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Sexually transmitted infection

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Sexually transmitted infection
Other namesSexually transmitted disease (STD);
Venereal disease (VD)
Condom Museum, Bangkok
SpecialtyInfectious disease
SymptomsNone,vaginal discharge,penile discharge,ulcers on or around the genitals,pelvic pain[1]
ComplicationsInfertility[1]
CausesInfections commonlyspreadbysex[1]
PreventionSexual abstinence,vaccinations,condoms[2]
Frequency1.1 billion (STIs other than HIV/AIDS, 2015)[3]
Deaths108,000 (STIs other than HIV/AIDS, 2015)[4]

Asexually transmitted infection(STI), also referred to as asexually transmitted disease(STD) and the older termvenereal disease(VD), is aninfectionthat isspreadbysexual activity,especiallyvaginal intercourse,anal sex,oral sex,or sometimesmanual sex.[1][5][6]STIs often do not initially cause symptoms,[1]which results in a risk of transmitting them on to others.[7][8]The termsexually transmitted infectionis generally preferred oversexually transmitted diseaseorvenereal disease,as it includes cases with nosymptomatic disease.[9]Symptoms and signs of STIs may includevaginal discharge,penile discharge,ulcers on or around the genitals,andpelvic pain.[1]Some STIs can causeinfertility.[1]

Bacterial STIs includechlamydia,gonorrhea,andsyphilis.[1]Viral STIs includegenital warts,genital herpes,andHIV/AIDS.[1]Parasitic STIs includetrichomoniasis.[1]Most STIs are treatable and curable, of the most common infections; syphilis, gonorrhea, chlamydia, and trichomoniasis are curable, while HIV/AIDS and genital herpes are not curable.[1]Somevaccinationsmay decrease the risk of certain infections includinghepatitis Band few types ofHPV.[2]Safe sexpractices such as use ofcondoms,having smaller number of sexual partners, and being in a relationship in which each person only has sex with the other also decreases STIs risk.[1][2]Comprehensive sex educationmay also be useful.[10]

STI diagnostic tests are usually easily available in thedeveloped world,but they are often unavailable in thedeveloping world.[1]There is often shame andstigmaassociated with STIs.[1]In 2015, STIs other than HIV resulted in 108,000 deaths worldwide.[4]Globally, in 2015, about 1.1 billion people had STIs other than HIV/AIDS.[3]About 500 million have either syphilis, gonorrhea, chlamydia or trichomoniasis.[1]At least an additional 530 million have genital herpes, and 290 million women havehuman papillomavirus.[1]Historical documentation of STIs inantiquitydates back to at least theEbers Papyrus(c. 1550 BCE) and theHebrew Bible/Old Testament(8th/7th C. BCE).[11]

Signs and symptoms

Not all STIs aresymptomatic,and symptoms may not appear immediately after infection. In some instances a disease can be carried with no symptoms, which leaves a greater risk of passing the disease on to others. Depending on the disease, some untreated STIs can lead toinfertility,chronic painor death.[12]

The presence of an STI inprepubescentchildren may indicatesexual abuse.[13]

Cause

Transmission

A sexually transmitted infection present in a pregnant woman may be passed on to the infant before or after birth.[14]

Risk of transmission per unprotected sexual act with an infected person[15][16][17][18][19][20][21][22][23][24][25][26][27]
Known risks Possible
Performing oral sex on a man
Performing oral sex on a woman
Receiving oral sex—man
Receiving oral sex—woman
Vaginal sex—man
Vaginal sex—woman
Anal sex—insertive
Anal sex—receptive
Anilingus

Bacterial

Viral

Micrographshowing the viralcytopathic effectof herpes (ground glass nuclear inclusions, multi-nucleation).Pap test.Pap stain.

