Recluse spider

Recluse spider; Temporal range:Neogene– Present PreꞒ Ꞓ O S D C P T J K Pg N
	Loxosceles gaucho,Brazil
Scientific classification
Domain:	Eukaryota
Kingdom:	Animalia
Phylum:	Arthropoda
Subphylum:	Chelicerata
Class:	Arachnida
Order:	Araneae
Infraorder:	Araneomorphae
Family:	Sicariidae
Genus:	Loxosceles; Heineken & Lowe, 1832
Type species
	L. rufescens; (Dufour,1820)
Species
	143,see text
Synonyms
	CalheirosiaMello-Leitão,1917; LoxoscellaStrand,1906;

Therecluse spiders(Loxosceles(/lɒkˈsɒsɪliːz/), also known asbrown spiders,fiddle-backs,violin spiders,andreapers,is agenusof spiders that was first described by R. T. Lowe in 1832.^[4]They arevenomous spidersknown for their bite, which sometimes produces a characteristic set of symptoms known asloxoscelism.

Recluse spiders are now identified as members of the familySicariidae,having formerly been placed in their own family, the Loxoscelidae. Although recluse spiders are feared, they are usually not aggressive.^[5]

Relation with other spiders

Sicariidae are of the superfamilyScytodoidea.Other families in the Scytodoidea includeDrymusidae,Scytodidae,andPeriegopidae.

Habitat and appearance

Loxoscelesis distributed nearly worldwide in warmer areas. All have six eyes arranged in three groups of two (dyads) and some are brownish with a darker brown characteristicviolinmarking on thecephalothorax.However, the "violin marking" cannot be used as a reliable way to identify the spider as many unrelated species of spider have similar markings. Recluses are typically about 7–12 mm long.

The most common and most famous species in theUnited Statesis thebrown recluse spider(Loxosceles reclusa). It is found in a large area of the Midwest, west to Colorado and the New Mexico state line and east to northern Georgia. Sporadic records from other locations only represent incidental introductions, not established populations.^[6]The brown recluse feeds on whatever small prey is available, and has been observed to prefer scavenging over actively hunting.^[7]Other notable members of this genus include theChilean recluse spider(L. laeta) and theMediterranean recluse spider(L. rufescens).

Recently, concerns have been raised regarding recluses spreading faster due to warmer air carrying them farther as a result of changing climate. On the contrary, newly hatched recluses do not travel viaballooningand thus the populations are confined to very tight spaces with dense populations.^[8]MostLoxoscelescan live for one and a half to two years. Many species of this genus can live for very long times without food or water. Insecticides often fail to kill the spider, instead intoxicating its nervous system and inducing erratic behavior.^[9]

Identification

This genus is very hard to identify, as they have very simple coloration andmorphology.Many other spiders have similar dorsal markings, leading to confusion and misidentification. They can be most readily distinguished by having 6 eyes, arranged in three pairs. None of the pairs of eyes touch each other, and are arranged in a U shape. The presence of two claws per foot and a rather flatcephalothoraxfurther help distinguish them.^[10]^[11]

Venom components and effects

Loxoscelesspiders, likeHexophthalmaspecies, have potenttissue-destroying venomscontaining the dermonecrotic agentsphingomyelinase D,which is otherwise found only in a few pathogenic bacteria.^[12]Recent research has indicated the venom is composed largely ofsulfated nucleosides,though these compounds are relatively new discoveries, so little is known about them.^[13]The venom of several species is capable of producingnecrotic lesionsthat are slow to heal and may requireskin grafts.Rarely, the venom is carried by thebloodstream,causing red blood cell destruction.

The venom is identical in male and female spiders, but females can have almost twice the concentration of toxins. For unknown reasons, the toxicity of the venom to mammalian species varies; recluse bites may cause necrosis in humans, rabbits, and guinea pigs, but not in mice or rats.^[14]

The Chilean recluse (L. laeta) supposedly has a more potent venom, which results in systemic involvement more often. AllLoxoscelesspecies that have been tested have venoms similar to that of the brown recluse, and all should be avoided. In general, though, they are not aggressive and commonly occupy human dwellings without causing problems.^[15]

Many types of skin wounds are mistaken for or assumed to be the result of a recluse spider bite. Several diseases can mimic the lesions of the bite, includingLyme disease,variousfungalandbacterialinfections, and the first sore ofsyphilis.^[16]It is important to associate the spider directly with the bite to avoid improper treatment, and to successfully treat common infections or other conditions if no spider was seen.

