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Ryszard Gryglewski

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Ryszard Jerzy Gryglewski
Born(1932-08-04)4 August 1932
Wilno,Poland(now Vilnius, Lithuania)
Died30 January 2023(2023-01-30)(aged 90)
Kraków,Poland
NationalityPolish
CitizenshipPolish
Alma materJagiellonian University
Known forDiscovery ofprostacyclin
AwardsPrize of the Foundation for Polish Science(1997)
Sir Hans Krebs Medal(2004)
Scientific career
FieldsPharmacology,medicine

Ryszard Jerzy Gryglewski(Polish:[ˈrɨʂard ˈjɛʐɨ ˈɡrɨɡlɛfskʲi];4 August 1932 – 30 January 2023) was a Polishpharmacologistandphysician.He is known for co-discoveringprostacyclin.He was a Member of thePolish Academy of Learning(PAU)[1]and thePolish Academy of Sciences(PAN).[2]He was the recipient ofSir Hans Krebs Medalas well as Poland's highest order of merit, theOrder of the White Eagle.

Life and career

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Gryglewski graduated in medicine from theJagiellonian UniversityinKraków,where he also wrote his doctorate inPharmacologyand in 1971 became a professor. In 1965, he was appointed as the head of the Department of Pharmacology at the Medical Academy in Kraków.[3]He was a member of many pharmacological associations around the world and since 1993 president of the Jagiellonian Medical Research Centre (Jagiellońskie Centrum Badań Medycznych).

His scientific work concerned experimental pharmacology. His research focused on the contribution of the blood-vascular system in building up immunity againstthrombosisin the development ofsclerosis.In 1976, together with S. Bunting, J. Vane and S. Moncada, he discoveredprostacyclin,which set off many further scientific discoveries.[4]

In 1975, he showed that the inhibition of the release ofarachidonic acidrepresents the mechanisms of action ofglucocorticosteroids.7 His study describing discovery of the free radical mediated mechanism underlying the regulation of nitric oxide stability was published inNaturein 1986.[5]

Together withAndrzej Szczeklik,he was involved in the research on the so-called “aspirin-induced asthma”(AIA) and contributed to the concept that this disease is not caused by sensitization to nonsteroidalanti-inflammatory drugsbut results from the inhibition of thecyclooxygenasetype 1 (COX-1) pathway.[6]

Among his other notable discoveries was the fact thatantiplatelet drugs,such asClopidogrel,exert a strongfibrynoliticeffect in the mechanism depentent on theendothelial cells.[7]

Gryglewski died inKrakówon 30 January 2023, at the age of 90.[8]

Awards and honours

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In 1997, he was awarded thePrize of the Foundation for Polish Sciencefor a series of studies on the regulation of thromboresistance.[9]

In 2002, he received the Grand Cross of theOrder of Polonia Restitutafrom PresidentAleksander Kwaśniewskifor "outsanding merits in his scientific and didactical work".[10]

In 2004, he receivedSir Hans Krebs Medalof theFederation of European Biochemical Societies(FEBS).[11]

On 20 January 2017, he was awarded Poland's highest decoration, theOrder of the White Eagle,by PresidentAndrzej Dudafor his "distinguished contributions to the development of pharmacology and clinical medicine".[12][13]

See also

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References

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  1. ^MEMBERS OF POLISH ACADEMY OF ARTS AND SCIENCES, PAU CLASS V OF MEDICINE, Full Members,Archived14 October 2014 at theWayback MachinePolish Academy of Learning.Accessed 28 January 2010
  2. ^Full Members - Division VI,[permanent dead link]Polish Academy of Sciences.Accessed 27 January 2010
  3. ^Jacek Jawień, Janusz Marcinkiewicz (27 February 2023)."Professor Ryszard Jerzy Gryglewski (1932–2023): in memoriam".mp.pl.Retrieved3 November2023.
  4. ^Jacek Jawień and Janusz Marcinkiewicz (27 February 2023)."Professor Ryszard Jerzy Gryglewski (1932–2023): in memoriam".mp.pl.Retrieved14 May2023.
  5. ^Jacek Jawień, Janusz Marcinkiewicz (27 February 2023)."Professor Ryszard Jerzy Gryglewski (1932–2023): in memoriam".mp.pl.Retrieved3 November2023.
  6. ^Jacek Jawień, Janusz Marcinkiewicz (27 February 2023)."Professor Ryszard Jerzy Gryglewski (1932–2023): in memoriam".mp.pl.Retrieved3 November2023.
  7. ^Gryglewski J, Dupin J, Uracz W, Swies J, Hou G, Gravier D, Casadebaig F (2000). "Thrombolysis by thienopyridines and their congeners".Journal of Physiology and Pharmacology:683–693.PMID11192941.
  8. ^"Nie żyje prof. Ryszard Gryglewski, wybitny uczony, autor przełomowych odkryć w dziedzinie farmakologii".www.cm-uj.krakow.pl(in Polish).Retrieved11 January2024.
  9. ^"Prof. Dr hab. Med. Ryszard Gryglewski - lauret Nagrody FNP 1997".fnp.org.pl(in Polish).Retrieved8 November2023.
  10. ^"M.P. 2002 nr 50 poz. 722".isap.sejm.gov.pl(in Polish).Retrieved8 November2023.
  11. ^"Sir Hans Krebs Medal to Harald Stenmark".ous-research.no.Retrieved8 November2023.
  12. ^"M.P. 2017 poz. 108".isap.sejm.gov.pl(in Polish).Retrieved3 November2023.
  13. ^"Order Orła Białego dla prof. Ryszarda Jerzego Gryglewskiego".prezydent.pl(in Polish). 26 January 2017.Retrieved3 November2023.

Sources

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