SIRPG
Signal-regulatory protein gammais aproteinthat in humans is encoded by theSIRPGgene.[5][6][7]SIRPG has also recently been designatedCD172G(cluster of differentiation172G).
The protein encoded by this gene is a member of thesignal-regulatory protein(SIRP) family, and also belongs to theimmunoglobulin superfamily.SIRP family members arereceptor-type transmembrane glycoproteinsknown to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described.[7]
References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000089012–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000037902–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Ichigotani Y, Matsuda S, Machida K, Oshima K, Iwamoto T, Yamaki K, Hayakawa T, Hamaguchi M (Jan 2001)."Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family".J Hum Genet.45(6): 378–82.doi:10.1007/s100380070013.PMID11185750.
- ^van den Berg TK, van Beek EM, Buhring HJ, Colonna M, Hamaguchi M, Howard CJ, Kasuga M, Liu Y, Matozaki T, Neel BG, Parkos CA, Sano S, Vignery A, Vivier E, Wright M, Zawatzky R, Barclay AN (Dec 2005)."A nomenclature for signal regulatory protein family members".J Immunol.175(12): 7788–9.doi:10.4049/jimmunol.175.12.7788.PMID16339511.
- ^ab"Entrez Gene: SIRPG signal-regulatory protein gamma".
Further reading
[edit]- Kharitonenkov A, Chen Z, Sures I, et al. (1997). "A family of proteins that inhibit signalling through tyrosine kinase receptors".Nature.386(6621): 181–6.Bibcode:1997Natur.386..181K.doi:10.1038/386181a0.PMID9062191.S2CID4259314.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002)."The DNA sequence and comparative analysis of human chromosome 20".Nature.414(6866): 865–71.Bibcode:2001Natur.414..865D.doi:10.1038/414865a.PMID11780052.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
- Brooke G, Holbrook JD, Brown MH, Barclay AN (2004)."Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family".J. Immunol.173(4): 2562–70.doi:10.4049/jimmunol.173.4.2562.PMID15294972.
- Piccio L, Vermi W, Boles KS, et al. (2006)."Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation".Blood.105(6): 2421–7.doi:10.1182/blood-2004-07-2823.PMID15383453.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006)."Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes".Genome Res.16(1): 55–65.doi:10.1101/gr.4039406.PMC1356129.PMID16344560.
External links
[edit]- PDBe-KBprovides an overview of all the structure information available in the PDB for Human Signal-regulatory protein gamma (SIRPG)
This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.
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