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Nancy Allbritton

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Nancy Allbritton
NationalityAmerican
Alma materLouisiana State University(BS)
Johns Hopkins University(MD)
Massachusetts Institute of Technology(PhD)
Known forSingle-cell analysis
Scientific career
FieldsBiomedical Engineering
InstitutionsUniversity of WashingtonUniversity of North Carolina at Chapel HillandNorth Carolina State University

Nancy Allbrittonis a Professor of Bioengineering and the Frank & Julie Jungers Dean of the College of Engineering at theUniversity of Washington.[1]She was previously a Kenan Professor and Chair in the Joint Department of Biomedical Engineering at theUniversity of North Carolina at Chapel HillandNorth Carolina State University.[2]

She is best known for her work in single-cell analysis. Using engineering methods, Allbritton creates tools for better understanding and manipulating living cells and tissues. Microengineered platforms, microfluidics, and novel biochemical assays enable scientists to studycell signalingandsignal transductionat the single-cell level.[3]

Education

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Allbritton received abachelor of sciencewith a major in physics fromLouisiana State University, Baton Rougein 1979. She received adoctor of medicinefromJohns Hopkins Universityin 1985 and adoctor of philosophyin medical physics and medical engineering from theMassachusetts Institute of Technologyin 1987.[4]

Career

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Allbritton was apostdoctoral fellowatStanford Universityfrom 1989 to 1994.[5]She then became a Professor at theUniversity of California at Irvine,teaching in the departments of Physiology and Biophysics, Biomedical Engineering, Chemistry, Chemical Engineering and Materials Science. She remained at UC Irvine for 13 years, from 1994-2007.[5]

In 2007 Allbritton joined theUniversity of North Carolina at Chapel Hill,becoming a Kenan Distinguished Professor. From 2009-2019 she was the Chair of the Joint Department of Biomedical Engineering at the University of North Carolina at Chapel Hill andNorth Carolina State University.[2] She has held faculty appointments in Chemistry, Pharmacology and Applied Physical Sciences at UNC, and in the Department of Materials Science and Engineering at NC State.[6]

As of November 1, 2019, Allbritton became a Professor of Bioengineering and the Frank & Julie Jungers Dean of Engineering at theUniversity of WashingtonCollege of Engineering.[7][1]

Allbritton was appointed a co-editorof theAnnual Review of Analytical Chemistryin 2021.[8]

Research interests

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Allbritton's interest in single-cell analysis have hinged on the use ofcapillary electrophoresis(CE) and microfabricated technologies. Through this work she has studied lipid signaling at the single-cell level, the isolation cytotoxic t-cells with specific properties, and the capture of colonic crypts. In theorgan-on-a-chipfield,[9]Allbritton has used fabrication technologies fromelectronicsandmicrofluidicsto develop devices that effectively recreate the environment of both the small andlarge intestine.[10][11]These include micrototal analysis systems[12][13]andmicroraftarrays.[14]In the area ofdielectrophoresis(DEP), Allbritton's lab works on the transfer of DEP-based systems out of laboratories and into clinical use.[15]

Awards

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Patents

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  • "Fast controllable laser lysis of cells for analysis" Nancy L. Allbritton, Christopher E. Sims, Michael W. Berns, Gavin D. Meredith, Tatiana B. Krasieva, Bruce J. Tromberg U.S. Patent No. US6156576A
  • "Method and apparatus for detecting enzymatic activity using molecules that change electrophoretic mobility" Nancy L. Allbritton, Christopher E. Sims, Michael W. Berns, Gavin D. Meredith, Tatiana B. Krasieva, Bruce J. Tromberg U.S. Patent No. 6335201B1
  • "Method to measure the activation state of signaling pathways in cells" Nancy Allbritton, Christopher Sims U.S. Patent No. 7236888B2
  • "Chemical modifications to polymer surfaces and the application of polymer grafting to biomaterials" Nancy Allbritton, Christopher Sims, Guann-Pyng Li, Mark Bachman, Shuwen Hu, Xueqin Ren U.S. Patent No. 20050237480A1
  • "Systems and methods for efficient collection of single cells and colonies of cells and fast generation of stable transfectants" Nancy Allbritton, Christopher E. Sims, Yuli Wang, Mark Bachman, Guann-Pyng Li, Eric Stanbridge U.S. Patent No. 7759119B2
  • "Method and device for cell selection and collection in an isolated culturing environment" Nancy Allbritton, Christopher Sims, Wei Xu U.S. Patent No. 20110294208A1
  • "Array of micromolded structures for sorting adherent cells" Nancy Allbritton, Christopher Sims, Yuli Wang, Pavak Kirit Shah U.S. Patent No. 9068155B2

