Menopause
Menopause | |
---|---|
Other names | Climacteric |
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Specialty | Gynecology |
Symptoms | Nomenstrual periodsfor a year[1] |
Duration | ~3 years |
Causes | Usually a natural change. Can also be caused by surgery that removes bothovaries,and some types ofchemotherapy.[2][3] |
Treatment | None, lifestyle changes[4] |
Medication | Menopausal hormone therapy,clonidine,gabapentin,selective serotonin reuptake inhibitors[4][5] |
Menopause,also known as theclimacteric,is the time whenmenstrual periodspermanently stop, marking the end of reproduction.[1][6]It typically occurs between the ages of 45 and 55, although the exact timing can vary.[7]Menopause is usually a natural change.[3]It can occur earlier in those whosmoke tobacco.[2][8]Other causes include surgery that removes bothovariesor some types ofchemotherapy.[9][2]At the physiological level, menopause happens because of a decrease in the ovaries' production of the hormonesestrogenandprogesterone.[1]While typically not needed, a diagnosis of menopause can be confirmed by measuring hormone levels in the blood or urine.[10]Menopause is the opposite ofmenarche,the time when a girl's periods start.[11]
In the years before menopause, a woman's periods typically become irregular,[12][13]which means that periods may be longer or shorter in duration or be lighter or heavier in the amount of flow.[12]During this time, women often experiencehot flashes;these typically last from 30 seconds to ten minutes and may be associated with shivering,night sweats,and reddening of the skin.[12]Hot flashes[12]can recur for four to five years.[6]Other symptoms may includevaginal dryness,trouble sleeping, and mood changes.[12]The severity of symptoms varies between women.[6] Menopause before the age of 45 years is considered to be "early menopause" and when ovarian failure/surgical removal of the ovaries occurs before the age of 40 years this is termed "premature ovarian insufficiency".[14]
In addition to symptoms (hot flushes/flashes, night sweats, mood changes,arthralgiaand vaginal dryness), the physical consequences of menopause include bone loss, increased central abdominal fat, and adverse changes in a woman's cholesterol profile and vascular function.[14]These changes predispose postmenopausal women to increased risks ofosteoporosisand bone fracture, and of cardio-metabolic disease (diabetes and cardiovascular disease).[14]
Medical professionalsoften define menopause as having occurred when a woman has not had any menstrual bleeding for a year.[2]It may also be defined by a decrease inhormoneproduction by theovaries.[15]In those who have hadsurgeryto remove theiruterusbut still have functioning ovaries, menopause is not considered to have yet occurred.[14]Following the removal of the uterus, symptoms of menopause typically occur earlier.[16]Iatrogenic menopause occurs when both ovaries are surgically removed along with uterus for medical reasons.
The primary indications for treatment of menopause are symptoms and prevention of bone loss.[17]Mild symptoms may be improved with treatment. With respect to hot flashes, avoiding smoking, caffeine, and alcohol is often recommended; sleeping naked in a cool room and using a fan may help. The most effective treatment for menopausal symptoms ismenopausal hormone therapy(MHT).[17]Non-hormonal therapies for hot flashes includecognitive-behavioral therapy,clinical hypnosis,gabapentin,fezolinetantorselective serotonin reuptake inhibitors.[18][19]These will not improve symptoms such as joint pain or vaginal dryness which affect over 55% of women.[17]Exercise may help with sleeping problems. Many of the concerns about the use of MHT raised by older studies are no longer considered barriers to MHT in healthy women.[17]High-quality evidence for the effectiveness ofalternative medicinehas not been found.[6]
Signs and symptoms
[edit]![](https://upload.wikimedia.org/wikipedia/commons/thumb/9/9f/Symptoms_of_menopause_%28vector%29.svg/300px-Symptoms_of_menopause_%28vector%29.svg.png)
During early menopause transition, themenstrual cyclesremain regular but the interval between cycles begins to lengthen. Hormone levels begin to fluctuate. Ovulation may not occur with each cycle.[20]
The termmenopauserefers to a point in time that follows one year after the lastmenstruation.[20]During the menopausal transition and after menopause, women can experience a wide range of symptoms.[12]However, for women who enter the menopause transition without having regular menstrual cycles (due to prior surgery, other medical conditions or ongoing hormonal contraception) the menopause cannot be identified by bleeding patterns and is defined as the permanent loss of ovarian function.[17]
Vagina, uterus and bladder (urogenital tract)
[edit]![](https://upload.wikimedia.org/wikipedia/commons/thumb/7/77/Vaginal_Canal_Normal_vs._Menopause.png/220px-Vaginal_Canal_Normal_vs._Menopause.png)
During the transition to menopause,menstrual patternscan show shorter cycling (by 2–7 days);[20]longer cycles remain possible.[20]There may beirregular bleeding[12](lighter, heavier, spotting).[20]Dysfunctional uterine bleedingis often experienced by women approaching menopause due to the hormonal changes that accompany the menopause transition. Spotting or bleeding may simply be related to vaginalatrophy,a benign sore (polypor lesion), or may be a functional endometrial response. TheEuropean Menopause and Andropause Societyhas released guidelines for assessment of theendometrium,which is usually the main source of spotting or bleeding.[21]
In post-menopausal women, however, any unscheduled vaginalbleedingis of concern and requires an appropriate investigation to rule out the possibility of malignant diseases.
