40S ribosomal protein S18

RPS18
Available structures PDB Ortholog search:PDBeRCSB List of PDB id codes 4UG0,4V6X,5A2Q,5AJ0,4KZY,3J7R,4D61,4KZX,4D5L,4V5Z,5FLX,4UJD,3J7P,4KZZ,4UJE,4UJC
Identifiers
Aliases	RPS18,D6S218E, HKE3, KE-3, KE3, S18, ribosomal protein S18
External IDs	OMIM:180473;MGI:98146;HomoloGene:88764;GeneCards:RPS18;OMA:RPS18 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.32 Start 33,272,075bp End 33,276,511bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 B1|17 17.98 cM Start 34,170,973bp End 34,174,975bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in left ovary right ovary skin of leg skin of abdomen canal of the cervix lymph node ectocervix uterine tube lactiferous gland vagina Top expressed in ventricular zone lip blastocyst yolk sac morula neural layer of retina right kidney tail of embryo genital tubercle granulocyte More reference expression data BioGPS n/a
Gene ontology Molecular function rRNA binding protein binding nucleic acid binding RNA binding structural constituent of ribosome protein kinase binding Cellular component cytoplasm ribosome membrane focal adhesion intracellular anatomical structure small ribosomal subunit extracellular exosome nucleus nucleoplasm extracellular matrix cytosol cytosolic small ribosomal subunit postsynaptic density synapse Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay protein biosynthesis ribosome biogenesis rRNA processing Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 6222 20084 Ensembl ENSG00000226225 ENSG00000096150 ENSG00000231500 ENSG00000235650 ENSG00000223367 ENSG00000227794 ENSMUSG00000008668 UniProt P62269 P62270 RefSeq (mRNA) NM_022551 NM_011296 NM_138946 RefSeq (protein) NP_072045 NP_035426 Location (UCSC) Chr 6: 33.27 – 33.28 Mb Chr 17: 34.17 – 34.17 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

40S ribosomal protein S18is aproteinthat in humans is encoded by theRPS18gene.

Ribosomes,theorganellesthatcatalyzeprotein synthesis,consist of asmall 40S subunitand alarge 60S subunit.Together these subunits are composed of 4RNAspecies and approximately 80 structurally distinct proteins. This gene encodes aribosomal proteinthat is a component of the 40S subunit. The protein belongs to the S13P family of ribosomal proteins. It is located in thecytoplasm.The gene product of theE. coliortholog (ribosomal protein S13) is involved in the binding offMet-tRNA, and thus, in the initiation oftranslation.This gene is an ortholog ofmouseKe3. As is typical for genes encoding ribosomal proteins, there are multiple processedpseudogenesof this gene dispersed through the genome.

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins".Biochem. Cell Biol.73(11–12): 933–47.doi:10.1139/o95-101.PMID8722009.
• Chan YL, Paz V, Wool IG (1991)."The primary structure of rat ribosomal protein S18".Biochem. Biophys. Res. Commun.178(3): 1212–8.doi:10.1016/0006-291X(91)91022-5.PMC335161.PMID1872840.
• Chassin D, Bénifla JL, Delattre C, et al. (1994). "Identification of genes overexpressed in tumors through preferential expression screening in trophoblasts".Cancer Res.54(19): 5217–23.PMID7923143.
• Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996)."Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry".Eur. J. Biochem.239(1): 144–9.doi:10.1111/j.1432-1033.1996.0144u.x.PMID8706699.
• Andersen JS, Lyon CE, Fox AH, et al. (2002)."Directed proteomic analysis of the human nucleolus".Curr. Biol.12(1): 1–11.Bibcode:2002CBio...12....1A.doi:10.1016/S0960-9822(01)00650-9.PMID11790298.S2CID14132033.
• Mishra-Gorur K, Singer HA, Castellot JJ (2002)."The S18 ribosomal protein is a putative substrate for Ca2+/calmodulin-activated protein kinase II".J. Biol. Chem.277(37): 33537–40.doi:10.1074/jbc.C200342200.PMID12145273.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003)."The DNA sequence and analysis of human chromosome 6".Nature.425(6960): 805–11.Bibcode:2003Natur.425..805M.doi:10.1038/nature02055.PMID14574404.
• Kusui K, Sasaki H, Adachi R, et al. (2005). "Ribosomal protein S18 identified as a cofilin-binding protein by using phage display library".Mol. Cell. Biochem.262(1–2): 187–93.doi:10.1023/B:MCBI.0000038234.35936.1c.PMID15532723.S2CID30534195.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics".Nature.433(7021): 77–83.Bibcode:2005Natur.433...77A.doi:10.1038/nature03207.PMID15635413.S2CID4344740.
• Yu Y, Ji H, Doudna JA, Leary JA (2005)."Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes".Protein Sci.14(6): 1438–46.doi:10.1110/ps.041293005.PMC2253395.PMID15883184.

External links

• Overview of all the structural information available in thePDBforUniProt:P62269(40S ribosomal protein S18) at thePDBe-KB.