptake inhibitor.It was underdevelopmentbyGlaxoSmithKline(GSK) as anantidepressant,[1]but was discontinued in 2009 whenphase IIclinical trialsshowed the drug was not effective and not well tolerated.[2]The results did not support further effort by the company.[1]NS-2359 was also in clinical trials for thetreatmentofADHD,[3]phase II having been completed in 2007.[4]Aphase I clinical trialexploring the effect of NS-2359 oncocaine-dependentindividuals was completed in 2002.[5]
See also[edit]
References[edit]
- ^ab"NeuroSearch announces the results of Phase II Proof of Concept studies with NS2359 in depression".NeuroSearch.Archivedfrom the original on 2016-03-04.Retrieved2009-06-20.
- ^Learned S, Graff O, Roychowdhury S, Moate R, Krishnan KR, Archer G, Modell JG, Alexander R, Zamuner S, Lavergne A, Evoniuk G, Ratti E (May 2012). "Efficacy, safety, and tolerability of a triple reuptake inhibitor GSK372475 in the treatment of patients with major depressive disorder: two randomized, placebo- and active-controlled clinical trials".Journal of Psychopharmacology.26(5): 653–62.doi:10.1177/0269881111424931.PMID22048884.S2CID9365152.
- ^Wilens TE, Klint T, Adler L, West S, Wesnes K, Graff O, Mikkelsen B (June 2008)."A randomized controlled trial of a novel mixed monoamine reuptake inhibitor in adults with ADHD".Behavioral and Brain Functions.4:24.doi:10.1186/1744-9081-4-24.PMC2442604.PMID18554401.
- ^Clinical trial numberNCT00467428for "Efficacy and Safety of NS2359 in Adults With Attention Deficit Hyperactivity Disorder" atClinicalTrials.gov
- ^Clinical trial numberNCT00032916for "Interaction Study With NS2359 and Cocaine in Cocaine Experienced Volunteers" atClinicalTrials.gov
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