Urogenital symptoms (that may appear during menopause and continue throughpostmenopause) includepainful intercourse,vaginal drynessandatrophic vaginitis– thinning of the membranes of thevulva,thevagina,thecervixand the outerurinary tract,along with considerable shrinking and loss in elasticity of all of the outer and inner genital areas –urinary urgencyand burning up tourinary incontinence.[20]
Other physical effects
[edit]![](https://upload.wikimedia.org/wikipedia/commons/thumb/7/74/Menopause_-_Osteoporosis_--_Smart-Servier_%28cropped%29.jpg/220px-Menopause_-_Osteoporosis_--_Smart-Servier_%28cropped%29.jpg)
The most common physical symptoms of menopause are heavynight sweats,andhot flashes(also known as vasomotor symptoms).[22]Sleeping problems andinsomniaare also common.[23]Other physical symptoms may be reported that are not specific to menopause but may be exacerbated by it, such aslack of energy,joint soreness,stiffness,back pain,breast enlargement,breast pain,heart palpitations,headache,dizziness,dry,itchyskin, thinning,tinglingskin,rosacea,weight gain.[20][24]
Mood and memory effects
[edit]Psychological symptoms are often reported but they are not specific to menopause and can be caused by other factors.[25][26]They includeanxiety,poor memory, inability to concentrate, depressive mood,irritability,mood swings,and lessinterest in sexual activity.[20][27][12]
Menopause-related cognitive impairmentcan be confused with themild cognitive impairmentthat precedesdementia.[28]There is evidence of small decreases in verbal memory, on average, which may be caused by the effects of declining estrogen levels on the brain,[29]or perhaps by reduced blood flow to the brain duringhot flashes.[30]However, these tend to resolve for most women during the postmenopause. Subjective reports of memory and concentration problems are associated with several factors, such as lack of sleep, and stress.[26][25]
Long-term effects
[edit]Cardiovascular health
[edit]Exposure to endogenousestrogenduring reproductive years provides women with protection againstcardiovascular disease,which is lost around 10 years after the onset of menopause. The menopausal transition is associated with an increase infat mass(predominantly invisceral fat), an increase ininsulin resistance,dyslipidaemia,andendothelial dysfunction.[31]Women withvasomotor symptomsduring menopause seem to have an especially unfavorable cardiometabolic profile,[32]as well as women with premature onset of menopause (before 45 years of age).[33]These risks can be reduced by managing risk factors, such as tobacco smoking,hypertension,increasedblood lipidsand body weight.[34][35]
Bone health
[edit]The annual rates ofbone mineral densityloss are highest starting one year before the final menstrual period and continuing through the two years after it.[36]Thus, post menopausal women are at increased risk ofosteopenia,osteoporosisandfractures.
