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Nuclear receptors that bind to retinoids
Retinoid receptors arenuclear receptors (a class ofproteins ) that bind toretinoids .When bound to a retinoid, they act astranscription factors ,altering theexpression of genes with corresponding response elements. Significant age-related declines in the levels of retinoid receptors in theforebrains of rats have been reversed by supplementation with theomega-3 fatty acids eicosapentaenoic acid (EPA) anddocosahexaenoic acid (DHA), which can restoreneurogenesis .[1]
Subtypes include:
References [ edit ]
^ Dyall SC, Michael GJ, Michael-Titus AT (2010). "Omega-3 fatty acids reverse age-related decreases in nuclear receptors and increase neurogenesis in old rats".Journal of Neuroscience Research .88 (10): 2091–2102.doi :10.1002/jnr.22390 .PMID 20336774 .S2CID 1620277 .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4)β-Scaffold factors with minor groove contacts
(0) Other transcription factors
RAR Tooltip Retinoic acid receptor
Retinoic acid metabolism inhibitors: Liarozole RXR Tooltip Retinoid X receptor