Parasites

Main types

Sexually transmitted infections include:

  • Chlamydiais a sexually transmitted infection caused by the bacteriumChlamydia trachomatis.In women, symptoms may include abnormal vaginal discharge, burning during urination, and bleeding in between periods, although most women do not experience any symptoms.[60]Symptoms in men include pain when urinating, and abnormal discharge from their penis.[61]If left untreated in both men and women, chlamydia can infect the urinary tract and potentially lead topelvic inflammatory disease(PID). PID can cause serious problems during pregnancy and even has the potential to cause infertility. It can cause a woman to have a potentially deadlyectopic pregnancy,in which the egg implants outside of the uterus. However, chlamydia can be cured with antibiotics.
  • The two most common forms ofherpesare caused by infection withherpes simplex virus(HSV). HSV-1 is typically acquired orally and causes cold sores; HSV-2 is usually acquired during sexual contact and affects the genitals; however, either strain may affect either site.[62]Some people are asymptomatic or have very mild symptoms. Those that do experience symptoms usually notice them 2 to 20 days after exposure which lasts 2 to 4 weeks. Symptoms can include small fluid-filled blisters, headaches, backaches, itching or tingling sensations in the genital or anal area, pain during urination,flu like symptoms,swollen glands, or fever. Herpes is spread through skin contact with a person infected with the virus. The virus affects the areas where it entered the body. This can occur through kissing, vaginal intercourse, oral sex or anal sex. The virus is most infectious during times when there are visible symptoms; however, those who are asymptomatic can still spread the virus through skin contact.[63]The initial infection and symptoms are usually the most severe because the body does not have any antibodies built up. After the primary attack, one might have recurring attacks that are milder or might not even have future attacks. There is no cure for the disease but there are antiviral medications that treat its symptoms and lower the risk of transmission (Valtrex). Although HSV-1 is typically the "oral" version of the virus, and HSV-2 is typically the "genital" version of the virus, a person with HSV-1 orally can transmit that virus to their partner genitally. The virus, either type, will settle into a nerve bundle either at the top of the spine, producing the "oral" outbreak, or a second nerve bundle at the base of the spine, producing the genital outbreak.
  • Thehuman papillomavirus(HPV) is the most common STI in the United States.[64]There are more than 40 different strands of HPV and many do not cause any health problems. In 90% of cases, the body's immune system clears the infection naturally within two years.[65]Some cases may not be cleared and can lead to genital warts (bumps around the genitals that can be small or large, raised or flat, or shaped like cauliflower) or cervical cancer and other HPV related cancers. Symptoms might not show up until advanced stages. It is important for women to get pap smears in order to check for and treat cancers. There are also two vaccines available for women (CervarixandGardasil) that protect against the types of HPV that cause cervical cancer. HPV can be passed through genital-to-genital contact as well as during oral sex. The infected partner might not have any symptoms.
  • Gonorrheais caused by bacterium that lives on moist mucous membranes in the urethra, vagina, rectum, mouth, throat, and eyes. The infection can spread through contact with the penis, vagina, mouth, or anus. Symptoms of gonorrhea usually appear two to five days after contact with an infected partner; however, some men might not notice symptoms for up to a month. Symptoms in men include burning and pain while urinating, increased urinary frequency, discharge from the penis (white, green, or yellow in color), red or swollen urethra, swollen or tender testicles, or sore throat. Symptoms in women may include vaginal discharge, burning or itching while urinating, painful sexual intercourse, severe pain in lower abdomen (if infection spreads to fallopian tubes), or fever (if infection spreads to fallopian tubes); however, many women do not show any symptoms.[66]Antibiotic resistant strains of Gonorrhea are a significant concern, but most cases can be cured with existing antibiotics.
Secondary syphilis
  • Syphilisis an STI caused by a bacterium. Untreated, it can lead to complications and death.[67]Clinical manifestations of syphilis include the ulceration of the uro-genital tract, mouth or rectum; if left untreated the symptoms worsen. In recent years, the prevalence of syphilis has declined in Western Europe, but it has increased in Eastern Europe (former Soviet states). A high incidence of syphilis can be found in places such asCameroon,Cambodia,Papua New Guinea.[68]Syphilis infections are increasing in the United States.[69]
  • Trichomoniasisis a common STI that is caused by infection with a protozoan parasite calledTrichomonas vaginalis.[70]Trichomoniasis affects both women and men, but symptoms are more common in women.[71]Most patients are treated with an antibiotic called metronidazole, which is very effective.[72]
  • HIV(human immunodeficiency virus) damages the body's immune system, which interferes with its ability to fight off disease-causing agents. The virus killsCD4cells, which are white blood cells that help fight off various infections. HIV is carried in body fluids and is spread by sexual activity. It can also be spread by contact with infected blood, breastfeeding, childbirth, and from mother to child during pregnancy.[73]When HIV is at its most advanced stage, an individual is said to haveAIDS(acquired immunodeficiency syndrome).[74]There are different stages of the progression of and HIV infection. The stages includeprimary infection,asymptomatic infection, symptomatic infection, and AIDS. In the primary infection stage, an individual will have flu-like symptoms (headache, fatigue, fever, muscle aches) for about two weeks. In the asymptomatic stage, symptoms usually disappear, and the patient can remain asymptomatic for years. When HIV progresses to the symptomatic stage, the immune system is weakened and has a low cell count of CD4+T cells.When the HIV infection becomes life-threatening, it is called AIDS. People with AIDS fall prey to opportunistic infections and die as a result.[60]When the disease was first discovered in the 1980s, those who had AIDS were not likely to live longer than a few years. There are now antiretroviral drugs (ARVs) available to treat HIV infections. There is no known cure for HIV or AIDS but the drugs help suppress the virus. By suppressing the amount of virus in the body, people can lead longer and healthier lives. Even though their virus levels may be low they can still spread the virus to others.[75]

