Sign of Hertoghe
| Sign of Hertoghe | |
|---|---|
| Other names | Queen Anne's sign |
 | |
| Anne of Denmark mourning the death of her son Henry in 1612 | |
| Differential diagnosis | hypothyroidism |
TheSign of HertogheorQueen Anne's signis a thinning or loss of the outer third of the eyebrows, and is a classical sign ofhypothyroidismoratopic dermatitis,[1][2][3]but it can also be detected inlepromatous leprosy.[4]The sign is named after the Belgian Internist Eugene Ludovic Christian Hertoghe (April 5, 1860–January 3, 1928), who was a native ofAntwerp,and was the first pioneer inthyroidfunction research.[2][3][5]
Queen Anne's sign[edit]
The association withAnne of Denmarkis based on portraiture, although history does not suggest that she suffered an underactive thyroid.[6]Theeponymis disputed by some, though it has been suggested thatAnne of France,Anne of Brittany,Anne of Austria,Anne BoleynandAnne of Clevesmay all be eliminated as candidates.[7]
References[edit]
- ^Ständer, Sonja (2021-03-25). "Atopic Dermatitis".New England Journal of Medicine.384(12): 1136–1143.doi:10.1056/NEJMra2023911.PMID33761208.S2CID232355341.
- ^abSchatz, Henry A. (May 1922). "The Role of the Thyroid Gland in Otolaryngology".The Pennsylvania Medical Journal.25(8): 529.
- ^ab"Complimentary Dinner given by Dr. William Seaman Bainbridge".American Medicine.9(4): 308. April 1914.Retrieved2014-12-12.
- ^Parrino, Daniela; Di Bella, Stefano (2016-03-29)."Hertoghe sign: an hallmark of lepromatous leprosy".QJM: Monthly Journal of the Association of Physicians.109(7): 497.doi:10.1093/qjmed/hcw046.ISSN1460-2393.PMID27026695.
- ^"Eugène Ludovic Christian Hertoghe (1860-1928) » van Lerberghe genealogy » Genealogy Online".
- ^Lane Furdell E (May 2007)."Eponymous, anonymous: Queen Anne's sign and the misnaming of a symptom".J Med Biogr.15(2): 97–101.doi:10.1258/j.jmb.2007.06-13.PMID17551609.S2CID2474437.
- ^Keynes, M (February 2009)."Letter to the editor".J Med Biogr.17(1): 62.doi:10.1258/jmb.2007.007021.PMID19190203.S2CID207200169.