SYT6
Appearance
Synaptotagmin-6is aproteinthat in humans is encoded by theSYT6gene.[5][6]
Function
[edit]Synaptotagmins, such as SYT6, share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains. Some synaptotagmins are involved in synaptic membrane fusion, while others have a more general function in endocytosis. For further information on synaptotagmins, see MIM 185605.[supplied by OMIM][6]
References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000134207–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000027849–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Craxton M (September 2001). "Genomic analysis of synaptotagmin genes".Genomics.77(1–2): 43–9.doi:10.1006/geno.2001.6619.PMID11543631.
- ^ab"Entrez Gene: SYT6 synaptotagmin VI".
Further reading
[edit]- Roggero CM, Tomes CN, De Blas GA, Castillo J, Michaut MA, Fukuda M, Mayorga LS (September 2005)."Protein kinase C-mediated phosphorylation of the two polybasic regions of synaptotagmin VI regulates their function in acrosomal exocytosis".Developmental Biology.285(2): 422–35.doi:10.1016/j.ydbio.2005.07.007.PMID16111671.
- Michaut M, De Blas G, Tomes CN, Yunes R, Fukuda M, Mayorga LS (July 2001)."Synaptotagmin VI participates in the acrosome reaction of human spermatozoa".Developmental Biology.235(2): 521–9.doi:10.1006/dbio.2001.0316.PMID11437455.
- Perin MS (October 1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin".Biochemistry.35(43): 13808–16.doi:10.1021/bi960853x.PMID8901523.
- Li C, Ullrich B, Zhang JZ, Anderson RG, Brose N, Südhof TC (June 1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins".Nature.375(6532): 594–9.Bibcode:1995Natur.375..594L.doi:10.1038/375594a0.PMID7791877.S2CID4265549.