Viruses in semen

Twenty-seven different viruses have been identified in semen. Information on whether or not transmission occurs or whether the viruses cause disease is uncertain. Some of these microbes are known to be sexually transmitted.[76]

Pathophysiology

Many STIs are (more easily) transmitted through themucous membranesof thepenis,vulva,rectum,urinary tractand (less often—depending on type of infection) themouth,throat,respiratory tractandeyes.[77]The visible membrane covering thehead of the penisis a mucous membrane, though it produces nomucus(similar to thelipsof the mouth). Mucous membranes differ fromskinin that they allow certain pathogens into the body. The amount of contact with infective sources which causes infection varies with each pathogen but in all cases, a disease may result from even light contact from fluid carriers like venereal fluids onto a mucous membrane.[citation needed]

Some STIs such as HIV can be transmitted from mother to child either during pregnancy or breastfeeding.[78][79] Healthcare professionals suggestsafer sex,such as the use ofcondoms,as a reliable way of decreasing the risk of contracting sexually transmitted infections during sexual activity, but safer sex cannot be considered to provide complete protection from an STI. The transfer of and exposure to bodily fluids, such asblood transfusionsand other blood products, sharing injectionneedles,needle-stick injuries (when medical staff are inadvertently jabbed or pricked with needles during medical procedures), sharingtattooneedles, and childbirth are other avenues of transmission. These different means put certain groups, such as medical workers, andhaemophiliacsand drug users, particularly at risk.[citation needed]

It is possible to be anasymptomaticcarrier of sexually transmitted infections. In particular, sexually transmitted infections in women often cause the serious condition of pelvic inflammatory disease.[80]

Diagnosis

World War IIUS Army poster warning of venereal disease

Testingmay be for a single infection, or consist of a number of tests for a range of STIs, including tests forsyphilis,trichomonas,gonorrhea,chlamydia,herpes,hepatitis,andHIV.No procedure tests for all infectious agents.

STI tests may be used for a number of reasons:

  • as adiagnostic testto determine the cause of symptoms or illness
  • as ascreening testto detect asymptomatic or presymptomaticinfections
  • as a check that prospective sexual partners are free of disease before they engage in sex withoutsafer sexprecautions (for example, when starting a long term mutually monogamous sexual relationship, influid bonding,or for procreation).
  • as a check prior to or during pregnancy, to prevent harm to the baby
  • as a check after birth, to check that the baby has not caught an STI from the mother
  • to prevent the use of infecteddonated bloodororgans
  • as part of the process ofcontact tracingfrom a known infected individual
  • as part of massepidemiologicalsurveillance

Early identification and treatment results in less chance to spread disease, and for some conditions may improve the outcomes of treatment. There is often awindow periodafter initial infection during which an STI test will be negative. During this period, the infection may be transmissible. The duration of this period varies depending on the infection and the test. Diagnosis may also be delayed by reluctance of the infected person to seek a medical professional. One report indicated that people turn to the Internet rather than to a medical professional for information on STIs to a higher degree than for other sexual problems.[81]

