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Sangeeta Bhatia

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Sangeeta N. Bhatia
Bhatia in 2023 at MIT
Born(1968-06-24)June 24, 1968(age 56)
NationalityAmerican
CitizenshipAmerican
Alma materBrown University(B.S.)
Massachusetts Institute of Technology(M.S., Ph.D.)
Harvard Medical School(M.D.)
Known forNanotechnology for tissue repair and regeneration
AwardsPackard Fellowship(1999–2004)
Howard Hughes Medical Instituteinvestigator (2008)
Lemelson–MIT Prize
Heinz Award(2015)
Othmer Gold Medal(2019)
Scientific career
FieldsNanotechnology,Tissue engineering
InstitutionsMassachusetts General Hospital
University of California, San Diego(1998–2005)
Massachusetts Institute of Technology(2005– )
Academic advisorsMehmet Toner
External videos
video icon“This tiny particle could roam your body to find tumors”,Sangeeta Bhatia, TED Talks Live, November 2015
video icon“Sangeeta Bhatia, 2014 Lemelson-MIT Prize Winner “,January 29, 2015

Sangeeta N. Bhatia(born 1968) is an Americanbiological engineerand the John J. and Dorothy Wilson Professor atMIT’s Institute for Medical Engineering and Science and Electrical Engineering and Computer Science (EECS) at theMassachusetts Institute of Technology(MIT) inCambridge, Massachusetts,United States. Bhatia's research investigates applications of micro- and nano-technology for tissue repair and regeneration. She applies ideas from computer technology and engineering to the design of miniaturized biomedical tools for the study and treatment of diseases, in particularliver disease,hepatitis,malariaand cancer.[1]

In 2003, she was named by theMIT Technology Reviewas one of the top100 innovatorsin the world under the age of 35.[2][3] She was also named a "Scientist to Watch" byThe Scientistin 2006.[4] She has received multiple awards and has been elected to theNational Academy of Sciences,[5]theNational Academy of Engineering,[6]theNational Academy of Medicine,[7]and theNational Academy of Inventors.[8]

Bhatia's dissertation became the basis forMicrofabrication in tissue engineering and bioartificial organs(1999).[9] Bhatia co-authored the first undergraduate textbook ontissue engineering,Tissue engineering(2004), written for senior-level and first-year graduate courses withBernhard Palsson.[10] She was a co-editor ofMicrodevices in Biology and Medicine(2009)[11] andBiosensing: International Research and Development(2005).[12]

Early life and education[edit]

Bhatia's parents emigrated from India toBoston,Massachusetts; her father was an engineer and her mother was one of the first women to receive anMBAin India. Bhatia was motivated to become an engineer after her 10th grade biology class and a trip with her father into an MIT lab to see a demonstration of anultrasound machinefor cancer treatment.[13]

Bhatia studied bioengineering atBrown Universitywhere she joined a research group studyingartificial organswhich convinced her to pursue graduate study the field.[14]After graduating with honors in 1990,[15] Bhatia was initially rejected from theMD-PhDprogram run by theHarvard-MIT Division of Health Sciences and Technology(HST) but was accepted into theMechanical Engineeringmasters program. She was later accepted to the HST MD-PhD program where she was advised byMehmet TonerandMartin Yarmush.She received a PhD in 1997 and an MD in 1999, and completed postdoctoral training atMassachusetts General Hospital.[13][15]

Career[edit]

Bhatia joined the faculty at theUniversity of California, San Diego(UCSD) in 1998.[16]As an assistant professor, Bhatia was awarded a five-year Packard Fellowship for Science and Engineering from theDavid and Lucile Packard Foundationin 1999.[16]She was named a 2001 "Teacher of the Year" in the Bioengineering Department at theJacobs School of Engineering,[17] and was named an Innovator under 35 byMIT Technology Reviewin 2003.[3]

