PFTK1

CDK14
Identifiers
Aliases	CDK14,PFTAIRE1, PFTK1, cyclin-dependent kinase 14, cyclin dependent kinase 14
External IDs	OMIM:610679;MGI:894318;HomoloGene:7888;GeneCards:CDK14;OMA:CDK14 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7q21.13 Start 90,466,424bp End 91,210,590bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 A1|5 2.61 cM Start 4,853,391bp End 5,470,312bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in postcentral gyrus Region I of hippocampus proper Pars compacta pars reticulata lateral nuclear group of thalamus entorhinal cortex Brodmann area 10 superior frontal gyrus Brodmann area 46 tendon of biceps brachii Top expressed in cingulate gyrus habenula medial dorsal nucleus amygdala mammillary body dentate gyrus lateral geniculate nucleus anterior amygdaloid area pontine nuclei medial geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity cyclin-dependent protein serine/threonine kinase activity kinase activity protein serine/threonine kinase activity protein binding ATP binding cyclin binding Cellular component membrane plasma membrane cytoplasmic cyclin-dependent protein kinase holoenzyme complex nucleus cytoplasm cytosol Biological process phosphorylation regulation of canonical Wnt signaling pathway Wnt signaling pathway cell division protein phosphorylation G2/M transition of mitotic cell cycle cell cycle regulation of cell cycle Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 5218 18647 Ensembl ENSG00000058091 ENSMUSG00000028926 UniProt O94921 O35495 RefSeq (mRNA) NM_001287135 NM_001287136 NM_001287137 NM_012395 NM_011074 NM_001310448 RefSeq (protein) NP_001274064 NP_001274065 NP_001274066 NP_036527 NP_001297377 NP_035204 Location (UCSC) Chr 7: 90.47 – 91.21 Mb Chr 5: 4.85 – 5.47 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase PFTAIRE-1is anenzymethat in humans is encoded by theCDK14gene.

Interactions

PFTK1 has been shown tointeractwithSEPT8.

Further reading

• Nagase T, Ishikawa K, Suyama M, et al. (1999)."Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro".DNA Res.5(6): 355–64.doi:10.1093/dnares/5.6.355.PMID10048485.
• Yang T, Gao YK, Chen JY (2002). "KIAA0202, a human septin family member, interacting with hPFTAIRE1".Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao.34(4): 520–5.PMID12098780.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003)."Human chromosome 7: DNA sequence and biology".Science.300(5620): 767–72.Bibcode:2003Sci...300..767S.doi:10.1126/science.1083423.PMC2882961.PMID12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003)."The DNA sequence of human chromosome 7".Nature.424(6945): 157–64.Bibcode:2003Natur.424..157H.doi:10.1038/nature01782.PMID12853948.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells".Science.307(5715): 1621–5.Bibcode:2005Sci...307.1621B.doi:10.1126/science.1105776.PMID15761153.S2CID39457788.
• Gao Y, Jiang M, Yang T, et al. (2006)."A Cdc2-related protein kinase hPFTAIRE1 from human brain interacting with 14-3-3 proteins".Cell Res.16(6): 539–47.doi:10.1038/sj.cr.7310071.PMID16775625.
• Ewing RM, Chu P, Elisma F, et al. (2007)."Large-scale mapping of human protein-protein interactions by mass spectrometry".Mol. Syst. Biol.3(1): 89.doi:10.1038/msb4100134.PMC1847948.PMID17353931.
• Shu F, Lv S, Qin Y, et al. (2007)."Functional characterization of human PFTK1 as a cyclin-dependent kinase".Proc. Natl. Acad. Sci. U.S.A.104(22): 9248–53.Bibcode:2007PNAS..104.9248S.doi:10.1073/pnas.0703327104.PMC1890480.PMID17517622.
• Denoeud F, Kapranov P, Ucla C, et al. (2007)."Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions".Genome Res.17(6): 746–59.doi:10.1101/gr.5660607.PMC1891335.PMID17567994.