Causes
[edit]Menopause can be induced or occur naturally. Induced menopause[37]occurs as a result of medical treatment such aschemotherapy,radiotherapy,oophorectomy,or complications oftubal ligation,hysterectomy,unilateral or bilateral salpingo-oophorectomy orleuprorelinusage.[38]
Age
[edit]Menopause typically occurs at some point between 47 and 54 years of age.[7]According to various data, more than 95% of women have their last period between the ages of 44–56 (median 49–50). 2% of women under the age of 40, 5% between the ages of 40–45 and the same number between the ages of 55–58 have their last bleeding.[39]The average age of the last period in the United States is 51 years, in Russia is 50 years, in Greece is 49 years, in Turkey is 47 years, in Egypt is 47 years and in India is 46 years.[40]The menopausal transition or perimenopause leading up to menopause usually lasts 3–4 years (sometimes as long as 5–14 years).[1][13]
Undiagnosed and untreatedcoeliac diseaseis a risk factor for early menopause. Coeliac disease can present with several non-gastrointestinal symptoms, in the absence of gastrointestinal symptoms, and most cases escape timely recognition and go undiagnosed, leading to a risk of long-term complications. A strictgluten-free dietreduces the risk. Women with early diagnosis and treatment of coeliac disease present a normal duration of fertile life span.[41][42]
Women who have undergonehysterectomywith ovary conservation go through menopause on average 1.5 years earlier than the expected age.[17]
Premature ovarian insufficiency
[edit]In rare cases, a woman's ovaries stop working at a very early age, ranging anywhere from the age ofpubertyto age 40. This is known aspremature ovarian failureand affects 1 to 2% of women by age 40.[43]also called premature ovarian insufficiency (POI)[44][45]It is diagnosed or confirmed by high blood levels offollicle stimulating hormone(FSH) andluteinizing hormone(LH) on at least three occasions at least four weeks apart.[46]
Premature ovarian insufficiency may be auto immune and therefore might co occur with otherautoimmune disorderssuch asthyroiddisease, [adrenal insufficiency], anddiabetes mellitus.Other causes includechemotherapy,being a carrier of thefragile X syndromegene, andradiotherapy.[45]However, in about 50–80% of cases of premature ovarian insufficiency, the cause is unknown, i.e., it is generallyidiopathic.[44][46]
An early menopause can be related tocigarettesmoking, higherbody mass index,racial and ethnic factors, illnesses, and the removal of the uterus.[47]
Rates of premature menopause have been found to be significantly higher in fraternal and identicaltwins;about 5% of twins reach menopause before the age of 40.[dubious–discuss]The reasons for this are not completely understood.[48]
Surgical menopause
[edit]Menopause can be surgically induced by bilateraloophorectomy(removal of ovaries),[37]which is often, but not always, done in conjunction with removal of the fallopian tubes (salpingo-oophorectomy) and uterus (hysterectomy).[49]Cessation of menses as a result of removal of the ovaries is called "surgical menopause". Surgical treatments, such as the removal of ovaries, might cause periods to stop altogether.[50]The sudden and complete drop in hormone levels may produce extreme withdrawal symptoms such as hot flashes, etc. The symptoms of early menopause may be more severe.[50]
Removal of the uteruswithoutremoval of the ovaries doesnotdirectly cause menopause, although pelvic surgery of this type can often precipitate a somewhat earlier menopause, perhaps because of a compromised blood supply to the ovaries.[medical citation needed]The time between surgery and possible early menopause is due to the fact that ovaries are still producing hormones.[50]
Mechanism
[edit]![](https://upload.wikimedia.org/wikipedia/commons/thumb/9/91/615_Age_and_Bone_Mass.jpg/220px-615_Age_and_Bone_Mass.jpg)
The menopausal transition, and postmenopause itself, is a natural change, not usually a disease state or a disorder. The main cause of this transition is the natural depletion and aging of the finite amount ofoocytes(ovarian reserve). This process is sometimes accelerated by other conditions and is known to occur earlier after a wide range of gynecologic procedures such ashysterectomy(with and withoutovariectomy),endometrial ablationanduterine artery embolisation.The depletion of the ovarian reserve causes an increase in circulatingfollicle-stimulating hormone(FSH) andluteinizing hormone(LH) levels because there are feweroocytesand follicles responding to these hormones and producing estrogen.
