Rnd2
Appearance
Rnd2is a small (~21 kDa) signalingG protein(to be specific, aGTPase), and is a member of theRndsubgroup of theRho family of GTPases.[5]It is encoded by the geneRND2.[6]
Function
[edit]It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998).[supplied by OMIM][7]
This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking.
Clinical significance
[edit]The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility geneBRCA1.[6]
Interactions
[edit]Rnd2 has been shown tointeractwith:
References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000108830–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000001313–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Ridley AJ (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking".Trends Cell Biol.16(10): 522–9.doi:10.1016/j.tcb.2006.08.006.ISSN0962-8924.PMID16949823.
- ^ab"Entrez Gene: RND2 Rho family GTPase 2".
- ^"Entrez Gene: RND1 Rho family GTPase 1".
- ^Wennerberg K, Forget MA, Ellerbroek SM, Arthur WT, Burridge K, Settleman J, Der CJ, Hansen SH (Jul 2003)."Rnd proteins function as RhoA antagonists by activating p190 RhoGAP".Curr. Biol.13(13): 1106–15.Bibcode:2003CBio...13.1106W.doi:10.1016/s0960-9822(03)00418-4.PMC6918695.PMID12842009.
- ^Naud N, Touré A, Liu J, Pineau C, Morin L, Dorseuil O, Escalier D, Chardin P, Gacon G (May 2003)."Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells".Biochem. J.372(Pt 1): 105–12.doi:10.1042/BJ20021652.PMC1223378.PMID12590651.
- ^Katoh H, Harada A, Mori K, Negishi M (May 2002)."Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers".Mol. Cell. Biol.22(9): 2952–64.doi:10.1128/mcb.22.9.2952-2964.2002.PMC133765.PMID11940653.
Further reading
[edit]- Chardin P (1991). "Small GTP-binding proteins of the ras family: a conserved functional mechanism?".Cancer Cells.3(4): 117–26.PMID1909153.
- Bonaldo MF, Lennon G, Soares MB (1997)."Normalization and subtraction: two approaches to facilitate gene discovery".Genome Res.6(9): 791–806.doi:10.1101/gr.6.9.791.PMID8889548.
- Smith TM, Lee MK, Szabo CI, Jerome N, McEuen M, Taylor M, Hood L, King MC (1997)."Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1".Genome Res.6(11): 1029–49.doi:10.1101/gr.6.11.1029.PMID8938427.
- Nobes CD, Lauritzen I, Mattei MG, Paris S, Hall A, Chardin P (1998)."A New Member of the Rho Family, Rnd1, Promotes Disassembly of Actin Filament Structures and Loss of Cell Adhesion".J. Cell Biol.141(1): 187–97.doi:10.1083/jcb.141.1.187.PMC2132722.PMID9531558.
- Tanaka H, Fujita H, Katoh H, Mori K, Negishi M (2002)."Vps4-A (vacuolar protein sorting 4-A) is a binding partner for a novel Rho family GTPase, Rnd2".Biochem. J.365(Pt 2): 349–53.doi:10.1042/BJ20020062.PMC1222680.PMID11931639.
- Katoh H, Harada A, Mori K, Negishi M (2002)."Socius Is a Novel Rnd GTPase-Interacting Protein Involved in Disassembly of Actin Stress Fibers".Mol. Cell. Biol.22(9): 2952–64.doi:10.1128/MCB.22.9.2952-2964.2002.PMC133765.PMID11940653.
- Fujita H, Katoh H, Ishikawa Y, Mori K, Negishi M (2003)."Rapostlin is a novel effector of Rnd2 GTPase inducing neurite branching".J. Biol. Chem.277(47): 45428–34.doi:10.1074/jbc.M208090200.PMID12244061.
- Naud N, Touré A, Liu J, Pineau C, Morin L, Dorseuil O, Escalier D, Chardin P, Gacon G (2003)."Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells".Biochem. J.372(Pt 1): 105–12.doi:10.1042/BJ20021652.PMC1223378.PMID12590651.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J,Zoghbi HY,Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network".Nature.437(7062): 1173–8.Bibcode:2005Natur.437.1173R.doi:10.1038/nature04209.PMID16189514.S2CID4427026.
- Kim YS, Hori M, Yasuda K, Ozaki H (2006). "Differences in the gestational pattern of mRNA expression of the Rnd family in rat and human myometria".Comp. Biochem. Physiol. A.142(4): 410–5.doi:10.1016/j.cbpa.2005.08.028.PMID16311049.
- Tanaka H, Katoh H, Negishi M (2006)."Pragmin, a novel effector of Rnd2 GTPase, stimulates RhoA activity".J. Biol. Chem.281(15): 10355–64.doi:10.1074/jbc.M511314200.PMID16481321.