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S-14,506

From Wikipedia, the free encyclopedia
S-14,506
Names
Preferred IUPAC name
4-Fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
UNII
  • InChI=1S/C24H26FN3O2/c1-30-21-10-7-18-3-2-4-23(22(18)17-21)28-15-13-27(14-16-28)12-11-26-24(29)19-5-8-20(25)9-6-19/h2-10,17H,11-16H2,1H3,(H,26,29)
    Key: IFMQODYDAUKKEN-UHFFFAOYSA-N
  • InChI=1/C24H26FN3O2/c1-30-21-10-7-18-3-2-4-23(22(18)17-21)28-15-13-27(14-16-28)12-11-26-24(29)19-5-8-20(25)9-6-19/h2-10,17H,11-16H2,1H3,(H,26,29)
    Key: IFMQODYDAUKKEN-UHFFFAOYAH
  • COC1=CC2=C(C=CC=C2N3CCN(CC3)CCNC(=O)C4=CC=C(C=C4)F)C=C1
Properties
C24H26FN3O2
Molar mass 407.489g·mol−1
Except where otherwise noted, data are given for materials in theirstandard state(at 25 °C [77 °F], 100 kPa).

S-14,506is anaphthylpiperazine,a5-HT1A receptoragonist,[1]and adopamine receptorantagonist.[2]

References[edit]

  1. ^Milligan, G.; Kellett, E.; Dacquet, C.; Dubreuil, V.; Jacoby, E.; Millan, M. J.; Lavielle, G.; Spedding, M. (2001). "S 14506: Novel receptor coupling at 5-HT(1A) receptors".Neuropharmacology.40(3): 334–344.doi:10.1016/s0028-3908(00)00162-3.PMID11166326.S2CID36060096.
  2. ^Protais, P.; Chagraoui, A.; Arbaoui, J.; Mocaër, E. (1994). "Dopamine receptor antagonist properties of S 14506, 8-OH-DPAT, raclopride and clozapine in rodents".European Journal of Pharmacology.271(1): 167–177.doi:10.1016/0014-2999(94)90277-1.PMID7698199.