Phenylbiguanide

Phenylbiguanide
Legal status
Legal status	UN:Unscheduled;
Identifiers
	IUPAC name 1-Phenylbiguanide;
CAS Number	102-02-3;
PubChemCID	4780;
ChemSpider	4616;
UNII	W8PKA3T2I3;
ChEBI	CHEBI:75377;
ChEMBL	ChEMBL13791;
CompTox Dashboard(EPA)	DTXSID90144508;
ECHA InfoCard	100.002.726
Chemical and physical data
Formula	C8H11N5
Molar mass	177.211g·mol−1
3D model (JSmol)	Interactive image;
Melting point	135–142 °C (275–288 °F)
	SMILES c1ccc(cc1)NC(=N)NC(=N)N;
	InChI InChI=1S/C8H11N5/c9-7(10)13-8(11)12-6-4-2-1-3-5-6/h1-5H,(H6,9,10,11,12,13); Key:CUQCMXFWIMOWRP-UHFFFAOYSA-N;

Phenylbiguanide(PBG) is a5-HT3 agonistused to study the role of 5-HT3 receptors in thecentral nervous system.^[1]It has been found to triggerdopaminerelease in thenucleus accumbensof rats.^[2]

Derivatives[edit]

^Higgins GA, Joharchi N, Sellers EM (March 1993). "Behavioral effects of the 5-hydroxytryptamine3 receptor agonists 1-phenylbiguanide and m-chlorophenylbiguanide in rats".The Journal of Pharmacology and Experimental Therapeutics.264(3). Journal of Pharmacology and Experimental Therapeutics: 1440–9.PMID 8450478.
^Chen JP, van Praag HM, Gardner EL (March 1991). "Activation of 5-HT3 receptor by 1-phenylbiguanide increases dopamine release in the rat nucleus accumbens".Brain Research.543(2). Brain Research.: 354–7.doi:10.1016/0006-8993(91)90050-6.PMID 1711914.S2CID 37426395.

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