References

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  1. ^abHoltz August 13, 2019, Jackson (August 13, 2019)."Dr. Nancy Allbritton named dean of UW's College of Engineering".UW News.Retrieved2020-06-24.{{cite web}}:CS1 maint: numeric names: authors list (link)
  2. ^ab"Meet the Team | Single-Cell Isolation and Recovery".Cellmicrosystems.com.Retrieved2017-05-01.
  3. ^"Distinguished Seminar Series: Nancy Allbritton, Professor and Chair Department of Biomedical Engineering University of North Carolina & North Carolina State University".UCDavis Biomedical Engineering.October 30, 2014.Retrieved2 August2018.
  4. ^"Nancy Allbritton | UW Bioengineering".2020-04-27.Retrieved2022-10-06.
  5. ^ab"Nancy Allbritton".College of Engineering.University of Washington.Retrieved8 September2021.
  6. ^Lancaster, Brent (August 23, 2019)."Allbritton leaving Joint Department of Biomedical Engineering".College of Engineering News.NC State University.Retrieved8 September2021.
  7. ^"Nancy L. Allbritton".American Institute of Chemical Engineers.26 May 2020.Retrieved8 September2021.
  8. ^"Annual Review of Analytical Chemistry, Current Editorial Committee".Annual Reviews.Retrieved9 July2021.
  9. ^Ma, Chao; Peng, Yansong; Li, Hongtong; Chen, Weiqiang (February 2021)."Organ-on-a-Chip: A New Paradigm for Drug Development".Trends in Pharmacological Sciences.42(2): 119–133.doi:10.1016/j.tips.2020.11.009.ISSN0165-6147.PMC7990030.PMID33341248.
  10. ^Landhuis, Esther (26 September 2019)."Microbial chemistry gains fresh focus".Nature.573(7775): 615–616.Bibcode:2019Natur.573..615L.doi:10.1038/d41586-019-02853-5.PMID31551561.
  11. ^"Researchers awarded $5.3 million to develop novel gut-on-a-chip technology".UNC College of Arts & Sciences.October 12, 2015.Retrieved8 September2021.
  12. ^Zhuang, Jianjian; Yin, Juxin; Lv, Shaowu; Wang, Ben; Mu, Ying (September 2020)."Advanced" lab-on-a-chip "to detect viruses – Current challenges and future perspectives".Biosensors and Bioelectronics.163:112291.doi:10.1016/j.bios.2020.112291.PMC7215165.PMID32421630.
  13. ^Kovarik, Michelle L.; Ornoff, Douglas M.; Melvin, Adam T.; Dobes, Nicholas C.; Wang, Yuli; Dickinson, Alexandra J.; Gach, Philip C.; Shah, Pavak K.; Allbritton, Nancy L. (15 January 2013)."Micro Total Analysis Systems: Fundamental Advances and Applications in the Laboratory, Clinic, and Field".Analytical Chemistry.85(2): 451–472.doi:10.1021/ac3031543.PMC3546124.PMID23140554.
  14. ^Smiddy, Nicole M.; DiSalvo, Matthew; Allbritton-King, Jules D.; Allbritton, Nancy L. (2020)."Microraft array-based platform for sorting of viable microcolonies based on cell-lethal immunoassay of intracellular proteins in microcolony biopsies".The Analyst.145(7): 2649–2660.Bibcode:2020Ana...145.2649S.doi:10.1039/D0AN00030B.PMC7117799.PMID32048684.
  15. ^Çağlayan, Zeynep; Demircan Yalçın, Yağmur; Külah, Haluk (3 November 2020)."A Prominent Cell Manipulation Technique in BioMEMS: Dielectrophoresis".Micromachines.11(11): 990.doi:10.3390/mi11110990.PMC7693018.PMID33153069.
  16. ^"Nancy Allbritton".UNC Lineberger.Retrieved8 September2021.
  17. ^"Searle Scholars Program: Nancy L. Allbritton (1995)".searlescholars.net.Retrieved2019-04-19.
  18. ^"Nancy Allbritton".Arnold and Mabel Beckman Foundation.Archived fromthe originalon 2 August 2018.Retrieved1 August2018.
  19. ^"Academic Senate - Irvine Division - Committee on Scholarly Honors and Awards"(PDF).University of California, Irvine.Retrieved8 September2021.
  20. ^"Nancy Allbritton".UNC Lineberger.RetrievedApril 12,2017.
  21. ^"NIH Director's Transformative Research Award Recipients 2015 Awardees".National Institutes of Health.18 September 2018.Retrieved8 September2021.
  22. ^"Chemical Instrumentation".ACS Division of Analytical Chemistry.12 July 2017.Retrieved8 September2021.
  23. ^"Edward Kidder Graham Faculty Service Award".Office of Faculty Governance at the University of North Carolina at Chapel Hill.Retrieved8 September2021.
  24. ^"Allbritton named 2017 UNC-Chapel Hill Inventor of the Year".UNC College of Arts & Sciences.June 16, 2017.Retrieved8 September2021.
  25. ^Delonas, Cindy (February 27, 2020)."Nancy L. Allbritton Wins Ralph N. Adams Award".LCGC.Retrieved8 September2021.
  26. ^"BME Chair Emeritus Nancy Allbritton to Receive 2021 Pritzker Distinguished Lecture Award".Joint Department of Biomedical Engineering.University of North Carolina, North Carolina State University. May 14, 2021.Retrieved8 September2021.
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