40S ribosomal protein S19
(Redirected fromRPS19)
40S ribosomal protein S19is aproteinthat in humans is encoded by theRPS19gene.[5][6]
Function
[edit]Ribosomes,theorganellesthatcatalyzeprotein synthesis,consist of asmall 40S subunitand alarge 60S subunit.Together these subunits are composed of 4RNAspecies and approximately 80 structurally distinct proteins. This gene encodes aribosomal proteinthat is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in thecytoplasm.As is typical for genes encoding ribosomal proteins, there are multiple processedpseudogenesof this gene dispersed through the genome.[6]
Clinical significance
[edit]Mutations in this gene causeDiamond–Blackfan anemia(DBA), a constitutionalerythroblastopeniacharacterized by absent or decreasederythroidprecursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoieticdifferentiationandproliferation,in addition to its ribosomal function. Higher expression levels of this gene in some primarycolon carcinomascompared to matched normal colon tissues has been observed.[6]
Interactions
[edit]Ribosomal protein S19 has been shown tointeractwithbasic fibroblast growth factor.[7]RPS19 is also secreted extracellularly and its extracellular oligomers (crosslinked by thetransglutaminaseCoagulation factor XIII) is also known to bind and probably inhibitMacrophage migration inhibitory factor;though S19 oligomers themselves share MCIP's function as another very strong macrophage chemoattractant and bind to anaphylotoxin C5 receptor[8]
References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000105372–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000040952–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (August 1998)."A map of 75 human ribosomal protein genes".Genome Res.8(5): 509–23.doi:10.1101/gr.8.5.509.PMID9582194.
- ^abc"Entrez Gene: RPS19 ribosomal protein S19".
- ^Soulet F, Al Saati T, Roga S, Amalric F, Bouche G (November 2001). "Fibroblast growth factor-2 interacts with free ribosomal protein S19".Biochem. Biophys. Res. Commun.289(2): 591–6.doi:10.1006/bbrc.2001.5960.PMID11716516.
- ^Molecular Basis of Cell and Developmental Biology: Ana-Maria Filip, Jörg Klug, Sevil Cayli, Suada Fröhlich, Tamara Henke, Philipp Lacher, Regina Eickhoff, Patrick Bulau, Monika Linder, Christine Carlsson-Skwirut, Lin Leng, Richard Bucala, Sandra Kraemer, Jürgen Bernhagen, and Andreas Meinhardt. "Ribosomal Protein S19 Interacts with Macrophage Migration Inhibitory Factor and Attenuates Its Pro-inflammatory Function" 'J. Biol. Chem.2009 284: 7977–7985. First Published on January 20, 2009, doi:10.1074/jbc.M808620200
Further reading
[edit]- Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins".Biochem. Cell Biol.73(11–12): 933–47.doi:10.1139/o95-101.PMID8722009.
- Morimoto K, Lin S, Sakamoto K (2007). "The functions of RPS19 and their relationship to Diamond-Blackfan anemia: a review".Mol. Genet. Metab.90(4): 358–62.doi:10.1016/j.ymgme.2006.11.004.PMID17178250.
- Yamamoto T (2007). "Roles of the ribosomal protein S19 dimer and the C5a receptor in pathophysiological functions of phagocytic leukocytes".Pathol. Int.57(1): 1–11.doi:10.1111/j.1440-1827.2007.02049.x.PMID17199736.S2CID22946804.
- Kondoh N, Schweinfest CW, Henderson KW, Papas TS (1992). "Differential expression of S19 ribosomal protein, laminin-binding protein, and human lymphocyte antigen class I messenger RNAs associated with colon carcinoma progression and differentiation".Cancer Res.52(4): 791–6.PMID1339304.
- Vladimirov SN, Ivanov AV, Karpova GG, Musolyamov AK, Egorov TA, Thiede B, Wittmann-Liebold B, Otto A (1996)."Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry".Eur. J. Biochem.239(1): 144–9.doi:10.1111/j.1432-1033.1996.0144u.x.PMID8706699.
- Draptchinskaia N, Gustavsson P, Andersson B, Pettersson M, Willig TN, Dianzani I, Ball S, Tchernia G, Klar J, Matsson H, Tentler D, Mohandas N, Carlsson B, Dahl N (1999). "The gene encoding ribosomal protein S19 is mutated in Diamond-Blackfan anaemia".Nat. Genet.21(2): 169–75.doi:10.1038/5951.PMID9988267.S2CID26664929.
