RBBP7

RBBP7
Available structures
PDB	Ortholog search:PDBeRCSB
List of PDB id codes
	3CFS,3CFV
Identifiers
Aliases	RBBP7,RbAp46, retinoblastoma binding protein 7, RB binding protein 7, chromatin remodeling factor
External IDs	OMIM:300825;MGI:1194910;HomoloGene:55702;GeneCards:RBBP7;OMA:RBBP7 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	16,870,362bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	161,562,088bp
RNA expressionpattern
	Top expressed in
	oocyte; ; secondary oocyte; ; right adrenal gland; ; right adrenal cortex; ; left adrenal cortex; ; corpus epididymis; ; seminal vesicula; ; endothelial cell; ; right testis; ; left ovary;
	Top expressed in
	primitive streak; ; migratory enteric neural crest cell; ; medullary collecting duct; ; condyle; ; ureter; ; Paneth cell; ; internal carotid artery; ; fossa; ; external carotid artery; ; vas deferens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; RNA binding; histone deacetylase activity;
Cellular component	NuRD complex; ESC/E(Z) complex; nucleus; nucleoplasm; cytosol;
Biological process	regulation of transcription, DNA-templated; response to steroid hormone; cellular heat acclimation; negative regulation of transcription by RNA polymerase II; CENP-A containing chromatin assembly; transcription, DNA-templated; multicellular organism development; DNA replication; negative regulation of gene expression, epigenetic; negative regulation of cell growth; cell population proliferation; negative regulation of transcription, DNA-templated; regulation of signal transduction by p53 class mediator; histone deacetylation; post-translational protein modification; negative regulation of G0 to G1 transition; chromatin organization;
	Sources:Amigo/QuickGO
Orthologs
	5931
	245688
	ENSG00000102054
	ENSMUSG00000031353
	Q16576
	Q60973
	NM_001198719; NM_002893
	NM_009031
	NP_001185648; NP_002884
	NP_033057
	Wikidata
View/Edit Human	View/Edit Mouse

Histone-binding protein RBBP7is aproteinthat in humans is encoded by theRBBP7gene.^[5]

Function[edit]

This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily ofWD-repeatproteins. It is found among several proteins that binds directly toretinoblastoma protein,which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation.^[6]

Interactions[edit]

RBBP7 has been shown tointeractwith:

References[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000102054–Ensembl,May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000031353–Ensembl,May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^^a ^bQian YW,Lee EY(Dec 1995)."Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast".J Biol Chem.270(43): 25507–25513.doi:10.1074/jbc.270.43.25507.PMID 7503932.
^"Entrez Gene: RBBP7 retinoblastoma binding protein 7".
^^a ^bYarden RI, Brody LC (April 1999)."BRCA1 interacts with components of the histone deacetylase complex".Proc. Natl. Acad. Sci. U.S.A.96(9): 4983–8.Bibcode:1999PNAS...96.4983Y.doi:10.1073/pnas.96.9.4983.PMC21803.PMID 10220405.
^Chen GC, Guan LS, Yu JH, Li GC, Choi Kim HR, Wang ZY (June 2001). "Rb-associated protein 46 (RbAp46) inhibits transcriptional transactivation mediated by BRCA1".Biochem. Biophys. Res. Commun.284(2): 507–14.doi:10.1006/bbrc.2001.5003.PMID 11394910.
^Yarden RI, Brody LC (2001)."Identification of proteins that interact with BRCA1 by Far-Western library screening".J. Cell. Biochem.83(4): 521–31.doi:10.1002/jcb.1257.PMID 11746496.S2CID 29703139.
^Feng Q, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Zhang Y (January 2002)."Identification and functional characterization of the p66/p68 components of the MeCP1 complex".Mol. Cell. Biol.22(2): 536–46.doi:10.1128/mcb.22.2.536-546.2002.PMC139742.PMID 11756549.
^^a ^bYao YL, Yang WM (October 2003)."The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity".J. Biol. Chem.278(43): 42560–8.doi:10.1074/jbc.M302955200.PMID 12920132.
^Ng HH, Zhang Y, Hendrich B, Johnson CA, Turner BM, Erdjument-Bromage H, Tempst P, Reinberg D, Bird A (September 1999). "MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex".Nat. Genet.23(1): 58–61.doi:10.1038/12659.hdl:1842/684.PMID 10471499.S2CID 6147725.
^^a ^b ^cZhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (August 1999)."Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation".Genes Dev.13(15): 1924–35.doi:10.1101/gad.13.15.1924.PMC316920.PMID 10444591.
^Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D (May 1997)."Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex".Cell.89(3): 357–64.doi:10.1016/s0092-8674(00)80216-0.PMID 9150135.
^^a ^bZhang Y, Sun ZW, Iratni R, Erdjument-Bromage H, Tempst P, Hampsey M, Reinberg D (June 1998)."SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex".Mol. Cell.1(7): 1021–31.doi:10.1016/s1097-2765(00)80102-1.PMID 9651585.
^^a ^bKuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D (February 2002)."Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)".Mol. Cell. Biol.22(3): 835–48.doi:10.1128/mcb.22.3.835-848.2002.PMC133546.PMID 11784859.