Bites most often occur as a defense when the spider is trapped against the skin, in clothing, for example.^[8]The total volume of venom is minute (only 2 micrograms injected out of 4 microliters in the venom glands).^[17]

The bite of a recluse spider can generally be categorized into one of the following groups:^[8]

Unremarkable – self-healing minute damage
Mild reaction – self-healing damage with itchiness, redness, patterns of aggressive behavior and a mild lesion.
Dermonecrotic – the uncommon, "classic" recluse bite, producing a necrotic skin lesion. About 66% of necrotic bite lesions heal with no complications.^[18]In extreme cases, the lesion may be up to 40 millimeters wide, last for several months, and heal with a permanent scar.^[8]
Systemic or viscerocutaneous – an extremely rare, systemic reaction to envenomation of the bloodstream. It is observed more often in children.^[8]

Most bites are unremarkable or mild.^[19]^[20]^[21]

Species

As of September 2022^[update]it contains 143 species, found in Central America, the Caribbean, Oceania, Asia, Africa, North America, Europe, and South America:^[1]

L. acceptaChamberlin,1920–Peru
L. adelaidaGertsch,1967–Brazil
L. alamosaGertsch & Ennik, 1983–Mexico
L. amazonicaGertsch, 1967– Peru, Brazil
L. anomala(Mello-Leitão,1917)– Brazil
L. apacheaGertsch & Ennik, 1983– USA, Mexico
L. aphrastaWang, 1994–China
L. araneaGertsch, 1973– Mexico
L. arizonicaGertsch & Mulaik, 1940– USA
L. aureaGertsch, 1973– Mexico
L. bajaGertsch & Ennik, 1983– Mexico
L. barbaraGertsch & Ennik, 1983– Mexico
L. belliGertsch, 1973– Mexico
L. bentejuiPlanas & Ribera, 2015– Canary Is.
L. bergeriStrand,1906–Namibia
L. bettyaeGertsch, 1967– Peru
L. blancasiGertsch, 1967– Peru
L. blandaGertsch & Ennik, 1983– USA
L. bonetiGertsch, 1958– Mexico,El Salvador
L. candelaGertsch & Ennik, 1983– Mexico
L. carabobensisGonzález-Sponga, 2010–Venezuela
L. cardosoiBertani,von Schimonsky & Gallão, 2018– Brazil
L. caribbaeaGertsch, 1958–Greater Antilles
L. carinhanhaBertani, von Schimonsky & Gallão, 2018– Brazil
L. carmenaGertsch & Ennik, 1983– Mexico
L. cederbergensisLotz, 2017–South Africa
L. chapadensisBertani, Fukushima & Nagahama, 2010– Brazil
L. chinatecaGertsch & Ennik, 1983– Mexico
L. coheniZamani,Mirshamsi &Marusik,2021– southwestern Iran^[22]
L. colimaGertsch, 1958– Mexico
L. conocochaGertsch, 1967– Peru
L. coquimboGertsch, 1967–Chile
L. corozalensisGonzález-Sponga, 2010– Venezuela
L. coyoteGertsch & Ennik, 1983– Mexico
L. cubanaGertsch, 1958–Cuba,Bahama Is., Hispaniola
L. cubiroensisGonzález-Sponga, 2010– Venezuela
L. curimaguensisGonzález-Sponga, 2010– Venezuela
L. dejageraeLotz, 2017– South Africa
L. desertaGertsch, 1973– USA, Mexico
L. deviaGertsch & Mulaik, 1940– USA, Mexico
L. diaguitaBrescovit,Taucare-Ríos, Magalhaes & Santos, 2017– Chile
L. ericsoniBertani, von Schimonsky & Gallão, 2018– Brazil
L. fontaineiMillot, 1941–Guinea
L. foutadjalloniMillot, 1941– Guinea
L. franciscaGertsch & Ennik, 1983– Mexico
L. frizzelliGertsch, 1967– Peru
L. gauchoGertsch, 1967– Brazil. Introduced to Tunisia
L. gloriaGertsch, 1967–Ecuador,Peru
L. griffinaeLotz, 2017– Namibia
L. guajiraCala-Riquelme, Gutiérrez-Estrada & Flórez, 2015–Colombia
L. guatemalaGertsch, 1973–Guatemala
L. guayotaPlanas & Ribera, 2015– Canary Is.
L. haddadiLotz, 2017– South Africa
L. harrietaeGertsch, 1967– Peru
L. herreriGertsch, 1967– Peru
L. hirsutaMello-Leitão, 1931– Brazil,Paraguay,Argentina
L. huastecaGertsch & Ennik, 1983– Mexico
L. hupalupaPlanas & Ribera, 2015– Canary Is.
L. imazighenRibera & Massa, 2021- Morocco
L. immodesta(Mello-Leitão, 1917)– Brazil
L. incaGertsch, 1967– Peru
L. insulaGertsch & Ennik, 1983– Mexico
