SOX2OT

SOX2-OT
Identifiers
Aliases	SOX2-OT,NCRNA00043, SOX2 overlapping transcript
External IDs	OMIM:616338;GeneCards:SOX2-OT;OMA:SOX2-OT - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	181,836,880bp
RNA expressionpattern
	Top expressed in
	corpus callosum; ; subthalamic nucleus; ; inferior ganglion of vagus nerve; ; external globus pallidus; ; pars reticulata; ; C1 segment; ; medulla oblongata; ; pons; ; superior vestibular nucleus; ; Pars compacta;
	n/a
	More reference expression data
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Orthologs
	347689
	n/a
	ENSG00000242808
	n/a
	n; a
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	n/a
	n/a
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	Wikidata
View/Edit Human

SOX2 overlapping transcript (SOX2OT) is along non-coding RNA,containing at least 5exons.TheSOX2gene, an important regulator ofneurogenesis,lies within one of theintronsof SOX2OT.^[3]SOX2OT and SOX2DOT (anisoformof SOXOT transcribed from a distal highly conserved element) are expressed in zones of neurogenesis within the brain. It is associated withcentral nervous systemstructures inzebrafishand chicken embryonic brains, and is dynamically regulated duringembryogenesis.^[4]SOX2OT may play a role in vertebrate development.^[4]

References

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000242808–Ensembl,May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Fantes J, Ragge NK, Lynch SA, et al. (April 2003)."Mutations in SOX2 cause anophthalmia".Nat. Genet.33(4): 461–3.doi:10.1038/ng1120.PMID 12612584.
^^a ^bAmaral PP, Neyt C, Wilkins SJ, et al. (November 2009)."Complex architecture and regulated expression of the Sox2ot locus during vertebrate development".RNA.15(11): 2013–27.doi:10.1261/rna.1705309.PMC2764477.PMID 19767420.

Strausberg RL, Feingold EA, Grouse LH, et al. (2002)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID 12477932.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006)."Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes".Genome Res.16(1): 55–65.doi:10.1101/gr.4039406.PMC1356129.PMID 16344560.
Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36(1): 40–5.doi:10.1038/ng1285.PMID 14702039.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000242808–Ensembl,May 2017

[2] "Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12612584-3] Fantes J, Ragge NK, Lynch SA, et al. (April 2003)."Mutations in SOX2 cause anophthalmia".Nat. Genet.33(4): 461–3.doi:10.1038/ng1120.PMID 12612584.

[pmid19767420-4] Amaral PP, Neyt C, Wilkins SJ, et al. (November 2009)."Complex architecture and regulated expression of the Sox2ot locus during vertebrate development".RNA.15(11): 2013–27.doi:10.1261/rna.1705309.PMC2764477.PMID 19767420.

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[3]

[4]

SOX2OT

See also

References

Further reading