The transition has a variable degree of effects.[51]
The stages of the menopause transition have been classified according to a woman's reported bleeding pattern, supported by changes in the pituitaryfollicle-stimulating hormone(FSH) levels.[52]
In younger women, during a normalmenstrual cyclethe ovaries produceestradiol,testosteroneandprogesteronein a cyclical pattern under the control of FSH andluteinizing hormone(LH), which are both produced by thepituitary gland.During perimenopause (approaching menopause),estradiollevels and patterns of production remain relatively unchanged or may increase compared to young women, but the cycles become frequently shorter or irregular.[53]The often observed increase in estrogen is presumed to be in response to elevated FSH levels that, in turn, is hypothesized to be caused by decreased feedback byinhibin.[54]Similarly, decreased inhibin feedback afterhysterectomyis hypothesized to contribute to increased ovarian stimulation and earlier menopause.[55][56]
The menopausal transition is characterized by marked, and often dramatic, variations in FSH and estradiol levels. Because of this, measurements of these hormones arenotconsidered to be reliable guides to a woman's exact menopausal status.[54]
Menopause occurs because of the sharp decrease of estradiol and progesterone production by the ovaries. After menopause, estrogen continues to be produced mostly byaromatasein fat tissues and is produced in small amounts in many other tissues such as ovaries, bone, blood vessels, and the brain where it acts locally.[57]The substantial fall in circulating estradiol levels at menopause impacts many tissues, from brain to skin.
In contrast to the sudden fall in estradiol during menopause, the levels of total and free testosterone, as well asdehydroepiandrosterone sulfate(DHEAS) andandrostenedioneappear to decline more or less steadily with age. An effect of natural menopause on circulatingandrogenlevels has not been observed.[58]Thus specific tissue effects of natural menopause cannot be attributed to loss of androgenic hormone production.[59]
Hot flashes and other vasomotor and body symptoms accompanying the menopausal transition are associated with estrogen insufficiency and changes that occur in the brain, primarily thehypothalamusand involve complex interplay between the neurotransmitterskisspeptin,neurokinin B,anddynorphin,which are found in KNDy neurons in the infundibular nucleus.[60]
Ovarian aging
[edit]Decreased inhibin feedback afterhysterectomyis hypothesized to contribute to increased ovarian stimulation and earlier menopause. Hastened ovarian aging has been observed afterendometrial ablation.While it is difficult to prove that these surgeries are causative, it has been hypothesized that theendometriummay be producing endocrine factors contributing to the endocrine feedback and regulation of the ovarian stimulation. Elimination of these factors contributes to faster depletion of the ovarian reserve. Reduced blood supply to the ovaries that may occur as a consequence of hysterectomy anduterine artery embolisationhas been hypothesized to contribute to this effect.[55][56]
ImpairedDNArepair mechanisms may contribute to earlier depletion of the ovarian reserve during aging.[61]As women age, double-strand breaks accumulate in the DNA of their primordial follicles. Primordial follicles are immature primary oocytes surrounded by a single layer of granulosa cells. An enzyme system is present in oocytes that ordinarily accurately repairs DNA double-strand breaks. This repair system is called "homologous recombinationalrepair ", and it is especially effective during meiosis. Meiosis is the general process by which germ cells are formed in all sexual eukaryotes; it appears to be an adaptation for efficiently removing damages in germ line DNA.[62]
Human primary oocytes are present at an intermediate stage of meiosis, termed prophase I (seeOogenesis). Expression of four key DNA repair genes that are necessary for homologous recombinational repair during meiosis (BRCA1, MRE11, Rad51, and ATM) decline with age in oocytes.[61]This age-related decline in ability to repair DNA double-strand damages can account for the accumulation of these damages, that then likely contributes to the depletion of the ovarian reserve.
Diagnosis
[edit]Ways of assessing the impact on women of some of these menopause effects, include theGreene climacteric scalequestionnaire,[63]the Cervantes scale[64]and the Menopause rating scale.[65]
Perimenopause
[edit]The term "perimenopause", which literally means "around the menopause", refers to the menopause transition years before the date of the final episode of flow.[1][13][66][67]According to theNorth American Menopause Society,this transition can last for four to eight years.[68]TheCentre for Menstrual Cycle and Ovulation Researchdescribes it as a six- to ten-year phase ending 12 months after the last menstrual period.[69]
During perimenopause,estrogenlevels average about 20–30% higher than during premenopause, often with wide fluctuations.[69]These fluctuations cause many of the physical changes during perimenopause as well as menopause, especially during the last 1–2 years of perimenopause (before menopause).[66][70]Some of these changes arehot flashes,night sweats, difficulty sleeping, mood swings,vaginal drynessoratrophy,incontinence,osteoporosis,and heart disease.[69]Perimenopause is also associated with a higher likelihood of depression (affecting from 45 percent to 68 percent of perimenopausal women), which is twice as likely to affect those with a history of depression.[71]
During this period,fertilitydiminishes but is not considered to reach zero until the official date of menopause. The official date is determined retroactively, once 12 months have passed after the last appearance of menstrual blood.