Further reading[edit]

Huang S, Lee WH, Lee EY (1991). "A cellular protein that competes with SV40 T antigen for binding to the retinoblastoma gene product".Nature.350(6314): 160–162.Bibcode:1991Natur.350..160H.doi:10.1038/350160a0.PMID 2005966.S2CID 4345233.
Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D (1997)."Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex".Cell.89(3): 357–364.doi:10.1016/S0092-8674(00)80216-0.PMID 9150135.
Verreault A, Kaufman PD, Kobayashi R, Stillman B (1998)."Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase".Curr. Biol.8(2): 96–108.Bibcode:1998CBio....8...96V.doi:10.1016/S0960-9822(98)70040-5.PMID 9427644.S2CID 201273.
Zhang Y, Sun ZW, Iratni R, Erdjument-Bromage H, Tempst P, Hampsey M, Reinberg D (1998)."SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex".Mol. Cell.1(7): 1021–1031.doi:10.1016/S1097-2765(00)80102-1.PMID 9651585.
Guan LS, Rauchman M, Wang ZY (1998)."Induction of Rb-associated protein (RbAp46) by Wilms' tumor suppressor WT1 mediates growth inhibition".J. Biol. Chem.273(42): 27047–27050.doi:10.1074/jbc.273.42.27047.PMID 9765217.
Zhang Y, LeRoy G, Seelig HP, Lane WS, Reinberg D (1998)."The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities".Cell.95(2): 279–289.doi:10.1016/S0092-8674(00)81758-4.PMID 9790534.S2CID 18786866.
Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL (1998). "Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex".Nature.395(6705): 917–921.Bibcode:1998Natur.395..917T.doi:10.1038/27699.PMID 9804427.S2CID 4355885.
Yarden RI, Brody LC (1999)."BRCA1 interacts with components of the histone deacetylase complex".Proc. Natl. Acad. Sci. U.S.A.96(9): 4983–4988.Bibcode:1999PNAS...96.4983Y.doi:10.1073/pnas.96.9.4983.PMC21803.PMID 10220405.
Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (1999)."Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation".Genes Dev.13(15): 1924–1935.doi:10.1101/gad.13.15.1924.PMC316920.PMID 10444591.
Wade PA, Gegonne A, Jones PL, Ballestar E, Aubry F, Wolffe AP (1999). "Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation".Nat. Genet.23(1): 62–66.doi:10.1038/12664.PMID 10471500.S2CID 52868103.
Zhang Q, Vo N, Goodman RH (2000)."Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB".Mol. Cell. Biol.20(14): 4970–4978.doi:10.1128/MCB.20.14.4970-4978.2000.PMC85947.PMID 10866654.
Humphrey GW, Wang Y, Russanova VR, Hirai T, Qin J, Nakatani Y, Howard BH (2001)."Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1".J. Biol. Chem.276(9): 6817–6824.doi:10.1074/jbc.M007372200.PMID 11102443.
Skowyra D, Zeremski M, Neznanov N, Li M, Choi Y, Uesugi M, Hauser CA, Gu W, Gudkov AV, Qin J (2001)."Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex".J. Biol. Chem.276(12): 8734–8739.doi:10.1074/jbc.M007664200.PMID 11118440.
Chen GC, Guan LS, Yu JH, Li GC, Choi Kim HR, Wang ZY (2001). "Rb-associated protein 46 (RbAp46) inhibits transcriptional transactivation mediated by BRCA1".Biochem. Biophys. Res. Commun.284(2): 507–514.doi:10.1006/bbrc.2001.5003.PMID 11394910.
Yarden RI, Brody LC (2002)."Identification of proteins that interact with BRCA1 by Far-Western library screening".J. Cell. Biochem.83(4): 521–531.doi:10.1002/jcb.1257.PMID 11746496.S2CID 29703139.
Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D (2002)."Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)".Mol. Cell. Biol.22(3): 835–848.doi:10.1128/MCB.22.3.835-848.2002.PMC133546.PMID 11784859.
Vaute O, Nicolas E, Vandel L, Trouche D (2002)."Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases".Nucleic Acids Res.30(2): 475–481.doi:10.1093/nar/30.2.475.PMC99834.PMID 11788710.
Saito M, Ishikawa F (2002)."The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2".J. Biol. Chem.277(38): 35434–35439.doi:10.1074/jbc.M203455200.PMID 12124384.
Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D (2002)."Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein".Genes Dev.16(22): 2893–2905.doi:10.1101/gad.1035902.PMC187479.PMID 12435631.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000102054–Ensembl,May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031353–Ensembl,May 2017

