PEST sequence
APEST sequenceis apeptide sequencethat is rich inproline(P),glutamic acid(E),serine(S) andthreonine(T). It is associated withproteinsthat have a short intracellularhalf-life,so might act as asignal peptideforprotein degradation.[1]This may be mediated via theproteasome[2][3]orcalpain.[4]
References
[edit]- ^Rogers S, Wells R, Rechsteiner M (1986). "Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis".Science.234(4774): 364–8.Bibcode:1986Sci...234..364R.doi:10.1126/science.2876518.PMID2876518.
- ^Reverte CG, Ahearn MD, Hake LE (2001)."CPEB degradation during Xenopus oocyte maturation requires a PEST domain and the 26S proteasome".Dev. Biol.231(2): 447–58.doi:10.1006/dbio.2001.0153.PMID11237472.
- ^Spencer ML, Theodosiou M, Noonan DJ (2004)."NPDC-1, a novel regulator of neuronal proliferation, is degraded by the ubiquitin/proteasome system through a PEST degradation motif".J. Biol. Chem.279(35): 37069–78.doi:10.1074/jbc.M402507200.PMID15229225.
- ^Shumway SD, Maki M, Miyamoto S (1999)."The PEST Domain of IκBα is necessary and sufficient for in vitro degradation by mu-calpain".J. Biol. Chem.274(43): 30874–81.doi:10.1074/jbc.274.43.30874.PMID10521480.
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