Nitrosourea
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| IUPAC name
Nitrosourea
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| Identifiers | |||
3D model (JSmol)
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PubChemCID
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| UNII | |||
CompTox Dashboard(EPA)
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| Properties | |||
| CH3N3O2 | |||
| Molar mass | 89.054g·mol−1 | ||
Except where otherwise noted, data are given for materials in theirstandard state(at 25 °C [77 °F], 100 kPa).
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Nitrosoureais both the name of a molecule, and a class of compounds that include anitroso(R-NO) group and aurea.
Examples
[edit]Examples include:
- Arabinopyranosyl-N-methyl-N-nitrosourea(Aranose)
- Carmustine(BCNU, BiCNU)
- Chlorozotocin
- Ethylnitrosourea(ENU)
- Fotemustine
- Lomustine(CCNU)
- Nimustine
- N-Nitroso-N-methylurea(NMU)
- Ranimustine(MCNU)
- Semustine
- Streptozocin(Streptozotocin)
Nitrosourea compounds areDNAalkylating agentsand are often used inchemotherapy.[1]They arelipophilicand thus can cross theblood–brain barrier,making them useful in the treatment ofbrain tumorssuch asglioblastoma multiforme.[2]
Side effects
[edit]Some nitrosoureas (e.g. lomustine) have been associated with the development ofinterstitial lung disease.[3]
References
[edit]- ^"Antineop".Archived fromthe originalon 2009-03-07.Retrieved2009-01-24.
- ^Takimoto CH, Calvo E."Principles of oncologic pharmacotherapy".in Pazdur R, Wagman LD, Camphausen KA, Hoskins WJ (Eds)Cancer management: a multidisciplinary approach.11 ed. 2008.
- ^Tucci E, Verdiani P, Di Carlo S, Sforza V (1986). "Lomustine (CCNU)-induced pulmonary fibrosis".Tumori.72(1): 95–8.doi:10.1177/030089168607200114.PMID3952821.S2CID33327504.
External links
[edit]- Nitrosourea+Compoundsat the U.S. National Library of MedicineMedical Subject Headings(MeSH)
- Diseases Database(DDB):9052
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