L. intermediaMello-Leitão, 1934– Brazil, Argentina
L. irishiLotz, 2017– Namibia
L. jacaGertsch & Ennik, 1983– Mexico
L. jamaicaGertsch & Ennik, 1983–Jamaica
L. jarmilaGertsch & Ennik, 1983– Jamaica
L. juliaGertsch, 1967– Peru
L. kaibaGertsch & Ennik, 1983– USA
L. karsticaBertani, von Schimonsky & Gallão, 2018– Brazil
L. lacroixiMillot, 1941– Ivory Coast
L. lactaWang, 1994– China
L. laeta(Nicolet, 1849)– South America. Introduced to USA,Finland,Australia
L. lawrenceiCaporiacco,1955– Venezuela,Trinidad,Curaçao
L. luteaKeyserling,1877– Colombia, Ecuador
L. luteolaGertsch, 1973– Mexico
L. mahanPlanas & Ribera, 2015– Canary Is.
L. maisiSánchez-Ruiz & Brescovit, 2013– Cuba
L. makapanensisLotz, 2017– South Africa
L. malintziValdez-Mondragón, Cortez-Roldán, Juárez-Sánchez & Solís-Catalán, 2018– Mexico
L. manuelaGertsch & Ennik, 1983– Mexico
L. maraisiLotz, 2017– Namibia
L. marthaGertsch & Ennik, 1983– USA
L. meruensisTullgren,1910–Ethiopia,Kenya,Tanzania
L. mistecaGertsch, 1958– Mexico
L. mogoteSánchez-Ruiz & Brescovit, 2013– Cuba
L. mrazigRibera & Planas, 2009–Tunisia
L. mulegeGertsch & Ennik, 1983– Mexico
L. muriciensisFukushima, de Andrade & Bertani, 2017– Brazil
L. nahuanaGertsch, 1958– Mexico
L. neuvilleiSimon,1909– Ethiopia,Somalia,East Africa
L. niedeguidonaede Andrade, Bertani, Nagahama & Barbosa, 2012– Brazil
L. olivaresiGonzález-Sponga, 2010– Venezuela
L. olmeaGertsch, 1967– Peru
L. pallallaBrescovit, Taucare-Ríos, Magalhaes & Santos, 2017– Chile
L. palmaGertsch & Ennik, 1983– USA, Mexico
L. panamaGertsch, 1958–Panama
L. parramaeNewlands, 1981– South Africa
L. persicaRibera &Zamani,2017–Iran
L. pilosaPurcell,1908– Namibia, South Africa
L. piuraGertsch, 1967– Peru
L. pucaraGertsch, 1967– Peru
L. puortoiMartins, Knysak & Bertani, 2002– Brazil
L. reclusaGertsch & Mulaik, 1940–North America
L. ricaGertsch & Ennik, 1983–Costa Rica
L. rosanaGertsch, 1967– Peru
L. rothiGertsch & Ennik, 1983– Mexico
L. rufescens(Dufour, 1820)(type) –Southern Europe,northern Africa to Iran. Introduced to USA, Mexico, Macaronesia, South Africa,India,China,Japan,Korea,Laos,Thailand,Australia,Hawaii
L. rufipes(Lucas, 1834)– Guatemala, Panama, Colombia. Introduced to West Africa
L. russelliGertsch & Ennik, 1983– USA
L. sabinaGertsch & Ennik, 1983– USA
L. sansebastianensisGonzález-Sponga, 2010– Venezuela
L. seriGertsch & Ennik, 1983– Mexico
L. similisMoenkhaus, 1898– Brazil
L. simillimaLawrence, 1927– Southern Africa
L. smithiSimon, 1897– Ethiopia,Malawi,Kenya, Tanzania
L. sonoraGertsch & Ennik, 1983– Mexico
L. spadiceaSimon, 1907– Peru,Bolivia,Argentina
L. speluncarumSimon, 1893– South Africa
L. spinulosaPurcell, 1904– South Africa
L. surcaGertsch, 1967– Peru, Chile
L. taeniopalpisSimon, 1907– Ecuador
L. tainoGertsch & Ennik, 1983– Bahama Is., Jamaica, Hispaniola
L. tazartePlanas & Ribera, 2015– Canary Is.
L. tehuanaGertsch, 1958– Mexico
L. tenangoGertsch, 1973– Mexico
L. tenochtitlanValdez-Mondragón, 2019– Mexico
L. teresaGertsch & Ennik, 1983– Mexico
L. tibicenaPlanas & Ribera, 2015– Canary Is.
L. tlacolulaGertsch & Ennik, 1983– Mexico
L. tolantongoNavarro-Rodríguez & Valdez-Mondragón, 2020- Mexico
L. troglobiaSouza & Ferreira, 2018– Brazil
L. turanensisZamani et al., 2020– southern Turkmenistan and eastern Iran^[22]
L. valdosaGertsch, 1973– Mexico
L. vallenarBrescovit, Taucare-Ríos, Magalhaes & Santos, 2017– Chile
L. variegataSimon, 1897– Paraguay
L. vicenteiTaucare-Ríos, Brescovit & Villablanca, 2022- Chile
L. virgoGertsch & Ennik, 1983– Virgin Is.
L. vonwredeiNewlands, 1980– Namibia
L. weyrauchiGertsch, 1967– Peru
L. willianilsoniFukushima, de Andrade & Bertani, 2017– Brazil
L. yucatanaChamberlin &Ivie,1938– Mexico,Belize,Guatemala
L. zapotecaGertsch, 1958– Mexico

