60S acidic ribosomal protein P0

RPLP0
Available structures PDB Ortholog search:PDBeRCSB List of PDB id codes 4V6X,5AJ0,3J92,4V5Z,%%s4V5Z,5AJ0,4V6X,3J92
Identifiers
Aliases	RPLP0,L10E, LP0, P0, PRLP0, RPP0, ribosomal protein lateral stalk subunit P0
External IDs	OMIM:180510;MGI:1927636;HomoloGene:6517;GeneCards:RPLP0;OMA:RPLP0 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q24.23 Start 120,196,699bp End 120,201,235bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 F Start 115,697,526bp End 115,701,786bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in gonad stromal cell of endometrium ventricular zone mucosa of esophagus skin of leg islet of Langerhans ganglionic eminence right uterine tube skin of abdomen right ovary Top expressed in epiblast ventricular zone embryo lip embryo ganglionic eminence zone of skin esophagus urinary bladder lens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding structural constituent of ribosome RNA binding large ribosomal subunit rRNA binding peptide binding Cellular component ribosome focal adhesion intracellular anatomical structure cytoplasmic ribonucleoprotein granule cytosolic large ribosomal subunit extracellular exosome cytoplasm nucleus endoplasmic reticulum cytosol membrane postsynaptic density postsynapse ribonucleoprotein complex dendrite synapse Biological process ribosome biogenesis viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay protein biosynthesis rRNA processing viral process interleukin-12-mediated signaling pathway ribosomal large subunit assembly cytoplasmic translation lactation response to selenium ion cellular response to cAMP cellular response to interleukin-4 cellular response to Thyroid stimulating hormone cellular response to phorbol 13-acetate 12-myristate Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 6175 11837 Ensembl ENSG00000089157 ENSMUSG00000067274 UniProt P05388 P14869 RefSeq (mRNA) NM_053275 NM_001002 NM_007475 RefSeq (protein) NP_000993 NP_444505 NP_000993.1 NP_444505.1 NP_031501 Location (UCSC) Chr 12: 120.2 – 120.2 Mb Chr 5: 115.7 – 115.7 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

60S acidic ribosomal protein P0is aproteinthat in humans is encoded by theRPLP0gene.

Ribosomescatalyzeprotein synthesisand consist of a small40Ssubunit and a large60Ssubunit. Together these subunits are composed of 4RNAspecies and approximately 80 structurally distinct proteins. This gene encodes aribosomal proteinthat is a component of the 60S subunit. The protein, which is the functional equivalent of the E. coliL10 ribosomal protein,belongs to the L10P family of ribosomal proteins. It is a neutralphosphoproteinwith a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteinsP1andP2.The P0 protein can interact with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in thecytoplasm.Transcript variants derived fromalternative splicingexist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processedpseudogenesof this gene dispersed through the genome.

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins".Biochem. Cell Biol.73(11–12): 933–47.doi:10.1139/o95-101.PMID8722009.
• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin".J. Infect.24(3): 317–20.doi:10.1016/S0163-4453(05)80037-4.PMID1602151.
• Rich BE, Steitz JA (1988)."Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly".Mol. Cell. Biol.7(11): 4065–74.doi:10.1128/mcb.7.11.4065.PMC368077.PMID3323886.
• Towbin H, Ramjoué HP, Kuster H, et al. (1982)."Monoclonal antibodies against eucaryotic ribosomes. Use to characterize a ribosomal protein not previously identified and antigenically related to the acidic phosphoproteins P1/P2".J. Biol. Chem.257(21): 12709–15.doi:10.1016/S0021-9258(18)33569-5.PMID6182142.
• Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank".Gene.150(2): 243–50.doi:10.1016/0378-1119(94)90433-2.PMID7821789.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".Gene.138(1–2): 171–4.doi:10.1016/0378-1119(94)90802-8.PMID8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".Gene.200(1–2): 149–56.doi:10.1016/S0378-1119(97)00411-3.PMID9373149.
• <Please add first missing authors to populate metadata.> (1999)."Toward a complete human genome sequence".Genome Res.8(11): 1097–108.doi:10.1101/gr.8.11.1097.PMID9847074.
• Tchórzewski M, Boldyreff B, Issinger O, Grankowski N (2000). "Analysis of the protein-protein interactions between the human acidic ribosomal P-proteins: evaluation by the two hybrid system".Int. J. Biochem. Cell Biol.32(7): 737–46.doi:10.1016/S1357-2725(00)00017-0.PMID10856704.
• Chan SH, Hung FS, Chan DS, Shaw PC (2001)."Trichosanthin interacts with acidic ribosomal proteins P0 and P1 and mitotic checkpoint protein MAD2B".Eur. J. Biochem.268(7): 2107–12.doi:10.1046/j.1432-1327.2001.02091.x.PMID11277934.
• Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders".Genomics.72(3): 223–30.doi:10.1006/geno.2000.6470.PMID11401437.
• Andersen JS, Lyon CE, Fox AH, et al. (2002)."Directed proteomic analysis of the human nucleolus".Curr. Biol.12(1): 1–11.Bibcode:2002CBio...12....1A.doi:10.1016/S0960-9822(01)00650-9.PMID11790298.S2CID14132033.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
• Tchórzewski M, Krokowski D, Rzeski W, et al. (2003). "The subcellular distribution of the human ribosomal" stalk "components: P1, P2 and P0 proteins".Int. J. Biochem. Cell Biol.35(2): 203–11.doi:10.1016/S1357-2725(02)00133-4.PMID12479870.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36(1): 40–5.doi:10.1038/ng1285.PMID14702039.
• Shu H, Chen S, Bi Q, et al. (2004)."Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line".Mol. Cell. Proteomics.3(3): 279–86.doi:10.1074/mcp.D300003-MCP200.PMID14729942.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway".Nat. Cell Biol.6(2): 97–105.doi:10.1038/ncb1086.PMID14743216.S2CID11683986.
• Villacé P, Marión RM, Ortín J (2004)."The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs".Nucleic Acids Res.32(8): 2411–20.doi:10.1093/nar/gkh552.PMC419443.PMID15121898.