RTI-352
Appearance
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Names | |
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IUPAC name
Methyl 3α-(4-iodophenyl)tropane-2β-carboxylate
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Systematic IUPAC name
Methyl (1R,2S,3R,5S)-3-(4-iodophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate | |
Other names
RTI-4229-352
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Identifiers | |
3D model (JSmol)
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ChemSpider | |
PubChemCID
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UNII | |
CompTox Dashboard(EPA)
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Properties | |
C16H20INO2 | |
Molar mass | 385.245g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state(at 25 °C [77 °F], 100 kPa).
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RTI-352is aphenyltropanethat is used as aradiolabelingligand for theDAT.[1]
RTI-352 is ageometric isomerofRTI-55(β-CIT).[2]
Based on X-ray crystallography, this compound is in atautomericequilibrium residing mostly on the side of the boat-shaped conformer.
References[edit]
- ^U.S. patent 6,358,492
- ^Zhan, Yougen; Saindane, Amit M.; Scheffel, Ursula; Carroll, F. Ivy; Holmquist, Christopher R.; Kepler, John A.; Taylor, George F.; Kuhar, Michael J. (1997). "RTI-352: A 3α Analogue of RTI-55 as an in vivo dopamine transporter binding ligand".Synapse.25(4): 389–392.doi:10.1002/(SICI)1098-2396(199704)25:4<389::AID-SYN10>3.0.CO;2-Q.PMID9097398.