Classification

A poster from theOffice for Emergency Management,Office of War Information,1941–1945

Until the 1990s,[citation needed]STIs were commonly known asvenereal diseases,an antiquatedeuphemismderived from the Latinvenereus,being the adjectival form ofVenus,theRoman goddessof love.[82]However, in the post-classical education era the euphemistic effect was entirely lost, and the common abbreviation "VD" held only negative connotations. Other former euphemisms for STIs include "blood diseases" and "social diseases".[83]The present euphemism is in the use of the initials "STI" rather than in the words they represent. TheWorld Health Organization(WHO) has recommended the more inclusive termsexually transmitted infectionsince 1999.[9]Public healthofficials originally introduced the termsexually transmitted infection,which clinicians are increasingly using alongside the termsexually transmitted diseasein order to distinguish it from the former.[citation needed]

Prevention

Main article:Safe sex

Strategies for reducing STI risk include: vaccination,mutual monogamy,reducing the number of sexual partners, and abstinence.[84]Also potentially helpful is behavioral counseling for sexually active adolescents and for adults who are at increased risk.[85]Such interactive counseling, which can be resource-intensive, is directed at a person's risk, the situations in which risk occurs, and the use of personalized goal-setting strategies.[86]

The most effective way to prevent sexual transmission of STIs is to avoid contact of body parts or fluids which can lead to transfer with an infected partner. Not all sexual activities involve contact:cybersex,phone sexormasturbationfrom a distance are methods of avoiding contact. Proper use of condoms reduces contact and risk. Although a condom is effective in limiting exposure, some disease transmission may occur even with a condom.[87]

"Syphilis is a dangerous disease, but it can be cured". Poster encouraging treatment. Published between 1936 and 1938.

Both partners can get tested for STIs before initiating sexual contact, or before resuming contact if a partner engaged in contact with someone else. Many infections are not detectable immediately after exposure, so enough time must be allowed between possible exposures and testing for the tests to be accurate. Certain STIs, particularly certain persistent viruses like HPV, may be impossible to detect.[medical citation needed]

Some treatment facilities use in-home test kits and have the person return the test for follow-up. Other facilities strongly encourage that those previously infected return to ensure that the infection has been eliminated. Novel strategies to foster re-testing have been the use of text messaging and email as reminders. These types of reminders are now used in addition to phone calls and letters.[88]After obtaining a sexual history, a healthcare provider can encourage risk reduction by providing preventioncounseling.Prevention counseling is most effective if provided in a nonjudgmental and empathetic manner appropriate to the person's culture, language, gender, sexual orientation, age, and developmental level. Prevention counseling for STIs is usually offered to all sexually active adolescents and to all adults who have received a diagnosis, have had an STI in the past year, or havemultiple sex partners.[86]

Vaccines

Vaccines are available that protect against some viral STIs, such ashepatitis A,hepatitis B,and some types ofHPV.[89]Vaccination before initiation of sexual contact is advised to assure maximal protection. The development of vaccines to protect against gonorrhea is ongoing.[90]

Condoms

Condoms andfemale condomsonly provide protection when used properly as a barrier, and only to and from the area that they cover. Uncovered areas are still susceptible to many STIs.[citation needed]

In the case of HIV, sexual transmission routes almost always involve the penis, as HIV cannot spread through unbroken skin; therefore, properly shielding the penis with a properly worn condom from the vagina or anus effectively stops HIV transmission. An infected fluid to broken skin borne direct transmission of HIV would not be considered "sexually transmitted", but can still theoretically occur during sexual contact. This can be avoided simply by not engaging in sexual contact when presenting open, bleeding wounds.[citation needed]

Other STIs, even viral infections, can be prevented with the use of latex, polyurethane or polyisoprene condoms as a barrier. Some microorganisms and viruses are small enough to pass through the pores in natural skin condoms but are still too large to pass through latex or synthetic condoms.[citation needed]

Proper male condom usage entails:[citation needed]