In 2005, she left UCSD and joined the MIT faculty in the Division of Health Sciences & Technology and theDepartment of Electrical Engineering and Computer Science.Bhatia was named a "Scientist to Watch" byThe Scientistin 2006 and became aHoward Hughes Medical Instituteinvestigator in 2008.[4][18][19]

Bhatia currently directs the Laboratory for Multiscale Regenerative Technologies at MIT and is affiliated withBrigham and Women's Hospitaland theKoch Institute for Integrative Cancer Research.[20] Bhatia is a strong advocate for gender equity and inclusivity inSTEM fields.[21] Bhatia helped to found the Diversity Committee of theBiomedical Engineering Society,and is involved with MIT'sSociety of Women Engineers.[1]While at MIT, she helped to start Keys to Empowering Youth, a program that brings middle-school girls to visit hi-tech labs as a way to encourage them in science and technology.[22]Bhatia and her husband, Jagesh Shah have two daughters.[13][22]

In 2015, Bhatia was elected a member of theNational Academy of Engineeringfor tissue engineering and tissue regeneration technologies, stem cell differentiation, and preclinical drug evaluation.

Research[edit]

Bhatia's doctoral work focused on the development of a way to keep liver cells functioning outside of the human body.[23]She adapted ideas from computer chip design and engineering to the microfabrication of a substrate for liver cells.[24] She successfully applied techniques fromphotolithographytopetri dishes,to create a substrate that would support growth of a functioning microliver in a dish.[1][24][25] Bhatia also used co-cultures of more than one cell type to preventdedifferentiationof the liver cells, building on the work ofChristiane Guguen-Guillouzoin France.[24] She and her coworkers have also used techniques from3D printingto create a lattice of sugar as a framework for a syntheticvascular systemwith the goal of supporting larger tissue structures such as an artificial liver.[26] Her work was one of the first projects at MIT in the area of biological micro-electromechanical systems, orBio-MEMS.[24][27]She is interested in using arrays of living cells as high-throughput platforms to study fundamental aspects of Bio-MEMS instem cells.[27][28]

Bhatia's research in the Laboratory for Multiscale Regenerative Technologies (LMRT) continues to apply micro- and nanotechnology ideas to tissue repair and regeneration.[29] She studies the interactions betweenhepatocytes(liver cells) and their microenvironment and develops microfabrication tools to improve cellular therapies for liver disease in an approach referred to as hepatic tissue engineering.[30][31] The goal is to maximize hepatocyte function,[32][33] facilitate design of effective cellular therapies for liver disease,[30]and improve fundamental understanding of liver physiology and pathophysiology.[34] The approach has been used to study diseases includinghepatitisandmalaria.[1][35]

Since 2008, with assistance from theMedicines for Malaria Venture(MMV), and theBill & Melinda Gates Foundationher lab has worked on the development ofPlasmodium falciparumandPlasmodium vivaxcell-based assays. These are used to support the study of parasites and explore possible differential drug sensitivity and identify new anti-relapse medicines formalaria.[36][37]

Bhatia's laboratory is also involved in a multidisciplinary effort to developnanomaterialsas tools for biological studies and as multifunctional agents for cancer therapies. Interests center aroundnanoparticlesandnanoporous materialsthat can be designed to perform complex tasks. They may be able to home in on a tumor, signal changes in cells or tissues, enhance imaging, or release a therapeutic component.[38] In 2002, Bhatia worked withErkki RuoslahtiandWarren Chanto develop phage-derived peptide-targeted nanomaterials, orquantum dots,forin vivotargeting of tumors.[24][39][40] By adding tumor-enzyme molecules to nanoparticles she has also created specialized nanoparticles that can react with diseased tissue to create syntheticbiomarkersdetectable in blood orurinesamples.[41]Another project involves engineering beneficialprobioticswith the ability to detect or treat cancer cells.[1]

Bhatia holds a number of patents for both clinical and biotechnological applications of engineering principles.[38]In 2015, her company Glympse Bio received initial funding fromKiran Mazumdar-ShawandTheresia Gouwat Aspect Ventures. In 2018, Glympse received $22 million to further develop “activity sensors” to identify diseases and monitor patient response to drugs.[42]

