OPN1MW

OPN1MW
Identifiers
Aliases	OPN1MW,CBBM, CBD, COD5, GCP, GOP, OPN1MW1, opsin 1 (cone pigments), medium-wave-sensitive, opsin 1, medium wave sensitive
External IDs	OMIM:300821;MGI:1097692;HomoloGene:88332;GeneCards:OPN1MW;OMA:OPN1MW - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xq28 Start 154,182,596bp End 154,196,861bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X A7.3 Start 73,171,070bp End 73,194,366bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in testicle appendix blood urinary bladder myometrium left adrenal cortex coronary artery left coronary artery right auricle stomach Top expressed in neural layer of retina muscle of thigh retinal pigment epithelium epithelium of lens embryo outer nuclear layer knee joint soleus muscle skeletal muscle tissue quadriceps femoris muscle More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity photoreceptor activity signal transducer activity G protein-coupled photoreceptor activity identical protein binding Cellular component integral component of membrane plasma membrane membrane photoreceptor outer segment integral component of plasma membrane photoreceptor disc membrane Biological process positive regulation of cytokinesis signal transduction visual perception retinoid metabolic process response to stimulus G protein-coupled receptor signaling pathway phototransduction detection of visible light cellular response to light stimulus Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 2652 14539 Ensembl ENSG00000268221 ENSMUSG00000031394 UniProt P04001 P0DN77 P0DN78 O35599 RefSeq (mRNA) NM_000513 NM_008106 RefSeq (protein) NP_001316996 NP_000504 NP_001041646 NP_000504.1 NP_001041646.1 NP_000504 NP_001041646 NP_000504.1 NP_001041646.1 NP_000504 NP_001041646 NP_032132 Location (UCSC) Chr X: 154.18 – 154.2 Mb Chr X: 73.17 – 73.19 Mb PubMedsearch
Wikidata
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Green-sensitive opsinis aproteinthat in humans is encoded by theOPN1MWgene. OPN1MW2is a similar opsin.

See also

• Opsin

Further reading

• Applebury ML, Hargrave PA (1987). "Molecular biology of the visual pigments".Vision Res.26(12): 1881–95.doi:10.1016/0042-6989(86)90115-X.PMID3303660.S2CID34038855.
• Winderickx J, Sanocki E, Lindsey DT, et al. (1993). "Defective colour vision associated with a missense mutation in the human green visual pigment gene".Nat. Genet.1(4): 251–6.doi:10.1038/ng0792-251.PMID1302020.S2CID23127406.
• Neitz J, Neitz M, Jacobs GH (1990). "Analysis of fusion gene and encoded photopigment of colour-blind humans".Nature.342(6250): 679–82.doi:10.1038/342679a0.PMID2574415.S2CID4273929.
• Nathans J, Thomas D, Hogness DS (1986). "Molecular genetics of human color vision: the genes encoding blue, green, and red pigments".Science.232(4747): 193–202.Bibcode:1986Sci...232..193N.CiteSeerX10.1.1.461.5915.doi:10.1126/science.2937147.PMID2937147.
• Li ZY, Kljavin IJ, Milam AH (1995)."Rod photoreceptor neurite sprouting in retinitis pigmentosa".J. Neurosci.15(8): 5429–38.doi:10.1523/JNEUROSCI.15-08-05429.1995.PMC6577619.PMID7643192.
• Ladekjaer-Mikkelsen AS, Rosenberg T, Jørgensen AL (1996). "A new mechanism in blue cone monochromatism".Hum. Genet.98(4): 403–8.doi:10.1007/s004390050229.PMID8792812.S2CID11799731.
• Ferreira PA, Nakayama TA, Pak WL, Travis GH (1996). "Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin".Nature.383(6601): 637–40.Bibcode:1996Natur.383..637F.doi:10.1038/383637a0.PMID8857542.S2CID4304490.
• Vissers PM, Bovee-Geurts PH, Portier MD, et al. (1998)."Large-scale production and purification of the human green cone pigment: characterization of late photo-intermediates".Biochem. J.330(3): 1201–8.doi:10.1042/bj3301201.PMC1219262.PMID9494086.
• Bernstein SL, Wong P (1998). "Regional expression of disease-related genes in human and monkey retina".Mol. Vis.4:24.PMID9815288.
• Hayashi T, Motulsky AG, Deeb SS (1999). "Position of a 'green-red' hybrid gene in the visual pigment array determines colour-vision phenotype".Nat. Genet.22(1): 90–3.doi:10.1038/8798.PMID10319869.S2CID1326234.
• Ueyama H, Kuwayama S, Imai H, et al. (2002). "Novel missense mutations in red/green opsin genes in congenital color-vision deficiencies".Biochem. Biophys. Res. Commun.294(2): 205–9.doi:10.1016/S0006-291X(02)00458-8.PMID12051694.
• Zhu X, Brown B, Li A, et al. (2003)."GRK1-dependent phosphorylation of S and M opsins and their binding to cone arrestin during cone phototransduction in the mouse retina".J. Neurosci.23(14): 6152–60.doi:10.1523/JNEUROSCI.23-14-06152.2003.PMC6740345.PMID12853434.
• Bonilha VL, Hollyfield JG, Grover S, Fishman GA (2005). "Abnormal distribution of red/green cone opsins in a patient with an autosomal dominant cone dystrophy".Ophthalmic Genet.26(2): 69–76.doi:10.1080/13816810590968041.PMID16020309.S2CID24486298.

External links

• GeneReviews/NIH/NCBI/UW entry on Red-Green Color Vision Defects