Choline transporter-like protein 4

SLC44A4
Identifiers
Aliases	SLC44A4,C6orf29, CTL4, NG22, TPPT, solute carrier family 44 member 4, DFNA72, hTPPT1
External IDs	OMIM:606107;MGI:1917379;HomoloGene:11359;GeneCards:SLC44A4;OMA:SLC44A4 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	31,879,046bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	35,149,412bp
RNA expressionpattern
	Top expressed in
	mucosa of transverse colon; ; right uterine tube; ; rectum; ; duodenum; ; olfactory zone of nasal mucosa; ; gallbladder; ; prostate; ; islet of Langerhans; ; human kidney; ; appendix;
	Top expressed in
	left colon; ; epithelium of stomach; ; ileum; ; intestinal villus; ; Ileal epithelium; ; mucous cell of stomach; ; right kidney; ; pyloric antrum; ; jejunum; ; proximal tubule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	choline transmembrane transporter activity; thiamine pyrophosphate transmembrane transporter activity;
Cellular component	extracellular exosome; membrane; integral component of membrane; plasma membrane; apical plasma membrane;
Biological process	acetylcholine secretion; phosphatidylcholine biosynthetic process; transmembrane transport; acetylcholine biosynthetic process; positive regulation of cell growth; choline transport; thiamine pyrophosphate transmembrane transport; otolith formation; neuromast hair cell development;
	Sources:Amigo/QuickGO
Orthologs
	80736
	70129
ENSG00000232180; ENSG00000204385; ENSG00000231479; ENSG00000228263; ENSG00000206378;
	ENSG00000235336; ENSG00000229077; ENSG00000203463
	ENSMUSG00000007034
	Q53GD3
	Q91VA1
	NM_025257; NM_001178044; NM_001178045
	NM_023557
	NP_001171515; NP_001171516; NP_079533
	NP_076046
	Wikidata
View/Edit Human	View/Edit Mouse

Choline transporter-like protein 4is aproteinthat in humans is encoded by theSLC44A4gene.^[5]^[6]^[7]

References

^^a ^b ^cENSG00000204385, ENSG00000231479, ENSG00000228263, ENSG00000206378, ENSG00000235336, ENSG00000229077, ENSG00000203463 GRCh38: Ensembl release 89: ENSG00000232180, ENSG00000204385, ENSG00000231479, ENSG00000228263, ENSG00000206378, ENSG00000235336, ENSG00000229077, ENSG00000203463–Ensembl,May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000007034–Ensembl,May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^O'Regan S, Traiffort E, Ruat M, Cha N, Compaore D, Meunier FM (Mar 2000)."An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins".Proc Natl Acad Sci U S A.97(4): 1835–40.Bibcode:2000PNAS...97.1835O.doi:10.1073/pnas.030339697.PMC26522.PMID 10677542.
^Traiffort E, Ruat M, O'Regan S, Meunier FM (Feb 2005)."Molecular characterization of the family of choline transporter-like proteins and their splice variants".J Neurochem.92(5): 1116–25.doi:10.1111/j.1471-4159.2004.02962.x.PMID 15715662.S2CID 30921826.
^"Entrez Gene: SLC44A4 solute carrier family 44, member 4".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".Gene.138(1–2): 171–4.doi:10.1016/0378-1119(94)90802-8.PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".Gene.200(1–2): 149–56.doi:10.1016/S0378-1119(97)00411-3.PMID 9373149.
Uhl J, Penzel R, Sergi C, et al. (2002)."Identification of a CTL4/Neu1 fusion transcript in a sialidosis patient".FEBS Lett.521(1–3): 19–23.doi:10.1016/S0014-5793(02)02748-5.PMID 12067718.S2CID 23180217.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003)."The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment".Genome Res.13(10): 2265–70.doi:10.1101/gr.1293003.PMC403697.PMID 12975309.
Mungall AJ, Palmer SA, Sims SK, et al. (2003)."The DNA sequence and analysis of human chromosome 6".Nature.425(6960): 805–11.Bibcode:2003Natur.425..805M.doi:10.1038/nature02055.PMID 14574404.
Xie T, Rowen L, Aguado B, et al. (2004)."Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse".Genome Res.13(12): 2621–36.doi:10.1101/gr.1736803.PMC403804.PMID 14656967.
Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36(1): 40–5.doi:10.1038/ng1285.PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006)."Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes".Genome Res.16(1): 55–65.doi:10.1101/gr.4039406.PMC1356129.PMID 16344560.

Thismembrane protein–related article is astub.You can help Wikipedia byexpanding it.

[refGRCh38Ensembl-1] ENSG00000204385, ENSG00000231479, ENSG00000228263, ENSG00000206378, ENSG00000235336, ENSG00000229077, ENSG00000203463 GRCh38: Ensembl release 89: ENSG00000232180, ENSG00000204385, ENSG00000231479, ENSG00000228263, ENSG00000206378, ENSG00000235336, ENSG00000229077, ENSG00000203463–Ensembl,May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000007034–Ensembl,May 2017

[3] "Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10677542-5] O'Regan S, Traiffort E, Ruat M, Cha N, Compaore D, Meunier FM (Mar 2000)."An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins".Proc Natl Acad Sci U S A.97(4): 1835–40.Bibcode:2000PNAS...97.1835O.doi:10.1073/pnas.030339697.PMC26522.PMID 10677542.

[pmid15715662-6] Traiffort E, Ruat M, O'Regan S, Meunier FM (Feb 2005)."Molecular characterization of the family of choline transporter-like proteins and their splice variants".J Neurochem.92(5): 1116–25.doi:10.1111/j.1471-4159.2004.02962.x.PMID 15715662.S2CID 30921826.

[entrez-7] "Entrez Gene: SLC44A4 solute carrier family 44, member 4".

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Choline transporter-like protein 4

See also

References

Further reading