  • Not putting the condom on too tight at the tip by leaving 1.5 centimetres (0.6 in) room forejaculation.Putting the condom on too tightly can and often does lead to failure.
  • Wearing a condom too loose can defeat the barrier
  • Avoiding inverting or spilling a condom once worn, whether it has ejaculate in it or not
  • If a user attempts to unroll the condom, but realizes they have it on the wrong side, then this condom may not be effective
  • Being careful with the condom if handling it with long nails
  • Avoiding the use of oil-based lubricants (or anything with oil in it) with latex condoms, as oil can eat holes into them
  • Using flavored condoms for oral sex only, as the sugar in the flavoring can lead to yeast infections if used to penetrate

In order to best protect oneself and the partner from STIs, the old condom and its contents are to be treated as infectious and properly disposed of. A new condom is used for each act of intercourse, as multiple usages increase the chance of breakage, defeating the effectiveness as a barrier.[citation needed]

In the case of female condoms, the device consists of two rings, one in each terminal portion. The larger ring should fit snugly over the cervix and the smaller ring remains outside the vagina, covering the vulva. This system provides some protection of the external genitalia.[91]

Other

Thecapwas developed after the cervicaldiaphragm.Both cover the cervix and the main difference between the diaphragm and the cap is that the latter must be used only once, using a new one in each sexual act. The diaphragm, however, can be used more than once. These two devices partially protect against STIs (they do not protect against HIV).[92]

Researchers had hoped thatnonoxynol-9,a vaginal microbicide would help decrease STI risk. Trials, however, have found it ineffective[93]and it may put women at a higher risk of HIV infection.[94]There is evidence that vaginaldapivirineprobably reduces HIV in women who have sex with men, other types of vaginal microbicides have not demonstrated effectiveness for HIV or STIs.[95]

There is little evidence that school-based interventions such as sexual and reproductive health education programmes on contraceptive choices and condoms are effective on improving the sexual and reproductive health of adolescents. Incentive-based programmes may reduce adolescent pregnancy but more data is needed to confirm this.[96]

Screening

Specific age groups, persons who participate in risky sexual behavior, or those have certain health conditions may require screening. The CDC recommends that sexually active women under the age of 25 and those over 25 at risk should be screened for chlamydia and gonorrhea yearly. Appropriate times for screening are during regular pelvic examinations and preconception evaluations.[97]Nucleic acid amplification testsare the recommended method of diagnosis for gonorrhea and chlamydia.[98]This can be done on either urine in both men and women, vaginal or cervical swabs in women, or urethral swabs in men.[98]Screening can be performed:

  • to assess the presence of infection and prevent tubal infertility in women
  • during the initial evaluation before infertility treatment
  • to identify HIV infection
  • formen who have sex with men
  • for those who may have been exposed to hepatitis C
  • for HCV[98]

Management

In the case of rape, the person can be treated prophylacticly with antibiotics.[99]

An option for treating partners of patients (index cases) diagnosed withchlamydiaor gonorrhea ispatient-delivered partner therapy,which is the clinical practice of treating the sex partners of index cases by providing prescriptions or medications to the patient to take to his/her partner without the health care provider first examining the partner.[100][needs update]In term of preventing reinfection in sexually transmitted infection, treatment with both patient and the sexual partner of patient resulted in more successful than treatment of the patient without the sexual partner. There is no difference in reinfection prevention whether the sexual partner treated with medication without medical examination or after notification by patient.[101]

Epidemiology

See also:List of sexually transmitted infections by prevalence
Age-standardized,disability-adjusted life yearsWHOestimates for STIs (excluding HIV) per 100,000 inhabitants in 2004.[102]
STI (excluding HIV) deaths per million persons in 2012[citation needed]
0–0
1–1
2–3
4–9
10–18
19–31
32–55
56–139

]]

In 2008, it was estimated that 500 million people were infected with either syphilis, gonorrhea, chlamydia or trichomoniasis.[1]At least an additional 530 million people have genital herpes and 290 million women havehuman papillomavirus(HPV).[1]STIs other than HIV resulted in 142,000 deaths in 2013.[103]In the United States there were 19 million new cases of sexually transmitted infections in 2010.[104]

In 2010, 19 million new cases of sexually transmitted infections occurred in women in the United States.[5]A 2008CDCstudy found that 25–40% of U.S. teenage girls has a sexually transmitted infection.[105][106]Out of a population of almost 295,270,000 people[107]there were 110 million new and existing cases of eight sexually transmitted infections.[108]

