Jump to content

Overall hemostatic potential

Add links
From Wikipedia, the free encyclopedia

Overall hemostatic potential
SynonymsOverall hemostasis potential; Overall haemostasis potential; Overall haemostatic potential; OHP
Test ofCoagulation,hypercoagulability,hypocoagulability,hemostasis,fibrinolysis

Theoverall hemostatic potential(OHP) test is aglobal coagulation assaywhich can be used to measurecoagulation.[1][2][3][4]The OHP assay measures totalfibringeneration in the presence ofthrombinortissue factorandtissue plasminogen activator(t-PA).[2][1][3][4]It generates a fibrin time curve through the use ofoptical density measurement.[1]This curve represents the balance between fibrin formation induced by thrombin or tissue factor andfibrinolysisinduced by t-PA.[1]The assay provides three parameters:overall coagulation potential(OCP),overall hemostatic potential(OHP), andoverall fibrinolytic potential(OFP).[2][1][4]OHP is the main parameter, while OCP and OFP are supplementary parameters to assess coagulation and fibrinolysis.[3]One further parameter, clot lysis time (CLT), can also be determined.[3]The OHP assay measures the integrated effect ofprocoagulant,anticoagulant,and fibrinolytic factors.[1]

The OHP is a technically simple[1][3]but relatively labor-intensive assay.[2]As of 2010, it had been implemented in several laboratories, but was not available commercially.[3]The assay is novel in terms of its combined evaluation of both fibrin generation and fibrinolysis.[1]The test is potentially useful in the evaluation ofhypercoagulability,hypocoagulability,andfibrinolytic abnormalities.[1][2][3]It is able to detect hypercoagulability associated withpregnancyandestrogen/progestogenhormone therapy.[3][4]The test has also been used to study coagulation infeminizing hormone therapyintransgender women.[5]However, more studies are needed to validate the test as abiomarkerofthrombosisand other abnormalities of coagulation.[2][3][4]

History

[edit]

The original OHP assay was developed inSwedenby Blombäck and colleagues and was first described in 1999.[1][6][7]It used thrombin to trigger coagulation.[1]Since then, a modified version has been developed which can use either thrombin or tissue factor to trigger coagulation.[1][3][8][9]

References

[edit]
  1. ^abcdefghijklCurnow J (2017). "The Overall Hemostatic Potential (OHP) Assay".Hemostasis and Thrombosis.Methods Mol Biol. Vol. 1646. pp. 523–531.doi:10.1007/978-1-4939-7196-1_38.ISBN978-1-4939-7194-7.PMID28804852.
  2. ^abcdefLim HY, Donnan G, Nandurkar H, Ho P (January 2022). "Global coagulation assays in hypercoagulable states".J Thromb Thrombolysis.54(1): 132–144.doi:10.1007/s11239-021-02621-1.PMID34997471.S2CID245804095.
  3. ^abcdefghijAntovic A (October 2010). "The overall hemostasis potential: a laboratory tool for the investigation of global hemostasis".Semin Thromb Hemost.36(7): 772–9.doi:10.1055/s-0030-1265294.PMID20978998.S2CID35249276.
  4. ^abcdeAntovic A (July 2008). "Screening haemostasis--looking for global assays: the Overall Haemostasis Potential (OHP) method--a possible tool for laboratory investigation of global haemostasis in both hypo- and hypercoagulable conditions".Curr Vasc Pharmacol.6(3): 173–85.doi:10.2174/157016108784912028.PMID18673157.
  5. ^Lim HY, Leemaqz SY, Torkamani N, Grossmann M, Zajac JD, Nandurkar H, Ho P, Cheung AS (July 2020)."Global Coagulation Assays in Transgender Women on Oral and Transdermal Estradiol Therapy".J Clin Endocrinol Metab.105(7): e2369–e2377.doi:10.1210/clinem/dgaa262.PMID32413907.
  6. ^He S, Bremme K, Blombäck M (October 1999). "A laboratory method for determination of overall haemostatic potential in plasma. I. Method design and preliminary results".Thromb Res.96(2): 145–56.doi:10.1016/s0049-3848(99)00092-4.PMID10574592.
  7. ^He S, Antovic A, Blombäck M (September 2001). "A simple and rapid laboratory method for determination of haemostasis potential in plasma. II. Modifications for use in routine laboratories and research work".Thromb Res.103(5): 355–61.doi:10.1016/s0049-3848(01)00332-2.PMID11553368.
  8. ^Curnow JL, Morel-Kopp MC, Roddie C, Aboud M, Ward CM (March 2007). "Reduced fibrinolysis and increased fibrin generation can be detected in hypercoagulable patients using the overall hemostatic potential assay".J Thromb Haemost.5(3): 528–34.doi:10.1111/j.1538-7836.2007.02362.x.PMID17166248.S2CID25346726.
  9. ^Curnow, J. L. (2010). Evaluation of the overall haemostatic potential assay for the diagnosis and management of hypercoagulable states (Doctoral dissertation, University of Sydney).https://scholar.google.com/scholar?cluster=17586055299192023070
Retrieved from "https://en.wikipedia.org/w/index.php?title=Overall_hemostatic_potential&oldid=1196421966"