PKNOX1
Appearance
PBX/Knotted 1 Homeobox 1(PKNOX1) is aproteinthat in humans is encoded by thePKNOX1gene.[5][6]
An importantparalogof this gene isPKNOX2.
Function[edit]
PKNOX1 belongs to the threeamino acidloop extension(TALE) class ofhomeodomaintranscription factorsthat formtranscriptionally activecomplexes involved in development andorganogenesis.PKNOX1 is essential forembryogenesis,but it can also act as atumor suppressorinadulthood.[7]
References[edit]
- ^abcGRCh38: Ensembl release 89: ENSG00000160199–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000006705–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Berthelsen J, Viggiano L, Schulz H, Ferretti E, Consalez GG, Rocchi M, Blasi F (January 1998). "PKNOX1, a gene encoding PREP1, a new regulator of Pbx activity, maps on human chromosome 21q22.3 and murine chromosome 17B/C".Genomics.47(2): 323–4.doi:10.1006/geno.1997.5086.PMID9479508.
- ^"Entrez Gene: PKNOX1 PBX/knotted 1 homeobox 1".Archivedfrom the original on 2010-12-05.Retrieved2017-09-07.
- ^Purushothaman D, Blasi F (2018)."The genetics and the molecular functions of the PREP1 homeodomain transcription factor".The International Journal of Developmental Biology.62(11–12): 819–825.doi:10.1387/ijdb.180238fb.PMID30604851.
Further reading[edit]
- Allen TD, Zhu YX, Hawley TS, Hawley RG (October 2000). "TALE homeoproteins as HOX11-interacting partners in T-cell leukemia".Leukemia & Lymphoma.39(3–4): 241–56.doi:10.3109/10428190009065824.PMID11342305.S2CID27407074.
- Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML (March 1995)."Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins".Genes & Development.9(6): 663–74.doi:10.1101/gad.9.6.663.PMID7729685.
- Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".Gene.138(1–2): 171–4.doi:10.1016/0378-1119(94)90802-8.PMID8125298.
- Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, et al. (September 1996)."Generation and analysis of 280,000 human expressed sequence tags".Genome Research.6(9): 807–28.doi:10.1101/gr.6.9.807.PMID8889549.
- Phelan ML, Featherstone MS (March 1997)."Distinct HOX N-terminal arm residues are responsible for specificity of DNA recognition by HOX monomers and HOX.PBX heterodimers".The Journal of Biological Chemistry.272(13): 8635–43.doi:10.1074/jbc.272.13.8635.PMID9079695.
- Chen H, Rossier C, Nakamura Y, Lynn A, Chakravarti A, Antonarakis SE (April 1997). "Cloning of a novel homeobox-containing gene, PKNOX1, and mapping to human chromosome 21q22.3".Genomics.41(2): 193–200.doi:10.1006/geno.1997.4632.PMID9143494.
- LeBrun DP, Matthews BP, Feldman BJ, Cleary ML (October 1997)."The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains".Oncogene.15(17): 2059–67.doi:10.1038/sj.onc.1201367.PMID9366523.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".Gene.200(1–2): 149–56.doi:10.1016/S0378-1119(97)00411-3.PMID9373149.
- Berthelsen J, Zappavigna V, Mavilio F, Blasi F (March 1998)."Prep1, a novel functional partner of Pbx proteins".The EMBO Journal.17(5): 1423–33.doi:10.1093/emboj/17.5.1423.PMC1170490.PMID9482739.
- Berthelsen J, Zappavigna V, Ferretti E, Mavilio F, Blasi F (March 1998)."The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity".The EMBO Journal.17(5): 1434–45.doi:10.1093/emboj/17.5.1434.PMC1170491.PMID9482740.
- Green NC, Rambaldi I, Teakles J, Featherstone MS (May 1998)."A conserved C-terminal domain in PBX increases DNA binding by the PBX homeodomain and is not a primary site of contact for the YPWM motif of HOXA1".The Journal of Biological Chemistry.273(21): 13273–9.doi:10.1074/jbc.273.21.13273.PMID9582372.
- Berthelsen J, Kilstrup-Nielsen C, Blasi F, Mavilio F, Zappavigna V (April 1999)."The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH".Genes & Development.13(8): 946–53.doi:10.1101/gad.13.8.946.PMC316640.PMID10215622.
- Jacobs Y, Schnabel CA, Cleary ML (July 1999)."Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity".Molecular and Cellular Biology.19(7): 5134–42.doi:10.1128/mcb.19.7.5134.PMC84356.PMID10373562.
- Knoepfler PS, Bergstrom DA, Uetsuki T, Dac-Korytko I, Sun YH, Wright WE, et al. (September 1999)."A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1".Nucleic Acids Research.27(18): 3752–61.doi:10.1093/nar/27.18.3752.PMC148632.PMID10471746.
- Kömüves LG, Shen WF, Kwong A, Stelnicki E, Rozenfeld S, Oda Y, et al. (August 2000)."Changes in HOXB6 homeodomain protein structure and localization during human epidermal development and differentiation".Developmental Dynamics.218(4): 636–47.doi:10.1002/1097-0177(2000)9999:9999<::AID-DVDY1014>3.0.CO;2-I.PMID10906782.
- Okada Y, Matsuura E, Nagai R, Sato T, Watanabe A, Morita I, Doi T (May 2003). "PREP1, MEIS1 homolog protein, regulates PF4 gene expression".Biochemical and Biophysical Research Communications.305(1): 155–9.doi:10.1016/S0006-291X(03)00718-6.PMID12732210.
External links[edit]
- PKNOX1+protein,+humanat the U.S. National Library of MedicineMedical Subject Headings(MeSH)
This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.