The menopause transition typically begins between 40 and 50 years of age (average 47.5).[72][73]The duration of perimenopause may be for up to eight years.[73]Women will often, but not always, start these transitions (perimenopause and menopause) about the same time as their mother did.[74]
Some research appears to show thatmelatoninsupplementation in perimenopausal women can improve thyroid function and gonadotropin levels, as well as restoring fertility and menstruation and preventing depression associated with menopause.[75]
Postmenopause
[edit]The term "postmenopausal" describes women who have not experienced any menstrual flow for a minimum of 12 months, assuming that they have auterusand are not pregnant orlactating.[49]The reason for this delay in declaring postmenopause is that periods are usually erratic during menopause. Therefore, a reasonably long stretch of time is necessary to be sure that the cycling has ceased. At this point a woman is considered infertile; however, the possibility of becoming pregnant has usually been very low (but not quite zero) for a number of years before this point is reached.[citation needed]
In women with or without a uterus, menopause or postmenopause can also be identified by a blood test showing a very highfollicle-stimulating hormonelevel, greater than 25 IU/L in a random blood draw; it rises as ovaries become inactive.[49]FSH continues to rise, as its counterpart estradiol continues to drop for about 2 years after the last menstrual period, after which the levels of each of these hormones stabilize. The stabilization period after the begin of early postmenopause has been estimated to last 3 to 6 years, so early postmenopause lasts altogether about 5 to 8 years, during which hormone withdrawal effects such as hot flashes disappear.[49]Finally, late postmenopause has been defined as the remainder of a woman s lifespan, when reproductive hormones do not change any more.[citation needed]
A period-like flow during postmenopause, even spotting, may be a sign ofendometrial cancer.
Management
[edit]Perimenopause is a natural stage of life. It is not a disease or a disorder. Therefore, it does not automatically require any kind of medical treatment. However, in those cases where the physical, mental, and emotional effects of perimenopause are strong enough that they significantly disrupt the life of the woman experiencing them, palliative medical therapy may sometimes be appropriate.
Menopausal hormone therapy
[edit]In the context of the menopause,menopausal hormone therapy(MHT) is the use ofestrogenin women without a uterus and estrogen plusprogestogenin women who have an intact uterus.[76]
MHT may be reasonable for the treatment of menopausal symptoms, such as hot flashes.[77]It is the most effective treatment option, especially when delivered as a skin patch.[78][79]Its use, however, appears to increase the risk ofstrokesandblood clots.[80]When used for menopausal symptoms the global recommendation is MHT should be prescribed for a long as there are defined treatment effects and goals for the individual woman.[17]
MHT is also effective for preventing bone loss andosteoporoticfracture,[81]but it is generally recommended only for women at significant risk for whom other therapies are unsuitable.[82]
MHT may be unsuitable for some women, including those at increased risk of cardiovascular disease, increased risk of thromboembolic disease (such as those with obesity or a history of venous thrombosis) or increased risk of some types of cancer.[82]There is some concern that this treatment increases the risk of breast cancer.[83]Women at increased risk of cardiometabolic disease and VTE may be able to use transdermal estradiol which does not appear to increase risks in low to moderate doses.[17]
Addingtestosteroneto hormone therapy has a positive effect on sexual function in postmenopausal women, although it may be accompanied by hair growth or acne if used in excess. Transdermal testosterone therapy in appropriate dosing is generally safe.[84]
