Hydroxycarboxylic acid receptor 3

HCAR3
Identifiers
Aliases	HCAR3,GPR109B, HCA3, HM74, PUMAG, Puma-g, Niacin receptor 2, hydroxycarboxylic acid receptor 3
External IDs	OMIM:606039;MGI:1933383;HomoloGene:130547;GeneCards:HCAR3;OMA:HCAR3 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q24.31 Start 122,714,756bp End 122,716,811bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 F Start 124,001,633bp End 124,003,562bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in blood granulocyte gonad spleen monocyte mucosa of esophagus bone marrow skin of abdomen skin of leg appendix Top expressed in granulocyte esophagus lip skin of external ear morula subcutaneous adipose tissue skin of back transitional epithelium of urinary bladder trachea skin of abdomen More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity Cellular component integral component of membrane cell junction plasma membrane integral component of plasma membrane membrane Biological process G protein-coupled receptor signaling pathway signal transduction Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 8843 80885 Ensembl ENSG00000255398 ENSMUSG00000045502 UniProt P49019 Q9EP66 RefSeq (mRNA) NM_006018 NM_030701 RefSeq (protein) NP_006009 NP_109626 Location (UCSC) Chr 12: 122.71 – 122.72 Mb Chr 5: 124 – 124 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

Hydroxycarboxylic acid receptor 3(HCA₃), also known asniacin receptor 2(NIACR2) andGPR109B,is aproteinwhich in humans is encoded by theHCAR3gene.HCA₃,like the otherhydroxycarboxylic acid receptorsHCA₁andHCA₂,is aG_i/o-coupledG protein-coupled receptor(GPCR).The primaryendogenousagonistsof HCA₃are3-hydroxyoctanoic acidandkynurenic acid.HCA₃is also alow-affinitybiomolecular targetforniacin(aka nicotinic acid).

Further reading

• Nomura H, Nielsen BW, Matsushima K (October 1993). "Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors".International Immunology.5(10): 1239–1249.doi:10.1093/intimm/5.10.1239.PMID7505609.
• Zingoni A, Rocchi M, Storlazzi CT, Bernardini G, Santoni A, Napolitano M (June 1997). "Isolation and chromosomal localization of GPR31, a human gene encoding a putative G protein-coupled receptor".Genomics.42(3): 519–523.doi:10.1006/geno.1997.4754.hdl:11573/245592.PMID9205127.
• Irobi J, Nelis E, Verhoeven K, De Vriendt E, Dierick I, De Jonghe P, et al. (June 2002). "Mutation analysis of 12 candidate genes for distal hereditary motor neuropathy type II (distal HMN II) linked to 12q24.3".Journal of the Peripheral Nervous System.7(2): 87–95.doi:10.1046/j.1529-8027.2002.02014.x.PMID12090300.S2CID8453412.
• Wise A, Foord SM, Fraser NJ, Barnes AA, Elshourbagy N, Eilert M, et al. (March 2003)."Molecular identification of high and low affinity receptors for nicotinic acid".The Journal of Biological Chemistry.278(11): 9869–9874.doi:10.1074/jbc.M210695200.PMID12522134.
• Tunaru S, Kero J, Schaub A, Wufka C, Blaukat A, Pfeffer K, et al. (March 2003). "PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect".Nature Medicine.9(3): 352–355.doi:10.1038/nm824.PMID12563315.S2CID20451806.
• Soga T, Kamohara M, Takasaki J, Matsumoto S, Saito T, Ohishi T, et al. (March 2003). "Molecular identification of nicotinic acid receptor".Biochemical and Biophysical Research Communications.303(1): 364–369.doi:10.1016/S0006-291X(03)00342-5.PMID12646212.
• Toulza E, Mattiuzzo NR, Galliano MF, Jonca N, Dossat C, Jacob D, et al. (2007)."Large-scale identification of human genes implicated in epidermal barrier function".Genome Biology.8(6): R107.doi:10.1186/gb-2007-8-6-r107.PMC2394760.PMID17562024.

External links

• "Nicotinic Acid Receptor Family: GPR109B".IUPHAR Database of Receptors and Ion Channels.International Union of Basic and Clinical Pharmacology. Archived fromthe originalon 2016-03-03.Retrieved2008-12-09.