40S ribosomal protein S9

RPS9
Available structures PDB Ortholog search:PDBeRCSB List of PDB id codes 4UG0,4V6X,5A2Q,5AJ0,4KZY,3J7R,4D61,4KZX,4D5L,5FLX,4UJD,3J7P,4KZZ,4UJE,4UJC
Identifiers
Aliases	RPS9,S9, ribosomal protein S9
External IDs	OMIM:603631;MGI:1924096;HomoloGene:68145;GeneCards:RPS9;OMA:RPS9 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.42 Start 54,200,809bp End 54,249,003bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 A1 Start 3,706,992bp End 3,709,896bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in monocyte left ovary right ovary right uterine tube skin of abdomen canal of the cervix skin of leg lymph node appendix gallbladder Top expressed in medial ganglionic eminence ventricular zone transitional epithelium of urinary bladder efferent ductule blastocyst fetal liver hematopoietic progenitor cell thymus maxillary prominence lip mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function rRNA binding structural constituent of ribosome translation regulator activity protein binding RNA binding Cellular component cytoplasm cytosol ribosome membrane focal adhesion intracellular anatomical structure nucleolus small ribosomal subunit extracellular exosome nucleus nucleoplasm cytosolic small ribosomal subunit synapse ribonucleoprotein complex Biological process positive regulation of translational fidelity viral transcription SRP-dependent cotranslational protein targeting to membrane positive regulation of cell population proliferation translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay protein biosynthesis rRNA processing Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 6203 76846 Ensembl ENSG00000274646 ENSG00000277359 ENSG00000274950 ENSG00000274626 ENSG00000275323 ENSG00000278270 ENSG00000278081 ENSG00000274005 ENSG00000277079 ENSG00000170889 ENSMUSG00000006333 UniProt P46781 Q6ZWN5 RefSeq (mRNA) NM_001013 NM_001321701 NM_001321702 NM_001321704 NM_001321705 NM_001321706 NM_029767 RefSeq (protein) NP_001004 NP_001308630 NP_001308631 NP_001308633 NP_001308634 NP_001308635 NP_084043 Location (UCSC) Chr 19: 54.2 – 54.25 Mb Chr 7: 3.71 – 3.71 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

40S ribosomal protein S9is aproteinthat in humans is encoded by theRPS9gene.

Ribosomes,theorganellesthatcatalyzeprotein synthesis,consist of asmall 40S subunitand alarge 60S subunit.Together these subunits are composed of 4RNAspecies and approximately 80 structurally distinct proteins. This gene encodes aribosomal proteinthat is a component of the 40S subunit. The protein belongs to the S4P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene incolorectal cancerscompared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, multiple processedpseudogenesderived from this gene are dispersed through the genome.

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins".Biochem. Cell Biol.73(11–12): 933–47.doi:10.1139/o95-101.PMID8722009.
• Mundus DA, Bulygin KN, Yamkovoy VI, et al. (1993). "Structural arrangement of the codon-anticodon interaction area in human placenta ribosomes. Affinity labelling of the 40S subunits by derivatives of oligoribonucleotides containing the AUG codon".Biochim. Biophys. Acta.1173(3): 273–82.doi:10.1016/0167-4781(93)90124-v.PMID8318536.
• Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996)."Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry".Eur. J. Biochem.239(1): 144–9.doi:10.1111/j.1432-1033.1996.0144u.x.PMID8706699.
• Yu Z, Ford BN, Glickman BW (2000)."Identification of genes responsive to BPDE treatment in HeLa cells using cDNA expression assays".Environ. Mol. Mutagen.36(3): 201–5.doi:10.1002/1098-2280(2000)36:3<201::AID-EM3>3.0.CO;2-1.PMID11044901.S2CID19391792.
• Bortoluzzi S, d'Alessi F, Romualdi C, Danieli GA (2002)."Differential expression of genes coding for ribosomal proteins in different human tissues".Bioinformatics.17(12): 1152–7.doi:10.1093/bioinformatics/17.12.1152.PMID11751223.
• Andersen JS, Lyon CE, Fox AH, et al. (2002)."Directed proteomic analysis of the human nucleolus".Curr. Biol.12(1): 1–11.Bibcode:2002CBio...12....1A.doi:10.1016/S0960-9822(01)00650-9.PMID11790298.S2CID14132033.
• Yoshihama M, Uechi T, Asakawa S, et al. (2002)."The human ribosomal protein genes: sequencing and comparative analysis of 73 genes".Genome Res.12(3): 379–90.doi:10.1101/gr.214202.PMC155282.PMID11875025.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
• Dubois T, Zemlickova E, Howell S, Aitken A (2003). "Centaurin-alpha 1 associates in vitro and in vivo with nucleolin".Biochem. Biophys. Res. Commun.301(2): 502–8.doi:10.1016/S0006-291X(02)03010-3.PMID12565890.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36(1): 40–5.doi:10.1038/ng1285.PMID14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics".Nature.433(7021): 77–83.Bibcode:2005Natur.433...77A.doi:10.1038/nature03207.PMID15635413.S2CID4344740.
• Yu Y, Ji H, Doudna JA, Leary JA (2005)."Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes".Protein Sci.14(6): 1438–46.doi:10.1110/ps.041293005.PMC2253395.PMID15883184.
• Tu LC, Yan X, Hood L, Lin B (2007)."Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells".Mol. Cell. Proteomics.6(4): 575–88.doi:10.1074/mcp.M600249-MCP200.PMID17220478.
• Ewing RM, Chu P, Elisma F, et al. (2007)."Large-scale mapping of human protein-protein interactions by mass spectrometry".Mol. Syst. Biol.3(1): 89.doi:10.1038/msb4100134.PMC1847948.PMID17353931.