References

^^a ^b ^cGloor, Daniel; Nentwig, Wolfgang; Blick, Theo; Kropf, Christian (2019)."Gen. Loxosceles Heineken & Lowe, 1832".World Spider Catalog Version 20.0.Natural History Museum Bern.doi:10.24436/2.Retrieved2019-08-26.
^Brignoli, P. M. (1978). "Spinnen aus Brasilien, II. Vier neue Ochyroceratidae aus Amazonas nebst Bemerkungen über andere Amerikanische Arten (Arachnida: Araneae)".Studies on Neotropical Fauna and Environment.13:18.doi:10.1080/01650527809360529.
^Gertsch, W. J.; Ennik, F. (1983). "The spider genusLoxoscelesin North America, Central America, and the West Indies (Araneae, Loxoscelidae) ".Bulletin of the American Museum of Natural History.175:277.
^Lowe, R. T. (1832). "Descriptions of two species of Araneidae, natives of Madeira".The Zoological Journal.5:320–323.
^Binkovitz, Leah."Why We Should All Celebrate Save a Spider Day".Smithsonian.Retrieved2017-07-17.
^Vetter, Rick."Myth of the Brown Recluse: Fact, Fear, and Loathing".RetrievedOctober 26,2022.
^Sandidge, J. (2003)."Arachnology: Scavenging by brown recluse spiders".Nature.426(30): 30.Bibcode:2003Natur.426...30S.doi:10.1038/426030a.PMID 14603305.S2CID 4394140.
^^a ^b ^c ^d ^eVetter, R.S. (2008)."Spiders of the genusLoxosceles:A review of biological, medical, and psychological aspects regarding envenomations "(PDF).Journal of Arachnology.36(3): 150–163.doi:10.1636/RSt08-06.1.S2CID 7746032.
^Hite, J. M. (1966).The biology of the brown recluse spider.Kansas State University.{{cite book}}:CS1 maint: location missing publisher (link)
^"Genus Loxosceles - Brown Spiders".bugguide.net.Retrieved2022-09-05.
^Chaim, Olga Meiri; Trevisan-Silva, Dilza; Chaves-Moreira, Daniele; Wille, Ana Carolina M.; Ferrer, Valéria Pereira; Matsubara, Fernando Hitomi; Mangili, Oldemir Carlos; da Silveira, Rafael Bertoni; Gremski, Luiza Helena; Gremski, Waldemiro; Senff-Ribeiro, Andrea; Veiga, Silvio Sanches (2011-03-22)."Brown Spider (Loxoscelesgenus) venom toxins: Tools for biological purposes ".Toxins.3(3): 309–344.doi:10.3390/toxins3030309.ISSN 2072-6651.PMC3202818.PMID 22069711.
^Binford, G.J.; et al. (2005)."Sphingomyelinase D from venoms ofLoxoscelesspiders: evolutionary insights from cDNA sequences and gene structure "(PDF).Toxicon.45(5): 547–560.doi:10.1016/j.toxicon.2004.11.011.PMID 15777950.
^Schroeder, F.C.; et al. (2008)."NMR-spectroscopic screening of spider venom reveals sulfated nucleosides as major components for the brown recluse and related species".PNAS.105(38): 14283–14287.Bibcode:2008PNAS..10514283S.doi:10.1073/pnas.0806840105.PMC2567178.PMID 18794518.
^Swanson, D.L.; Vetter, R.S. (2006)."Loxoscelism"(PDF).Clinics in Dermatology.24(3): 213–221.doi:10.1016/j.clindermatol.2005.11.006.PMID 16714202.Retrieved12 April2011.
