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Sigma-Aldrich

From Wikipedia, the free encyclopedia
Merck / MilliporeSigma
Company typesubsidiaryofMerck KGaA
Nasdaq:SIAL
Industrychemistry and biotechnology
FoundedAugust 1975
HeadquartersBurlington, Massachusetts,United States[2]
Key people
Matthias Heinzel(Life Science CEO)
Productslife science technologies and specialty chemicals
RevenueEUR€ 6.86 billion (2020)[3]
Number of employees
more than 20,000
ParentMerck KGaA(100%)[4]
Websitewww.sigmaaldrich.com

Sigma-Aldrich(formallyMilliporeSigma)[5][6]is an American chemical,life science,andbiotechnologycompany owned by the multinational chemical conglomerateMerck Group

Sigma-Aldrich was created in 1975 by themergerof Sigma Chemical Company and Aldrich Chemical Company. It grew through various acquisitions until it had over 9,600 employees and was listed on theFortune 1000.The company has two United States headquarters, inSt. LouisandBurlington, MAand has operations in approximately 40 countries.[7]

In 2015, the multinational chemical conglomerate Merck Group acquired Sigma-Aldrich for $17 billion.[8]The company is currently a part of Merck's life science business and in combination with Merck's earlier acquiredMillipore,operates asMilliporeSigma.[5][6]It is headquartered in Burlington, Massachusetts, United States.[2]

History

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Sigma Chemical Company ofSt. Louisand Aldrich Chemical Company ofMilwaukeewere both American specialty chemical companies when they merged in August 1975. The company grew throughout the 1980s and 1990s, with significant expansion in facilities, acquisitions and diversification into new market sectors.[citation needed]

Early history

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  • 1935 – Midwest Consultants was founded inSt Louisby brothers Aaron Fischer and Bernard Fischlowitz, who hired chemical engineer Daniel Broida.[9]
    • 1946 – Sigma was formed from Midwest Consultants and manufactured justadenosine triphosphate.They were the first to manufacture pure ATP.[10]
    • 1972 – Sigma's IPO[11]
  • 1951 – Aldrich founded inMilwaukeebyAlfred Baderand Jack Eisendrath and manufactured just1-methyl-3-nitro-1-nitrosoguanidine.
    • 1966 – Aldrich's IPO[12]
    • 1972 – Subsidiary Aldrich-Boranes launched to manufacture hydroboration products
  • 1975 – Merger of Sigma Chemical and Aldrich Chemical to created Sigma-Aldrich.[13]Their first year earned $43 million in sales.[14]
  • 1999 – Sigma-Aldrich reaches $1 billion in sales
  • 2005 – Announced membership inThe RNAi Consortium[15]
  • 2014 –Merck KGaAannounced that it would purchase Sigma-Aldrich for approx. $17 billion (€13.1 billion).[16][17]
  • November 3, 2014 – Sigma-Aldrich filed a definitive proxy statement with the U.S.Securities and Exchange Commissionto hold a special investors meeting regarding approval for the sale to Merck KGaA.[18]

Acquisitions

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1970s

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  • 1978 – Makor Chemicals

1980s

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  • 1984 – Pathfinder
  • 1986 – Bio Yeda, Bristol Organics
  • 1989 – Fluka Chemie AG (Swiss company founded in the 1950s) purchased for $39 million.

1990s

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  • 1993 – Supelco, Inc. acquired to enter the chromatography market
  • 1994 – LabKemi AB
  • 1997 – Research Biochemicals International, Riedel-de-Haen, Techcares Systems, Carbolabs, YA Kemia
  • 1998 – Genosys