Books[edit]

  • Bhatia, Sangeeta (1999).Microfabrication in tissue engineering and bioartificial organs.Microsystems. Vol. 5. Boston: Kluwer Academic Publishers.doi:10.1007/978-1-4615-5235-2.ISBN978-1-4613-7386-5.
  • Palsson, Bernhard; Bhatia, Sangeeta (2004).Tissue engineering.Upper Saddle River, N.J.: Pearson Prentice Hall.ISBN0-13-041696-7.OCLC52960378.
  • Nahmias, Yaakov; Bhatia, Sangeeta (2009).Microdevices in biology and medicine.Boston: Artech House.ISBN978-1-59693-405-4.OCLC542050628.
  • Schultz, Jerome; Mrksich, Milan; Bhatia, Sangeeta N.; Brady, David J.; Ricco, Antionio J.; Walt, David R.; Wilkins, Charles L., eds. (July 15, 2006).Biosensing: International Research and Development.Springer Science & Business Media.ISBN978-1-4020-4058-0.

Awards[edit]

Bhatia is the recipient of a number of awards and honors including the following:

References[edit]

  1. ^abcdefVickmark, Bryce (September 9, 2014)."Cancer-Fighting Inventor Sangeeta Bhatia Wins $500,000 Prize".Science News.RetrievedMarch 11,2019.
  2. ^"2003 Innovators Under 35".MIT Technology Review.2003.RetrievedAugust 15,2011.
  3. ^ab"Innovators Under 35: Sangeeta Bhatia, 35".MIT Technology Review.2003.RetrievedSeptember 12,2009.
  4. ^abNadis, Steve (February 1, 2006)."Sangeeta Bhatia Looks at Life's Architecture".The Scientist.RetrievedSeptember 12,2009.
  5. ^"National Academy of Sciences elects six MIT professors for 2017".MIT News.RetrievedMay 11,2017.
  6. ^"Eight from MIT elected to National Academy of Engineering".MIT News.RetrievedMay 11,2017.
  7. ^"Two from MIT elected to the National Academy of Medicine for 2019".MIT News.RetrievedOctober 21,2019.
  8. ^"Four MIT faculty named 2015 fellows of the National Academy of Inventors".MIT News.RetrievedMay 11,2017.
  9. ^Bhatia, Sangeeta (1999).Microfabrication in tissue engineering and bioartificial organs.Microsystems. Vol. 5. Boston: Kluwer Academic Publishers.doi:10.1007/978-1-4615-5235-2.ISBN978-1-4613-7386-5.
  10. ^Palsson, Bernhard Ø.; Bhatia, Sangeeta N. (2004).Tissue engineering.Upper Saddle River, N.J.: Pearson Prentice Hall.
  11. ^Nahmias, Yaakov; Bhatia, Sangeeta N., eds. (2009).Microdevices in biology and medicine.Boston: Artech House.
  12. ^Schultz, Jerome; Mrksich, Milan; Bhatia, Sangeeta N.; Brady, David J.; Ricco, Antionio J.; Walt, David R.; Wilkins, Charles L., eds. (July 15, 2006).Biosensing: International Research and Development.Springer Science & Business Media.ISBN978-1-4020-4058-0.
  13. ^abcSeftel, Josh; Lewis, Susan K. (2009)."The Many Sides of Sangeeta Bhatia".NOVA Science Now.Public Broadcasting Service.RetrievedSeptember 12,2009.
  14. ^"Sangeeta N. Bhatia, MD, PhD Investigator / 2009—Present".Howard Hughes Medical Institute.RetrievedSeptember 12,2009.
  15. ^ab"People: Sangeeta N. Bhatia".Harvard-MIT Health Science & Technology. Archived fromthe originalon September 19, 2008.RetrievedSeptember 12,2009.
  16. ^abcHagen, Denine (December 1, 1999)."UC San Diego Bioengineering Professor Receives Prestigious Packard Foundation Fellowship".UCSD Jacobs School of Engineering.