[3] "Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7503932-5] Qian YW,Lee EY(Dec 1995)."Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast".J Biol Chem.270(43): 25507–25513.doi:10.1074/jbc.270.43.25507.PMID 7503932.

[entrez-6] "Entrez Gene: RBBP7 retinoblastoma binding protein 7".

[pmid10220405-7] Yarden RI, Brody LC (April 1999)."BRCA1 interacts with components of the histone deacetylase complex".Proc. Natl. Acad. Sci. U.S.A.96(9): 4983–8.Bibcode:1999PNAS...96.4983Y.doi:10.1073/pnas.96.9.4983.PMC21803.PMID 10220405.

[pmid11394910-8] Chen GC, Guan LS, Yu JH, Li GC, Choi Kim HR, Wang ZY (June 2001). "Rb-associated protein 46 (RbAp46) inhibits transcriptional transactivation mediated by BRCA1".Biochem. Biophys. Res. Commun.284(2): 507–14.doi:10.1006/bbrc.2001.5003.PMID 11394910.

[pmid11746496-9] Yarden RI, Brody LC (2001)."Identification of proteins that interact with BRCA1 by Far-Western library screening".J. Cell. Biochem.83(4): 521–31.doi:10.1002/jcb.1257.PMID 11746496.S2CID 29703139.

[pmid11756549-10] Feng Q, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Zhang Y (January 2002)."Identification and functional characterization of the p66/p68 components of the MeCP1 complex".Mol. Cell. Biol.22(2): 536–46.doi:10.1128/mcb.22.2.536-546.2002.PMC139742.PMID 11756549.

[pmid12920132-11] Yao YL, Yang WM (October 2003)."The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity".J. Biol. Chem.278(43): 42560–8.doi:10.1074/jbc.M302955200.PMID 12920132.

[pmid10471499-12] Ng HH, Zhang Y, Hendrich B, Johnson CA, Turner BM, Erdjument-Bromage H, Tempst P, Reinberg D, Bird A (September 1999). "MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex".Nat. Genet.23(1): 58–61.doi:10.1038/12659.hdl:1842/684.PMID 10471499.S2CID 6147725.

[pmid10444591-13] Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (August 1999)."Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation".Genes Dev.13(15): 1924–35.doi:10.1101/gad.13.15.1924.PMC316920.PMID 10444591.

[pmid9150135-14] Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D (May 1997)."Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex".Cell.89(3): 357–64.doi:10.1016/s0092-8674(00)80216-0.PMID 9150135.

[pmid9651585-15] Zhang Y, Sun ZW, Iratni R, Erdjument-Bromage H, Tempst P, Hampsey M, Reinberg D (June 1998)."SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex".Mol. Cell.1(7): 1021–31.doi:10.1016/s1097-2765(00)80102-1.PMID 9651585.

[pmid11784859-16] Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D (February 2002)."Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)".Mol. Cell. Biol.22(3): 835–48.doi:10.1128/mcb.22.3.835-848.2002.PMC133546.PMID 11784859.

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