PCDH1

PCDH1
Identifiers
Aliases	PCDH1,PC42, PCDH42, protocadherin 1
External IDs	OMIM:603626;MGI:104692;HomoloGene:12613;GeneCards:PCDH1;OMA:PCDH1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	141,879,246bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	38,345,106bp
RNA expressionpattern
	Top expressed in
	mucosa of pharynx; ; beta cell; ; mucosa of transverse colon; ; right lung; ; minor salivary glands; ; skin of arm; ; apex of heart; ; upper lobe of left lung; ; skin of leg; ; olfactory zone of nasal mucosa;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; esophagus; ; lip; ; primary visual cortex; ; yolk sac; ; genital tubercle; ; tail of embryo; ; intestinal villus; ; epithelium of small intestine;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; cell-cell junction; nucleus; nucleolus; cell junction; intracellular membrane-bounded organelle;
Biological process	cell-cell signaling; cell adhesion; nervous system development; homophilic cell adhesion via plasma membrane adhesion molecules;
	Sources:Amigo/QuickGO
Orthologs
	5097
	75599
	ENSG00000156453
	ENSMUSG00000051375
	Q08174
	n/a
	NM_001278613; NM_001278615; NM_002587; NM_032420
	NM_029357
	NP_001265542; NP_001265544; NP_002578; NP_115796
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Protocadherin-1is aproteinthat in humans is encoded by thePCDH1gene.^[5]^[6]

This gene belongs to theprotocadherinsubfamily within thecadherinsuperfamily. The encoded protein is amembrane proteinfound at cell-cell boundaries. It is involved inneural celladhesion, suggesting a possible role in neuronal development. The protein includes an extracellular region, containing 7 cadherin-like domains, a transmembrane region and aC-terminalcytoplasmic region. Cells expressing the protein showed cell aggregation activity.Alternative splicingoccurs in this gene.^[6]

References

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000156453–Ensembl,May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000051375–Ensembl,May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Sano K, Tanihara H, Heimark RL, Obata S, Davidson M, St John T, Taketani S, Suzuki S (Jul 1993)."Protocadherins: a large family of cadherin-related molecules in central nervous system".EMBO J.12(6): 2249–56.doi:10.1002/j.1460-2075.1993.tb05878.x.PMC413453.PMID 8508762.
^^a ^b"Entrez Gene: PCDH1 protocadherin 1".

Yagi T, Takeichi M (2000)."Cadherin superfamily genes: functions, genomic organization, and neurologic diversity".Genes Dev.14(10): 1169–80.doi:10.1101/gad.14.10.1169.PMID 10817752.S2CID 44844497.
Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members".J. Mol. Biol.299(3): 551–72.doi:10.1006/jmbi.2000.3777.PMID 10835267.
Bonaldo MF, Lennon G, Soares MB (1997)."Normalization and subtraction: two approaches to facilitate gene discovery".Genome Res.6(9): 791–806.doi:10.1101/gr.6.9.791.PMID 8889548.
Del Mastro RG, Wang L, Simmons AD, et al. (1997)."Human chromosome-specific cDNA libraries: new tools for gene identification and genome annotation".Genome Res.5(2): 185–94.doi:10.1101/gr.5.2.185.PMID 9132272.
Wu Q, Maniatis T (2000)."Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes".Proc. Natl. Acad. Sci. U.S.A.97(7): 3124–9.doi:10.1073/pnas.060027397.PMC16203.PMID 10716726.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID 12477932.
Colland F, Jacq X, Trouplin V, et al. (2004)."Functional Proteomics Mapping of a Human Signaling Pathway".Genome Res.14(7): 1324–32.doi:10.1101/gr.2334104.PMC442148.PMID 15231748.
Ballif BA, Villén J, Beausoleil SA, et al. (2005)."Phosphoproteomic analysis of the developing mouse brain".Mol. Cell. Proteomics.3(11): 1093–101.doi:10.1074/mcp.M400085-MCP200.PMID 15345747.S2CID 18659460.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells".Nat. Biotechnol.23(1): 94–101.doi:10.1038/nbt1046.PMID 15592455.S2CID 7200157.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network".Nature.437(7062): 1173–8.Bibcode:2005Natur.437.1173R.doi:10.1038/nature04209.PMID 16189514.S2CID 4427026.
Otsuki T, Ota T, Nishikawa T, et al. (2007)."Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries".DNA Res.12(2): 117–26.doi:10.1093/dnares/12.2.117.PMID 16303743.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000156453–Ensembl,May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000051375–Ensembl,May 2017

[3] "Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8508762-5] Sano K, Tanihara H, Heimark RL, Obata S, Davidson M, St John T, Taketani S, Suzuki S (Jul 1993)."Protocadherins: a large family of cadherin-related molecules in central nervous system".EMBO J.12(6): 2249–56.doi:10.1002/j.1460-2075.1993.tb05878.x.PMC413453.PMID 8508762.

[entrez-6] "Entrez Gene: PCDH1 protocadherin 1".

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References

Further reading