  17. ^"Keiko Nomura Named Teacher of the Year".Pulse Newsletter.No. Winter. UCSD Jacobs School of Engineering. 2002.RetrievedSeptember 12,2009.Other 2001 Teacher of the Year award recipients include: Sangeeta Bhatia Bioengineering
  18. ^ab"The 2008 HHMI Investigators".Howard Hughes Medical Institute. May 27, 2008. Archived fromthe originalon February 27, 2009.RetrievedSeptember 12,2009.
  19. ^"Indian chosen for prestigious scientists' body".India Abroad.July 9, 2008.
  20. ^"Sangeeta N. Bhatia, MD, PhD".Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology.RetrievedSeptember 12,2009.
  21. ^"Sangeeta Bhatia: the biotech entrepreneur advocating for gender equity in STEM fields".The Guardian.RetrievedMarch 12,2019.
  22. ^abWood, Martha Crosier (May 26, 2015)."Scene and Herd: Bhatia wins Heinz Award, focuses on tissue engineering".Lexington Local.RetrievedMarch 11,2019.
  23. ^Rinde, Meir (July 9, 2019)."Interview: Sangeeta Bhatia Distillations talks to the 2019 Othmer Gold Medal winner about her work using nanotechnology to detect and treat disease".Distillations.Science History Institute.RetrievedDecember 6,2019.
  24. ^abcdeScudellari, Megan (May 1, 2013)."The Organist When molecular biology methods failed her, Sangeeta Bhatia turned to engineering and microfabrication to build a liver from scratch".The Scientist.RetrievedMarch 11,2019.
  25. ^"Engineering Artificial Organs".NOVA.June 1, 2009.RetrievedMarch 11,2019.
  26. ^"3D-printed sugar network to help grow artificial liver".BBC News.July 2, 2012.RetrievedMarch 12,2019.
  27. ^abChin, Vicki I.; Taupin, Philippe; Sanga, Sandeep; Scheel, John; Gage, Fred H.; Bhatia, Sangeeta N. (November 5, 2004)."Microfabricated platform for studying stem cell fates"(PDF).Biotechnology and Bioengineering.88(3): 399–415.doi:10.1002/bit.20254.PMID15486946.S2CID18023873.RetrievedMarch 11,2019.
  28. ^Borenstein, J. T.; Vunjak-Novakovic, G. (November 2011)."Engineering Tissue with BioMEMS".IEEE Pulse.2(6): 28–34.doi:10.1109/MPUL.2011.942764.PMC3414430.PMID22147066.
  29. ^Thalmann, Nadia (2014).3D Multiscale Physiological Human.London: Springer. p. 39.ISBN978-1-4471-6275-9.OCLC867854892.
  30. ^abBhatia, S. N.; Underhill, G. H.; Zaret, K. S.; Fox, I. J. (July 16, 2014)."Cell and tissue engineering for liver disease".Science Translational Medicine.6(245): 245sr2.doi:10.1126/scitranslmed.3005975.PMC4374645.PMID25031271.
  31. ^Shan, Jing; Stevens, Kelly R.; Trehan, Kartik; Underhill, Gregory H.; Chen, Alice A.; Bhatia, Sangeeta N."HEPATIC TISSUE ENGINEERING (ca. 2010)"(PDF).Laboratory for Multiscale Regenerative Technologies.RetrievedMarch 11,2019.[dead link]
  32. ^Bhatia, Sangeeta N. (1999).Microfabrication in Tissue Engineering and Bioartificial Organs.Springer US.ISBN978-1-4613-7386-5.RetrievedMarch 7,2019.
  33. ^Hui, E. E.; Bhatia, S. N. (March 27, 2007)."Micromechanical control of cell-cell interactions".Proceedings of the National Academy of Sciences.104(14): 5722–5726.doi:10.1073/pnas.0608660104.PMC1851558.PMID17389399.