^Vetter, R.; Barger, D. (2002)."An infestation of 2,055 brown recluse spiders (Araneae: Sicariidae) and no envenomations in a Kansas home: implications for bite diagnoses in nonendemic areas".J Med Entomol.39(6): 948–951.doi:10.1603/0022-2585-39.6.948.PMID 12495200.
^Vetter, R.; Bush, S. (2002). "The diagnosis of brown recluse spider bite is overused for dermonecrotic wounds of uncertain etiology".Annals of Emergency Medicine.39(5): 544–546.doi:10.1067/mem.2002.123594.PMID 11973562.
^Barceloux, Donald G. (2008-11-12).Medical Toxicology of Natural Substances: Foods, fungi, medicinal herbs, plants, and venomous animals.John Wiley & Sons.ISBN 978-0-471-72761-3.
^Pauli, I.; et al. (2006). "The efficacy of antivenom in loxoscelism treatment".Toxicon.48(2): 123–137.doi:10.1016/j.toxicon.2006.05.005.PMID 16808942.
^Wright, S.W.; et al. (1997). "Clinical presentation and outcome of brown recluse spider bite".Annals of Emergency Medicine.30(1): 28–32.doi:10.1016/S0196-0644(97)70106-9.PMID 9209221.
^Anderson, P.C. (1998). "Missouri brown recluse spider: A review and update".Missouri Medicine.95(7): 318–22.PMID 9666677.
^Cacy, J.; Mold, J.W. (1999). "The clinical characteristics of brown recluse spider bites treated by family physicians: An OKPRN study".Journal of Family Practice.48(7): 536–542.PMID 10428252.
^^a ^bAlireza Zamani, Omid Mirshamsi, Yuri M Marusik. 2021. ‘Burning Violin’: The Medically Important Spider GenusLoxosceles(Araneae: Sicariidae) in Iran, Turkmenistan, and Afghanistan, With Two New Species.Journal of Medical Entomology,tjaa257,https://doi.org/10.1093/jme/tjaa257,Published: 10 December 2020.

External links

[WSC_g3087-1] Gloor, Daniel; Nentwig, Wolfgang; Blick, Theo; Kropf, Christian (2019)."Gen. Loxosceles Heineken & Lowe, 1832".World Spider Catalog Version 20.0.Natural History Museum Bern.doi:10.24436/2.Retrieved2019-08-26.

[Brig1978-2] Brignoli, P. M. (1978). "Spinnen aus Brasilien, II. Vier neue Ochyroceratidae aus Amazonas nebst Bemerkungen über andere Amerikanische Arten (Arachnida: Araneae)".Studies on Neotropical Fauna and Environment.13:18.doi:10.1080/01650527809360529.

[Gert1983-3] Gertsch, W. J.; Ennik, F. (1983). "The spider genusLoxoscelesin North America, Central America, and the West Indies (Araneae, Loxoscelidae) ".Bulletin of the American Museum of Natural History.175:277.

[Lowe1832-4] Lowe, R. T. (1832). "Descriptions of two species of Araneidae, natives of Madeira".The Zoological Journal.5:320–323.

[5] Binkovitz, Leah."Why We Should All Celebrate Save a Spider Day".Smithsonian.Retrieved2017-07-17.

[VetterMyth-6] Vetter, Rick."Myth of the Brown Recluse: Fact, Fear, and Loathing".RetrievedOctober 26,2022.

[Arachnology2003-Sandidge-7] Sandidge, J. (2003)."Arachnology: Scavenging by brown recluse spiders".Nature.426(30): 30.Bibcode:2003Natur.426...30S.doi:10.1038/426030a.PMID 14603305.S2CID 4394140.

