Scytovirin
| Scytovirin | |
|---|---|
| Identifiers | |
| Organism | |
| Symbol | SVR |
Scytovirinis a 95-amino acidantiviralproteinisolated from thecyanobacteriaScytonema varium.[1]It has been cultured inE. coliand its structure investigated in detail.[2][3][4]Scytovirin is thought to be produced by the bacteria to protect itself from viruses that might otherwise attack it, but as it has broad-spectrum antiviral activity against a range of enveloped viruses, scytovirin has also been found to be useful against a range of major human pathogens, most notablyHIV/ AIDS but also includingSARS coronavirusandfilovirusessuch asEbola virusandMarburg virus.[5][6][7]While some lectins such ascyanovirinandUrtica dioicaagglutininare thought likely to be tooallergenicto be used internally in humans, studies so far on scytovirin and griffithsin have not shown a similar level of immunogenicity.[8]Scytovirin and griffithsin are currently being investigated as potentialmicrobicidesfor topical use.[9]
References
[edit]- ^Bokesch HR, O'Keefe BR, McKee TC, Pannell LK, Patterson GM, Gardella RS, Sowder RC, Turpin J, Watson K, Buckheit RW, Boyd MR (March 2003). "A potent novel anti-HIV protein from the cultured cyanobacterium Scytonema varium".Biochemistry.42(9): 2578–84.doi:10.1021/bi0205698.PMID12614152.
- ^Xiong C, O'Keefe BR, Botos I, Wlodawer A, McMahon JB (April 2006). "Overexpression and purification of scytovirin, a potent, novel anti-HIV protein from the cultured cyanobacterium Scytonema varium".Protein Expression and Purification.46(2): 233–9.doi:10.1016/j.pep.2005.09.019.PMID16289703.
- ^McFeeters RL, Xiong C, O'Keefe BR, Bokesch HR, McMahon JB, Ratner DM, Castelli R, Seeberger PH, Byrd RA (June 2007)."The novel fold of scytovirin reveals a new twist for antiviral entry inhibitors".Journal of Molecular Biology.369(2): 451–61.doi:10.1016/j.jmb.2007.03.030.PMC2696897.PMID17434526.
- ^Moulaei T, Stuchlik O, Reed M, Yuan W, Pohl J, Lu W, Haugh-Krumpe L, O'Keefe BR, Wlodawer A (September 2010)."Topology of the disulfide bonds in the antiviral lectin scytovirin".Protein Science.19(9): 1649–61.doi:10.1002/pro.445.PMC2975129.PMID20572021.
- ^Ziółkowska NE, Wlodawer A (2006)."Structural studies of algal lectins with anti-HIV activity".Acta Biochimica Polonica.53(4): 617–26.doi:10.18388/abp.2006_3290.PMID17128290.
- ^Li Y, Zhang X, Chen G, Wei D, Chen F (2008). "Algal lectins for potential prevention of HIV transmission".Current Medicinal Chemistry.15(11): 1096–104.doi:10.2174/092986708784221421.PMID18473805.
- ^Garrison AR, Giomarelli BG, Lear-Rooney CM, Saucedo CJ, Yellayi S, Krumpe LR, Rose M, Paragas J, Bray M, Olinger GG, McMahon JB, Huggins J, O'Keefe BR (December 2014)."The cyanobacterial lectin scytovirin displays potent in vitro and in vivo activity against Zaire Ebola virus".Antiviral Research.112:1–7.doi:10.1016/j.antiviral.2014.09.012.PMC4258435.PMID25265598.
- ^Barton C, Kouokam JC, Lasnik AB, Foreman O, Cambon A, Brock G, Montefiori DC, Vojdani F, McCormick AA, O'Keefe BR, Palmer KE (2014)."Activity of and effect of subcutaneous treatment with the broad-spectrum antiviral lectin griffithsin in two laboratory rodent models".Antimicrobial Agents and Chemotherapy.58(1): 120–7.doi:10.1128/AAC.01407-13.PMC3910741.PMID24145548.
- ^Huskens D, Schols D (July 2012)."Algal lectins as potential HIV microbicide candidates".Marine Drugs.10(7): 1476–97.doi:10.3390/md10071476.PMC3407925.PMID22851920.
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