- Willig TN, Draptchinskaia N, Dianzani I, Ball S, Niemeyer C, Ramenghi U, Orfali K, Gustavsson P, Garelli E, Brusco A, Tiemann C, Pérignon JL, Bouchier C, Cicchiello L, Dahl N, Mohandas N, Tchernia G (2000). "Mutations in ribosomal protein S19 gene and diamond blackfan anemia: wide variations in phenotypic expression".Blood.94(12): 4294–306.PMID10590074.
- Matsson H, Klar J, Draptchinskaia N, Gustavsson P, Carlsson B, Bowers D, de Bont E, Dahl N (2000). "Truncating ribosomal protein S19 mutations and variable clinical expression in Diamond-Blackfan anemia".Hum. Genet.105(5): 496–500.doi:10.1007/s004390051136.PMID10598818.
- Tentler D, Gustavsson P, Elinder G, Eklöf O, Gordon L, Mandel A, Dahl N (2000)."A microdeletion in 19q13.2 associated with mental retardation, skeletal malformations, and Diamond-Blackfan anaemia suggests a novel contiguous gene syndrome".J. Med. Genet.37(2): 128–31.doi:10.1136/jmg.37.2.128.PMC1734524.PMID10662814.
- Ramenghi U, Campagnoli MF, Garelli E, Carando A, Brusco A, Bagnara GP, Strippoli P, Izzi GC, Brandalise S, Riccardi R, Dianzani I (2001). "Diamond-Blackfan anemia: report of seven further mutations in the RPS19 gene and evidence of mutation heterogeneity in the Italian population".Blood Cells Mol. Dis.26(5): 417–22.doi:10.1006/bcmd.2000.0324.PMID11112378.
- Nishimura T, Horino K, Nishiura H, Shibuya Y, Hiraoka T, Tanase S, Yamamoto T (2001). "Apoptotic cells of an epithelial cell line, AsPC-1, release monocyte chemotactic S19 ribosomal protein dimer".J. Biochem.129(3): 445–54.doi:10.1093/oxfordjournals.jbchem.a002876.PMID11226885.
- Soulet F, Al Saati T, Roga S, Amalric F, Bouche G (2002). "Fibroblast growth factor-2 interacts with free ribosomal protein S19".Biochem. Biophys. Res. Commun.289(2): 591–6.doi:10.1006/bbrc.2001.5960.PMID11716516.
- Shibuya Y, Shiokawa M, Nishiura H, Nishimura T, Nishino N, Okabe H, Takagi K, Yamamoto T (2001)."Identification of Receptor-Binding Sites of Monocyte Chemotactic S19 Ribosomal Protein Dimer".Am. J. Pathol.159(6): 2293–301.doi:10.1016/S0002-9440(10)63079-9.PMC1850605.PMID11733378.
- Li B, Sun M, He B, Yu J, Zhang YD, Zhang YL (2004)."Identification of differentially expressed genes in human uterine leiomyomas using differential display".Cell Res.12(1): 39–45.doi:10.1038/sj.cr.7290108.PMID11942409.
- Da Costa L, Tchernia G, Gascard P, Lo A, Meerpohl J, Niemeyer C, Chasis JA, Fixler J, Mohandas N (2004)."Nucleolar localization of RPS19 protein in normal cells and mislocalization due to mutations in the nucleolar localization signals in 2 Diamond-Blackfan anemia patients: potential insights into pathophysiology".Blood.101(12): 5039–45.doi:10.1182/blood-2002-12-3878.PMID12586610.
- Shrestha A, Shiokawa M, Nishimura T, Nishiura H, Tanaka Y, Nishino N, Shibuya Y, Yamamoto T (2003)."Switch Moiety in Agonist/Antagonist Dual Effect of S19 Ribosomal Protein Dimer on Leukocyte Chemotactic C5a Receptor".Am. J. Pathol.162(4): 1381–8.doi:10.1016/S0002-9440(10)63934-X.PMC1851224.PMID12651630.
- Proust A, Da Costa L, Rince P, Landois A, Tamary H, Zaizov R, Tchernia G, Delaunay J (2003). "Ten novel Diamond-Blackfan anemia mutations and three polymorphisms within the rps19 gene".Hematol. J.4(2): 132–6.doi:10.1038/sj.thj.6200230.PMID12750732.