Selective estrogen receptor modulators
[edit]SERMsare a category of drugs, either synthetically produced or derived from a botanical source, that act selectively as agonists or antagonists on theestrogen receptorsthroughout the body. The most commonly prescribed SERMs areraloxifeneandtamoxifen.Raloxifene exhibits oestrogen agonist activity on bone and lipids, and antagonist activity on breast and the endometrium.[85]Tamoxifen is in widespread use for treatment of hormone sensitive breast cancer. Raloxifene prevents vertebral fractures in postmenopausal, osteoporotic women and reduces the risk of invasive breast cancer.[86]
Other medications
[edit]Some of theSSRIsandSNRIsappear to provide some relief from vasomotor symptoms.[19][18]The most effective SSRIs and SNRIs areparoxetine,escitalopram,citalopram,venlafaxine,anddesvenlafaxine.[18]They may, however, be associated with appetite and sleeping problems, constipation and nausea.[19][87]
Gabapentinorfezolinetantcan also improve the frequency and severity of vasomotor symptoms.[19][18]Side effects of using gabapentin include drowsiness and headaches.[19][87]
Therapy
[edit]Cognitive behavioural therapyandclinical hypnosiscan decrease the amount women are affected by hot flashes.[18]Mindfulnessis not yet proven to be effective in easing vasomotor symptoms.[88][89][18]
Lifestyle and exercise
[edit]Exercise has been thought to reduce postmenopausal symptoms through the increase of endorphin levels, which decrease as estrogen production decreases.[90]However, there is insufficient evidence to suggest that exercise helps with the symptoms of menopause.[18]Similarly, yoga has not been shown to be useful as a treatment for vasomotor symptoms.[18]
However a highBMIis a risk factor for vasomotor symptoms in particular. Weight loss may help with symptom management.[91][18]
There is no strong evidence that cooling techniques such as using specific clothing or environment control tools (for example fans) help with symptoms.[18]Paced breathing andrelaxationare not effective in easing symptoms.[18]
Dietary supplements
[edit]There is no evidence of consistent benefit of taking anydietary supplementsorherbal productsfor menopausal symptoms.[18][92][93]These widely marketed but ineffective supplements includesoy isoflavones,pollen extracts,black cohosh,omega-3among many others.[18][94][95]
Alternative medicine
[edit]There is no evidence of consistent benefit ofalternative therapiesfor menopausal symptoms despite their popularity.[93][18]
As of 2023, there is no evidence to support the efficacy ofacupunctureas a management for menopausal symptoms.[18][96][93]TheCochrane reviewfound not enough evidence in 2016 to show a difference between Chinese herbal medicine and placebo for thevasomotorsymptoms.[97]
Other efforts
[edit]- Lack of lubrication is a common problem during and after perimenopause. Vaginal moisturizers can help women with overall dryness, and lubricants can help with lubrication difficulties that may be present during intercourse. It is worth pointing out that moisturizers and lubricants are different products for different issues: some women complain that their genitalia are uncomfortably dry all the time, and they may do better with moisturizers. Those who need only lubricants do well using them only during intercourse.
- Low-dose prescription vaginal estrogen products such as estrogen creams are generally a safe way to use estrogen topically, to help vaginal thinning and dryness problems (seevaginal atrophy) while only minimally increasing the levels of estrogen in the bloodstream.
- Individual counseling or support groups can sometimes be helpful to handle sad, depressed, anxious or confused feelings women may be having as they pass through what can be for some a very challenging transition time.