  34. ^Park, J.-K.; Lee, S.-K.; Lee, D.-H.; Kim, Y.-J. (February 11, 2009)."Bioartificial Liver".In Meyer, Ulrich; Meyer, Thomas; Handschel, Jörg; Wiesmann, Hans Peter (eds.).Fundamentals of tissue engineering and regenerative medicine.Springer. p. 407.ISBN978-3-540-77755-7.RetrievedMarch 7,2019.
  35. ^"Tracking dormant malaria Novel technology could allow researchers to develop and test new antimalaria drugs".Science Daily.February 22, 2018.RetrievedMarch 11,2019.
  36. ^"Discovering new molecules to target the relapse Prof Sangeeta Bhatia Prof Sangeeta Bhatia, Director, Laboratory for Multiscale Regenerative Technologies, MIT".MMV.2013.RetrievedMarch 11,2019.
  37. ^March, Sandra; Ng, Shengyong; Velmurugan, Soundarapandian; Galstian, Ani; Shan, Jing; Logan, David J.; Carpenter, Anne E.; Thomas, David; Sim, B. Kim Lee; Mota, Maria M.; Hoffman, Stephen L.; Bhatia, Sangeeta N. (July 2013)."A Microscale Human Liver Platform that Supports the Hepatic Stages of Plasmodium falciparum and vivax".Cell Host & Microbe.14(1): 104–115.doi:10.1016/j.chom.2013.06.005.PMC3780791.PMID23870318.
  38. ^ab"Sangeeta Bhatia Core Faculty".Institute for Medical Engineering & Science.RetrievedMarch 11,2019.
  39. ^Akerman, M. E.; Chan, W. C. W.; Laakkonen, P.; Bhatia, S. N.; Ruoslahti, E. (September 16, 2002)."Nanocrystal targeting in vivo".Proceedings of the National Academy of Sciences.99(20): 12617–12621.Bibcode:2002PNAS...9912617A.doi:10.1073/pnas.152463399.PMC130509.PMID12235356.
  40. ^Mann, AP; Scodeller, P; Hussain, S; Joo, J; Kwon, E; Braun, GB; Mölder, T; She, Z; Kotamraju, VR; Ranscht, B; Krajewski, S; Teesalu, T; Bhatia, S; Sailor, MJ; Ruoslahti, E (2016)."A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries".Nat Commun.7:11980.Bibcode:2016NatCo...711980M.doi:10.1038/ncomms11980.PMC4931241.PMID27351915.
  41. ^Trafton, Anne (December 17, 2012)."Earlier Detection of Cancer May Be Enhanced by MIT Discovery with Biomarkers Collected in Urine".Senior Journal: Health & Medicine for Senior Citizens.New Tech Media.RetrievedMarch 12,2019.
  42. ^Carroll, John (October 9, 2018)."MIT spinout from Sangeeta Bhatia's lab gets a $22M round to develop new disease and drug sensors".Endpoints News.RetrievedMarch 11,2019.
  43. ^"Sangeeta Bhatia FTSE".Australian Academy of Technological Sciences and Engineering.RetrievedOctober 11,2023.
  44. ^"Othmer Gold Medal".Science History Institute.May 31, 2016.RetrievedMarch 7,2018.
  45. ^"Utrecht University to present two honorary doctorates".February 16, 2017.RetrievedApril 3,2018.
  46. ^"Announcing our 2017 Catalyst Award Winners!".Science Club for Girls community.RetrievedMarch 12,2019.
  47. ^"The Heinz Awards:: Sangeeta Bhatia".www.heinzawards.net.RetrievedApril 3,2018.
  48. ^"Dr. Sangeeta Bhatia - Lemelson-MIT Program".lemelson.mit.edu.RetrievedApril 3,2018.
  49. ^"BEAM Award Winners".Brown School of Engineering.RetrievedMarch 7,2019.

External links[edit]

Retrieved from "https://en.wikipedia.org/w/index.php?title=Sangeeta_Bhatia&oldid=1217408888"