[vetter-8] Vetter, R.S. (2008)."Spiders of the genusLoxosceles:A review of biological, medical, and psychological aspects regarding envenomations "(PDF).Journal of Arachnology.36(3): 150–163.doi:10.1636/RSt08-06.1.S2CID 7746032.

[Hite-9] Hite, J. M. (1966).The biology of the brown recluse spider.Kansas State University.{{cite book}}:CS1 maint: location missing publisher (link)

[10] "Genus Loxosceles - Brown Spiders".bugguide.net.Retrieved2022-09-05.

[11] Chaim, Olga Meiri; Trevisan-Silva, Dilza; Chaves-Moreira, Daniele; Wille, Ana Carolina M.; Ferrer, Valéria Pereira; Matsubara, Fernando Hitomi; Mangili, Oldemir Carlos; da Silveira, Rafael Bertoni; Gremski, Luiza Helena; Gremski, Waldemiro; Senff-Ribeiro, Andrea; Veiga, Silvio Sanches (2011-03-22)."Brown Spider (Loxoscelesgenus) venom toxins: Tools for biological purposes ".Toxins.3(3): 309–344.doi:10.3390/toxins3030309.ISSN 2072-6651.PMC3202818.PMID 22069711.

[binford-12] Binford, G.J.; et al. (2005)."Sphingomyelinase D from venoms ofLoxoscelesspiders: evolutionary insights from cDNA sequences and gene structure "(PDF).Toxicon.45(5): 547–560.doi:10.1016/j.toxicon.2004.11.011.PMID 15777950.

[schroeder-13] Schroeder, F.C.; et al. (2008)."NMR-spectroscopic screening of spider venom reveals sulfated nucleosides as major components for the brown recluse and related species".PNAS.105(38): 14283–14287.Bibcode:2008PNAS..10514283S.doi:10.1073/pnas.0806840105.PMC2567178.PMID 18794518.

[Swanson-Vetter-14] Swanson, D.L.; Vetter, R.S. (2006)."Loxoscelism"(PDF).Clinics in Dermatology.24(3): 213–221.doi:10.1016/j.clindermatol.2005.11.006.PMID 16714202.Retrieved12 April2011.

[JMedEntomol2002-Vetter-15] Vetter, R.; Barger, D. (2002)."An infestation of 2,055 brown recluse spiders (Araneae: Sicariidae) and no envenomations in a Kansas home: implications for bite diagnoses in nonendemic areas".J Med Entomol.39(6): 948–951.doi:10.1603/0022-2585-39.6.948.PMID 12495200.

[annemergmed2002-Vetter-16] Vetter, R.; Bush, S. (2002). "The diagnosis of brown recluse spider bite is overused for dermonecrotic wounds of uncertain etiology".Annals of Emergency Medicine.39(5): 544–546.doi:10.1067/mem.2002.123594.PMID 11973562.

[17] Barceloux, Donald G. (2008-11-12).Medical Toxicology of Natural Substances: Foods, fungi, medicinal herbs, plants, and venomous animals.John Wiley & Sons.ISBN 978-0-471-72761-3.

[pauli-18] Pauli, I.; et al. (2006). "The efficacy of antivenom in loxoscelism treatment".Toxicon.48(2): 123–137.doi:10.1016/j.toxicon.2006.05.005.PMID 16808942.

[wright-19] Wright, S.W.; et al. (1997). "Clinical presentation and outcome of brown recluse spider bite".Annals of Emergency Medicine.30(1): 28–32.doi:10.1016/S0196-0644(97)70106-9.PMID 9209221.

[anderson-20] Anderson, P.C. (1998). "Missouri brown recluse spider: A review and update".Missouri Medicine.95(7): 318–22.PMID 9666677.

[cacy-21] Cacy, J.; Mold, J.W. (1999). "The clinical characteristics of brown recluse spider bites treated by family physicians: An OKPRN study".Journal of Family Practice.48(7): 536–542.PMID 10428252.

[Zamanietal2020-22] Alireza Zamani, Omid Mirshamsi, Yuri M Marusik. 2021. ‘Burning Violin’: The Medically Important Spider GenusLoxosceles(Araneae: Sicariidae) in Iran, Turkmenistan, and Afghanistan, With Two New Species.Journal of Medical Entomology,tjaa257,https://doi.org/10.1093/jme/tjaa257,Published: 10 December 2020.

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