- Osteoporosiscan be minimized bysmoking cessation,adequatevitamin Dintake and regular weight-bearing exercise. The bisphosphonate drug alendronate may decrease the risk of a fracture, in women that have both bone loss and a previous fracture and less so for those with just osteoporosis.[98]
- A surgical procedure where a part of one of the ovaries is removed earlier in life and frozen and then over time thawed and returned to the body (ovarian tissue cryopreservation) has been tried. While at least 11 women have undergone the procedure and paid over £6,000, there is no evidence it is safe or effective.[99]
Society and culture
[edit]Attitudes and experiences
[edit]The menopause transition is a process, involving hormonal, menstrual, and typically vasomotor changes. However, the experience of the menopause as a whole is very much influenced by psychological and social factors, such as past experience, lifestyle, social and cultural meanings of menopause, and a woman's social and material circumstances. Menopause has been described as abiopsychosocialexperience, with social and cultural factors playing a prominent role in the way menopause is experienced and perceived.[citation needed]
The paradigm within which a woman considers menopause influences the way she views it: women who understand menopause as a medical condition rate it significantly more negatively than those who view it as a life transition or a symbol of aging.[100]There is some evidence that negative attitudes and expectations, held before the menopause, predict symptom experience during the menopause,[101]and, interestingly, beliefs and attitudes toward menopause tend to be more positive in postmenopausal than in premenopausal women.[102]Women with more negative attitudes towards the menopause report more symptoms during this transition.[101]
Menopause is a stage of life experienced in different ways. It can be characterized by personal challenges, changes in personal roles within the family and society. Women's approaches to changes during menopause are influenced by their personal, family and sociocultural background.[103]Women from different regions and countries also have different attitudes. Postmenopausal women had more positive attitudes toward menopause compared with peri- or premenopausal women. Other influencing factors of attitudes toward menopause include age, menopausal symptoms, psychological and socioeconomical status, and profession and ethnicity.[104]
Ethnicity and geography play roles in the experience of menopause. American women of different ethnicities report significantly different types of menopausal effects. One major study found Caucasian women most likely to report what are sometimes described as psychosomatic symptoms, while African-American women were more likely to report vasomotor symptoms.[105]
There may be variations in experiences of women from different ethnic backgrounds regarding menopause and care. Immigrant women reported more vasomotor symptoms and other physical symptoms and poorer mental health than non-immigrant women and were mostly dissatisfied with the care they had received. Self-management strategies for menopausal symptoms were also influenced by culture.[106]
Two multinational studies of Asian women, found that hot flushes were not the most commonly reported symptoms, instead body and joint aches, memory problems, sleeplessness, irritability and migraines were.[107]In another study comparing experiences of menopause amongst White Australian women and women in Laos, Australian women reported higher rates of depression, as well as fears of aging, weight gain and cancer – fears not reported by Laotian women, who positioned menopause as a positive event.[108]Japanese women experience menopause effects, orkonenki,in a different way from American women.[109]Japanese women report lower rates of hot flashes and night sweats; this can be attributed to a variety of factors, both biological and social. Historically,konenkiwas associated with wealthy middle-class housewives in Japan, i.e., it was a "luxury disease" that women from traditional, inter-generational rural households did not report. Menopause in Japan was viewed as a symptom of the inevitable process of aging, rather than a "revolutionary transition", or a "deficiency disease" in need of management.[109]
As of 2005, in Japanese culture, reporting of vasomotor symptoms has been on the increase, with research finding that of 140 Japanese participants, hot flashes were prevalent in 22.1%.[110]This was almost double that of 20 years prior.[111]Whilst the exact cause for this is unknown, possible contributing factors include dietary changes, increased medicalisation of middle-aged women and increased media attention on the subject.[111]However, reporting of vasomotor symptoms is still "significantly" lower than in North America.[112]
Additionally, while most women in the United States apparently have a negative view of menopause as a time of deterioration or decline, some studies seem to indicate that women from some Asian cultures have an understanding of menopause that focuses on a sense of liberation and celebrates the freedom from the risk of pregnancy.[113]Diverging from these conclusions, one study appeared to show that many American women "experience this time as one of liberation andself-actualization".[114]
In some women, menopause may bring about a sense of loss related to the end of fertility. In addition, this change often aligns with other stressors, such as the responsibility of looking after elderly parents or dealing with the emotional challenges of "empty nest syndrome"when children move out of the family home. This situation can be accentuated in cultures wherebeing older is negatively perceived.
Impact on work
[edit]Midlife is typically a life stage when men and women may be dealing with demanding life events and responsibilities, such as work, health problems, and caring roles. For example, in 2018 in the UK women aged 45–54 report more work-related stress than men or women of any other age group.[115]Hot flashes are often reported to be particularly distressing at work and lead to embarrassment and worry about potentialstigmatisation.[116]A June 2023 study by the Mayo Clinic estimated an annual loss of $1.8 billion in the United States due to workdays missed as a result of menopause symptoms.[117]This was one of the largest studies to date examining the impact of menopause symptoms on work outcomes. The research concluded there was a strong need to improve medical treatment for menopausal women and make the workplace environment more supportive to avoid such productivity losses.