Over 400,000 sexually transmitted infections were reported in England in 2017, about the same as in 2016, but there were more than 20% increases in confirmed cases of gonorrhoea and syphilis. Since 2008 syphilis cases have risen by 148%, from 2,874 to 7,137, mostly amongmen who have sex with men.The number of first cases of genital warts in 2017 among girls aged 15–17 years was just 441, 90% less than in 2009 – attributed to the national HPV immunisation programme.[109]

AIDSis among the leading causes of death in present-daySub-Saharan Africa.[110]HIV/AIDS is transmitted primarily via unprotected sexual intercourse. More than 1.1 million persons are living withHIV/AIDS in the United States,[111]and it disproportionately impactsAfrican Americans.[112]Hepatitis Bis also considered a sexually transmitted infection because it can be spread through sexual contact.[113]The highest rates are found in Asia and Africa and lower rates are in the Americas and Europe.[114]Approximately two billion people worldwide have been infected with the hepatitis B virus.[115]

History

The first well-recorded European outbreak of what is now known as syphilis occurred in 1494 when it broke out among French troops besiegingNaplesin theItalian War of 1494–98.[116]The disease may have originated from theColumbian Exchange.[117][118]From Naples, the disease swept acrossEurope,killing more than five million people.[119]AsJared Diamonddescribes it, "[W]hen syphilis was first definitely recorded in Europe in 1495, itspustulesoften covered the body from the head to the knees, caused flesh to fall from people's faces, and led to death within a few months, "rendering it far morefatalthan it is today. Diamond concludes, "[B]y 1546, the disease had evolved into the disease with the symptoms so well known to us today."[120]Gonorrhea is recorded at least up to 700 years ago and associated with a district in Paris formerly known as "Le Clapiers". This is where the prostitutes were to be found at that time.[90]

Prior to the invention of modern medicines, sexually transmitted infections were generally incurable, and treatment was limited to treating the symptoms of the infection. The first voluntary hospital for STIs was founded in 1746 atLondon Lock Hospital.[121]Treatment was not always voluntary: in the second half of the 19th century, theContagious Diseases Actswere used to arrest suspected prostitutes. In 1924, a number of states concluded theBrussels Agreement,whereby states agreed to provide free or low-cost medical treatment at ports for merchant seamen with STIs. A proponent of these approaches wasNora Wattie,OBE, Venereal Diseases Officer in Glasgow from 1929, encouragedcontact tracingand volunteering for treatment, rather than the prevailing more judgemental view and published her own research on improving sex education and maternity care.[122]

The first effective treatment for a sexually transmitted infection wassalvarsan,a treatment for syphilis. With the discovery ofantibiotics,a large number of sexually transmitted infections became easily curable, and this, combined with effective public health campaigns against STIs, led to a public perception during the 1960s and 1970s that they have ceased to be a serious medical threat.[citation needed]

During this period, the importance of contact tracing in treating STIs was recognized. By tracing the sexual partners of infected individuals, testing them for infection, treating the infected and tracing their contacts, in turn, STI clinics could effectively suppress infections in the general population.[citation needed]

In the 1980s, first genital herpes and thenAIDSemerged into the public consciousness as sexually transmitted infections that could not be cured by modern medicine. AIDS, in particular, has a long asymptomatic period—during which timeHIV(the human immunodeficiency virus, which causes AIDS) can replicate and the disease can be transmitted to others—followed by a symptomatic period, which leads rapidly to death unless treated. HIV/AIDS entered the United States from Haiti in about 1969.[123]Recognition that AIDS threatened a globalpandemicled to public information campaigns and the development of treatments that allow AIDS to be managed by suppressing the replication of HIV for as long as possible. Contact tracing continues to be an important measure, even when diseases are incurable, as it helps to contain infection.

  • World War II–era British poster urging men to be tested for sexually transmitted infections before marriage
    World War II–era British poster urging men to be tested for sexually transmitted infections before marriage
  • U.S. propaganda poster targeted at World War II servicemen appealed to their patriotism in urging them to protect themselves. The text at the bottom of the poster reads, "You can't beat the Axis if you get VD".
    U.S. propaganda poster targeted atWorld War IIservicemen appealed to their patriotism in urging them to protect themselves. The text at the bottom of the poster reads, "You can't beat theAxisif you get VD ".

See also

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