2000s

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  • 2000 – First Medical Inc., Amelung GmbH, ARK Scientific
  • 2001 – ISOTEC (produces stable isotopes used in basic research and medical diagnostics)[19]
  • 2004 – Ultrafine (a supplier of contract manufacturing services for drug development), Tetrionics (a producer of high potency and cytotoxic active pharmaceutical ingredients)[20]
  • 2005 – JRH Biosciences,[21]an industrial supplier of cell culture products for the pharmaceutical and biotechnology industries; Proligo Group, a global supplier of genomics research tools
  • 2006 – Beijing Superior Chemicals,[22]Iropharm, Pharmorphix,[23]Advanced Separation Technologies[24](manufacturer of products forchiral chromatography)
  • 2007 – Epichem[25]acquired to expand capabilities in materials sciences and semiconductor markets; Molecular Medicine BioServices acquired to provide large-scale viral manufacturing capabilities; announced alliance with Sangamo BioSciences to develop zinc finger-based laboratory research reagents
  • 2009 – ChemNavigator
  • 2010 – Cerilliant Corporation, ACE Animals
  • 2011 – Resource Technology Corp, Vetec Quimica Fina
  • 2012 – Research Organics Inc., BioReliance (a toxicology and veterinary diagnostics company);[26]BioReliance had previously been acquired byInvitrogenand subsequently sold toAvista Capital Partners.[27]
  • 2014 – Cell Marque[28]
  • 2015 – Combined with EMD Millipore to make MilliporeSigma.[citation needed]

Key numbers

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Key numbers for Sigma-Aldrich.[29]

Revenues:[30]

  • $2.79 billion (2014)

Products:

  • 100,000 chemical products (46,000 manufactured)
  • 30,000 laboratory equipment products

Customers:

  • Approximately one million individual customers worldwide
  • 88,000 accounts

Geographies (% of 2008 sales):

  • United States 35%
  • Europe 43%
  • Canada, Asia Pacific, Latin America 22%

Subsidiaries

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The Aldrich Logo.

Aldrichis a supplier in the research andfine chemicalsmarket. Aldrich providesorganicandinorganic chemicals,building blocks,reagents,advanced materials and stableisotopesforchemical synthesis,medicinalchemistryandmaterials science.Aldrich's chemicals catalog, the "Aldrich Catalog and Handbook" is often used as ahandbookdue to the inclusion ofstructures,physical data,and literaturereferences.

The Sigma Logo.

Sigmais the Sigma-Aldrich's main biochemical supplier, with offerings includingantibiotics,buffers,carbohydrates,enzymes,forensic tools,hematologyandhistology,nucleotides,proteins,peptides,amino acidsand their derivatives.

The Sigma RBI Logo.

Sigma RBIproduces specialized products for use in the field ofcell signalingandneuroscience.Their offerings range from standard biochemical reagents to specialized research tools, includingligandsforreceptorsandion channels,enzyme inhibitors,phosphospecificantibodies,key signal transduction enzymes, andassaykits for cell signaling.

The ISOTEC Logo.

ISOTECprovidesisotopicallylabeled products forprotein structuredetermination,peptide synthesis,proteomics,metabolicresearch,magnetic resonance imaging,nuclear magnetic resonance,breath testsubstrates,agriculture,as well asgasand gas mixes.

The Riedel-de Haën Logo.

Riedel-de Haënwas incorporated with Sigma-Aldrich in 1999 and manufactures reagents and standards.

The Supelco Logo.

Supelcois thechromatographyproducts branch of Sigma-Aldrich. It provideschromatographycolumns and related tools forenvironmental,government,food and beverage,pharmaceutical,biotechnology,medicalandchemicallaboratories; sample preparation products and chemical reference standards.

The SAFC Logo.

Sigma-Aldrich Fine Chemicals (SAFC)is the fine chemical supply branch of Sigma-Aldrich specializing in raw materials forcell cultureproducts; customized services for raw materials, manufacturing of activepharmaceuticalingredients.

Sigma Life Scienceprovides products such as customDNA/RNAoligos;custom DNA andLNAprobes;siRNA;isotopically-labelled peptides and peptide libraries.

Sigma Advanced Genetic Engineering(SAGE) Labs is a division within Sigma-Aldrich that specializes ingenetic manipulationof in vivo systems for special research and development applications. It was formed in 2008 to investigatezinc finger nucleasetechnology and its application for disease research models. Located in St. Louis, Missouri, SAGE Labs have developedknockout ratsfor the study of human diseases and disorders (such as autism), which are sold for up to US$95,000. SAGE also announced its first successful effort in creating a "knockout rabbit".[31]Its facilities include a specific pathogen free, biosecurevivariumas well as research and development labs.

Carbolabsproduces research quantities of chemicals produced byphosgenationreactions. The company was acquired in 1998.[32]

BioRelianceprovides testing and manufacturing services to pharmaceutical and biopharmaceutical companies that span the product cycle from early pre-clinical development to licensed production. The company was acquired by Sigma Aldrich in January 2012.