Etymology
[edit]Menopause literally means the "end of monthly cycles" (the end ofmonthly periodsormenstruation), from the Greek wordpausis( "pause" ) andmēn( "month" ). This is a medical coinage; the Greek word formensesis actually different. In Ancient Greek, the menses were described in the plural,ta emmēnia( "the monthlies" ), and its modern descendant has been clipped tota emmēna.The Modern Greek medical term isemmenopausisinKatharevousaoremmenopausiinDemotic Greek.The Ancient Greeks did not produce medical concepts about any symptoms associated with end of menstruation and did not use a specific word to refer to this time of a woman's life. The word menopause was invented by French doctors at the beginning of the nineteenth century. Greek etymology was reconstructed at this time and it was the Parisian student doctor Charles-Pierre-Louis de Gardanne who invented the a variation of the word in 1812, which was edited to its final French form in 1821.[118]
Some of them noted that peasant women had no complaints about the end of menses, while urban middle-class women had many troubling symptoms. Doctors at this time considered the symptoms to be the result of urban lifestyles of sedentary behaviour, alcohol consumption, too much time indoors, and over-eating, with a lack of fresh fruit and vegetables.[119]
The word "menopause" was coined specifically for human females, where the end of fertility is traditionally indicated by the permanent stopping of monthly menstruations. However, menopause exists in some other animals, many of which do not have monthly menstruation;[120]in this case, the term means a natural end to fertility that occurs before the end of the natural lifespan.
In popular culture, law and politics
[edit]In the 21st century, celebrities have spoken out about their experiences of the menopause, which has led to it becoming less of a taboo as it has boosted awareness of the debilitating symptoms. Subsequently, TV shows have been running features on the menopause to help women experiencing symptoms. In the UKLorraine Kellyhas been an advocate for getting women to speak about their experiences including sharing her own. This has led to an increase in women seeking treatment such as HRT.[121]Davina McCallalso led an awareness campaign based on a documentary onChannel 4.[122]
In the UK,Carolyn Harrissponsored the Menopause (Support and Services) Bill in June 2021. It was to exempt hormone replacement therapy from National Health Serviceprescription chargesand to make provisions about menopause support and services, including public education and communication in supporting perimenopausal and post-menopausal women, and to raise awareness of menopause and its effects. The bill was withdrawn on 29 October 2021.[123]
In the US,David McKinley,Republican from West Virginia introduced the Menopause Research Act in September 2022 for $100 million in 2023 and 2024, but it stalled.[124]
Other animals
[edit]Few animals have a menopause: humans are joined by just five other species in which females live substantially longer than their ability to reproduce. The others are allcetaceans:beluga whales,[125]narwhals,[125]orcas,[126]false killer whales[127]andshort-finned pilot whales.[128]
Menopause has been reported in a variety of other vertebrate species, but these examples tend to be from captive individuals, and thus are not necessarily representative of what happens in natural populations in the wild. Menopause in captivity has been observed in several species of nonhumanprimates,[120]includingrhesus monkeys[129]andchimpanzees.[130]Some research suggests that wild chimpanzees do not experience menopause, as their fertility declines are associated with declines in overall health.[131]Menopause has been reported in elephants in captivity[132]andguppies.[133]Dogs do not experience menopause; thecanine estrus cyclesimply becomes irregular and infrequent. Although older female dogs are not considered good candidates for breeding, offspring have been produced by older animals, seeCanine reproduction.Similar observations have been made in cats.[134]
Life historiesshow a varying degree ofsenescence;rapid senescing organisms (e.g.,Pacific salmonandannual plants) do not have a post-reproductive life-stage. Gradual senescence is exhibited by allplacental mammalianlife histories.[original research?]
Evolution
[edit]There are various theories on the origin and process of theevolution of the menopause.These attempt to suggest evolutionary benefits to the human species stemming from the cessation of women's reproductive capability before the end of their natural lifespan. It is conjectured that in highly social groupsnatural selectionfavors females that stop reproducing and devote that post-reproductive life span to continuing to care for existing offspring, both their own and those of others to whom they are related, especially their granddaughters and grandsons.[135]
See also
[edit]- European Menopause and Andropause Society
- Menopause in the workplace
- Menopause in incarceration
- Pregnancy over age 50
- Biological clock
- Evolution of menopause
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External links
[edit]![](https://upload.wikimedia.org/wikipedia/en/thumb/4/4a/Commons-logo.svg/30px-Commons-logo.svg.png)
- Menopause: MedlinePlus
- What Is Menopause?,National Institute on Aging
- Menopause & Me,The North American Menopause Society