S1PR3

S1PR3
Identifiers
Aliases	S1PR3,EDG-3, EDG3, LPB3, S1P3, sphingosine-1-phosphate receptor 3
External IDs	OMIM:601965;MGI:1339365;HomoloGene:3829;GeneCards:S1PR3;OMA:S1PR3 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9q22.1 Start 88,990,863bp End 89,005,155bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 A5 Start 51,562,675bp End 51,576,833bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in myocardium of left ventricle decidua cardiac muscle tissue of right atrium ventricular zone right ventricle right coronary artery left coronary artery tail of epididymis Descending thoracic aorta superficial temporal artery Top expressed in internal carotid artery molar left lung lobe external carotid artery dermis epithelium of lens fossa body of femur lumbar spinal ganglion abdominal wall More reference expression data BioGPS n/a
Gene ontology Molecular function signal transducer activity lipid binding integrin binding sphingosine-1-phosphate receptor activity G protein-coupled receptor activity protein binding Cellular component integral component of membrane integral component of plasma membrane membrane plasma membrane Biological process Notch signaling pathway signal transduction anatomical structure morphogenesis positive regulation of cytosolic calcium ion concentration G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway negative regulation of establishment of endothelial barrier positive regulation of cell population proliferation sphingosine-1-phosphate receptor signaling pathway regulation of interleukin-1 beta production cytokine production inflammatory response Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 1903 13610 Ensembl ENSG00000213694 ENSMUSG00000067586 UniProt Q99500 Q9Z0U9 RefSeq (mRNA) NM_005226 NM_010101 RefSeq (protein) NP_005217 NP_034231 Location (UCSC) Chr 9: 88.99 – 89.01 Mb Chr 13: 51.56 – 51.58 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

Sphingosine-1-phosphate receptor 3also known asS1PR3is a humangenewhich encodes aG protein-coupled receptorwhich binds the lipid signaling moleculesphingosine 1-phosphate(S1P). Hence this receptor is also known asS1P₃.

Function

This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function.

Evolution

Paraloguesto S1PR3Gene

• S1PR1
• S1PR5
• S1PR2
• S1PR4
• LPAR1
• LPAR3
• LPAR2
• CNR1
• MC5R
• GPR6
• GPR12
• MC4R
• CNR2
• GPR3
• MC3R
• MC2R
• GPR119
• MC1R

See also

• Lysophospholipid receptor

Further reading

• Hla T, Lee MJ, Ancellin N, et al. (2000). "Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors".Ann. N. Y. Acad. Sci.905(1): 16–24.Bibcode:2000NYASA.905...16H.doi:10.1111/j.1749-6632.2000.tb06534.x.PMID10818438.S2CID19435541.
• Spiegel S (2000). "Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors".Ann. N. Y. Acad. Sci.905(1): 54–60.Bibcode:2000NYASA.905...54S.doi:10.1111/j.1749-6632.2000.tb06537.x.PMID10818441.S2CID9257870.
• Watsky MA, Griffith M, Wang DA, Tigyi GJ (2000). "Phospholipid growth factors and corneal wound healing".Ann. N. Y. Acad. Sci.905(1): 142–58.Bibcode:2000NYASA.905..142W.doi:10.1111/j.1749-6632.2000.tb06546.x.PMID10818450.S2CID9789496.
• Takuwa Y (2002). "[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]".Tanpakushitsu Kakusan Koso.47(4 Suppl): 496–502.PMID11915348.
• Van Koppen CJ, Meyer Zu Heringdorf D, Zhang C, et al. (1996). "A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophils".Mol. Pharmacol.49(6): 956–61.PMID8649355.
• Yamaguchi F, Tokuda M, Hatase O, Brenner S (1996). "Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9".Biochem. Biophys. Res. Commun.227(2): 608–14.doi:10.1006/bbrc.1996.1553.PMID8878560.
• An S, Bleu T, Huang W, et al. (1998)."Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids".FEBS Lett.417(3): 279–82.doi:10.1016/S0014-5793(97)01301-X.PMID9409733.S2CID26300053.
• Van Brocklyn JR, Tu Z, Edsall LC, et al. (1999)."Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218".J. Biol. Chem.274(8): 4626–32.doi:10.1074/jbc.274.8.4626.PMID9988698.
• Zhang Q, Peyruchaud O, French KJ, et al. (1999). "Sphingosine 1-phosphate stimulates fibronectin matrix assembly through a Rho-dependent signal pathway".Blood.93(9): 2984–90.doi:10.1182/blood.V93.9.2984.PMID10216094.
• Ancellin N, Hla T (1999)."Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5".J. Biol. Chem.274(27): 18997–9002.doi:10.1074/jbc.274.27.18997.PMID10383399.
• Windh RT, Lee MJ, Hla T, et al. (1999)."Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins".J. Biol. Chem.274(39): 27351–8.doi:10.1074/jbc.274.39.27351.PMID10488065.
• Goetzl EJ, Dolezalova H, Kong Y, et al. (1999). "Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer".Cancer Res.59(20): 5370–5.PMID10537322.
• Lee MJ, Thangada S, Claffey KP, et al. (1999)."Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate".Cell.99(3): 301–12.doi:10.1016/S0092-8674(00)81661-X.PMID10555146.S2CID1126846.
• An S, Zheng Y, Bleu T (2000)."Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5".J. Biol. Chem.275(1): 288–96.doi:10.1074/jbc.275.1.288.PMID10617617.
• Orlati S, Porcelli AM, Hrelia S, et al. (2000). "Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor".Arch. Biochem. Biophys.375(1): 69–77.doi:10.1006/abbi.1999.1589.PMID10683250.
• Lee H, Goetzl EJ, An S (2000). "Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing".Am. J. Physiol., Cell Physiol.278(3): C612–8.doi:10.1152/ajpcell.2000.278.3.C612.PMID10712250.S2CID10976499.
• Kimura T, Watanabe T, Sato K, et al. (2000)."Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3".Biochem. J.348(1): 71–6.doi:10.1042/0264-6021:3480071.PMC1221037.PMID10794715.

External links

• "Lysophospholipid Receptors: S₁P₃".IUPHAR Database of Receptors and Ion Channels.International Union of Basic and Clinical Pharmacology. Archived fromthe originalon 2016-03-03.Retrieved2008-12-05.
• Lysophospholipid+receptorsat the U.S. National Library of MedicineMedical Subject Headings(MeSH)

This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.