Current leadership

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Matthias Heinzel became CEO of the Life Science business of Merck KGaA, Darmstadt, Germany in April 2021 following Udit Batra's departure from the company.[33]

References

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  1. ^Vit, Armin (October 15, 2015)."Good Vibrations".Brand New.UnderConsideration.
  2. ^abCarlock, Catherine (January 20, 2021)."MilliporeSigma buys its Burlington HQ for $252M".Boston Business Journal.
  3. ^Annual Report 2020(PDF)(Report). EMD Group, part of Merck KGaA. 2020. Archived fromthe original(PDF)on August 13, 2022.
  4. ^"Merck KGaA, Darmstadt, Germany, Completes Sigma-Aldrich Acquisition"(XBRL).Merck. November 18, 2015.
  5. ^ab"Customer Letter".Archived fromthe originalon 2016-02-08.Retrieved2016-01-04.
  6. ^abAbout Us, EMD Millipore + Sigma-Aldrich = MilliporeSigma, The life science business of Merck KGaA, Darmstadt, Germany
  7. ^"Sigma-Aldrich Corporation – Investor Relations".
  8. ^""Sigma-Aldrich, Merck KGaA Press Release, 22 Sept. 2014"(PDF).
  9. ^"80 Humble Beginnings for a Great Company".stltoday.com.3 October 2014.
  10. ^"80 Years Fueling Scientific Discovery".sigmaaldrich.com.
  11. ^"80 Years Fueling Scientific Discovery".sigmaaldrich.com.
  12. ^"80 Years Fueling Scientific Discovery".sigmaaldrich.com.
  13. ^"Funding Universe History of Sigma-Aldrich Corporation".Funding-Universe.
  14. ^"80 Years Fueling Scientific Discovery".sigmaaldrich.com.
  15. ^"NCBI on Sigma-Aldrich".
  16. ^Ludwig Burger (September 22, 2014)."Germany's Merck to buy Sigma-Aldrich for $17 billion to boost lab supplies operation".Reuters.RetrievedSeptember 23,2014.
  17. ^Staff (October 15, 2014). "Merck KGaA to Acquire Sigma-Aldrich for $17B".Genetic Engineering & Biotechnology News.p. 10.
  18. ^"Sigma-Aldrich Corporation Announces Filing Of Definitive Proxy Statement And Date Of Special Meeting Of Stockholders".Acquire Media. Archived fromthe originalon December 28, 2014.Retrieved3 November2014.
  19. ^"Sigma-Aldrich Corp acquires Isotec Inc from Taiyo Nippon Sanso Corp".
  20. ^"Sigma-Aldrich Corp acquires Ultrafine".
  21. ^"Sigma-Aldrich Corp acquires JRH Biosciences Inc from CSL Ltd".
  22. ^"Sigma-Aldrich Corp acquires Beijing Superior Chem & Instr".
  23. ^"Sigma-Aldrich Corp acquires Pharmorphix Ltd".
  24. ^"Sigma-Aldrich Corp acquires Advanced Separation Tech Inc from Calgon Carbon Corp".
  25. ^"Sigma-Aldrich Corp acquires Epichem Group Ltd".
  26. ^"Sigma-Aldrich to buy BioReliance Hldgs for $350M",News,Bioscience Technology,Associated Press, 9 Jan 2012,retrieved11 Jan2012
  27. ^Invitrogen Completes Divestiture of BioReliance(press release),Life Technologies,12 April 2007, archived fromthe originalon 2012-03-30,retrieved11 Jan2012
  28. ^"80 Years Fueling Scientific Discovery".sigmaaldrich.com.
  29. ^"SIGMA ALDRICH CORP (10-K), Consolidated Statements of Income"(XBRL).United States Securities and Exchange Commission. February 12, 2015.
  30. ^"Sigma-Aldrich Corporate Fact Sheet"(PDF).
  31. ^"SAGE's Latest Knockout: $95,000 Lab Rats".Fast Company.
  32. ^"Carbolabs purchased".ICIS.
  33. ^"Executive board changes at Germany's Merck".www.thepharmaletter.com.Retrieved2021-04-02.
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