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Simeticone

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Simeticone
Clinical data
Trade namesInfacol, Wind-eze, WindSetlers, many others
Other namessimethicone[1](USANUS)
AHFS/Drugs.comMonograph
Pregnancy
category
  • C
Routes of
administration		Oral
ATC code
Legal status
Legal status
Pharmacokineticdata
BioavailabilityNone
Protein binding0%
MetabolismNot metabolized
Eliminationhalf-lifeN/A
ExcretionFeces
Identifiers
  • Poly(dimethylsiloxane), silicon dioxide
CAS Number
PubChemCID
DrugBank
ChemSpider
  • None
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.107.016Edit this at Wikidata
Chemical and physical data
Formula(C2H6OSi)n· (SiO2)m
Molar massVariable
☒NcheckY(what is this?)(verify)

Simeticone(INN), also known assimethicone(USAN), is ananti-foaming agentused to reducebloating,discomfort or pain caused by excessive gas.

Medical uses

[edit]
Simethicone tablets

Simeticone is used to relieve the symptoms of excessive gas in thegastrointestinal tract,namely bloating, burping, and flatulence.[2][3]While there is a lack of conclusive evidence that simeticone is effective for this use,⁣[4][5][failed verification]studies have shown that it can relieve symptoms offunctional dyspepsia[6]andfunctional bloating.[7]

It has not been fully established that simeticone is useful to treatcolicin babies,[8]and it is not recommended for this purpose.[5]A study in the United Kingdom reported that according to parental perception simeticone helped infant colic in some cases.[9]

Simeticone can also be used for suspectedpostoperativeabdominal discomfortin infants.[10]

Side effects

[edit]

Simeticone does not have any serious side effects.[11]Two uncommon side effects (occurring in 1 in 100 to 1 in 1,000 patients) are constipation and nausea.[12]

Pharmacology

[edit]

Simeticone is a non-systemicsurfactantwhich decreases the surface tension of gas bubbles in the GI tract.[11]This allows gas bubbles to leave the GI tract asflatulenceorbelching.[11]Simeticone does not reduce or prevent the formation of gas.[13]Its effectiveness has been shown in severalin vitrostudies.[14][15]

Chemistry

[edit]

Simeticone is a mixture ofdimethiconeandsilicon dioxide.[16]

Names

[edit]

The INN name is "simeticone", which was added to the INN recommended list in 1999.[17]

Simeticone is marketed under many brand names and in manycombination drugs;it is also marketed as a veterinary drug.[18]

Brands

Brand names include A.F., Acid Off, Aero Red, Aero-OM, Aero-Sim, Aerocol, Aerox, Aesim, Aflat, Air-X, Anaflat, Antiflat, Baby Rest, Bicarsim, Bicarsim Forte, Blow-X, Bobotic, Bobotik, Carbogasol, Colic E, Colin, Cuplaton, Degas, Dentinox, Dermatix, Digesta, Dimetikon Meda, Disflatyl, Disolgas, Elugan N, Elzym, Endo-Paractol, Enterosilicona, Espaven Antigas, Espumisan, Espumisan L, Flacol, Flapex, Flatidyl, Flatoril, Flatulex, Flucolic, Gas X, Gas-X, Gaselab, Gaseoflat, Gaseoflatex, Gaseophar, Gaseoplus, Gaseovet, Gaservol, Gasimetin, Gasnil, Gasofilm, Gastrex, Gastrosen, Gazim X, Gazix, Geludrox-HS, Genasyme, Ilio-Funkton, Imogas, Imogaze, Imonogas, Infacalm, Infacol, Infacolic, Lefax, Lefaxin, Lefoam, Logastin, Luftal, Maxi Flat, Meteosim, Metiorisan, Metsil, Mylanta, Mylicon, Mylicongas, Mylom, Mymus, Nanog, Neodrop, Neogasol, Neolanta, Orocure, Ovol, Pedicon, Phazin, Phazyme, Restime, Rugby Gas Relief, Sab Simplex, Salinal, Semecon, Semeth, Sicongast, Siflat, Silbione, Siligas, Silipin, Sim, Simcone, Simecon, Simecrin, Simedill, Simegut, Simet, Simethicon, Simethicone, Simetic, Simeticon, Simeticona, Simeticone, Siméticone, Simeticonum, Simetigast, Simflat, Simicol, Simicon, Wilcon, Wind-eze and WindSetlers.[18]

It is also marketed as acombination drug:[18]

  • withalgeldrateas Kestomatine
  • withaluminiumormagnesiumsalts and in some cases both, as Alamag Plus, Almacone, Alposim, Aluphagel, Alutop, Amico-L Andursil, Axcel Eviline, Boots Wind Relief, Di-Gel, Diovol Plus, Diovol Plus AF, Gas Ban DS, Hydrosil, Iosopan Plus, Kremil, Kremil-S, Maalox Plus, Mi-Acid, Mygel, Mylagen, Polysilane Delalande, Rumibex and Trial AG
  • withalverineas Avarin, Meteospasmyl, Nady-Spasmyl
  • withbarium sulfateas Bario Dif
  • withbismuthas Gastop
  • withcalcium carbonateas Flamints, Gaseoflatex Plus, Malugel, Titralac Plus
  • withactivated charcoalas Carbosylane, Clingest, Finigax. Flatuna
  • withcinitaprideas Rogastril Plus
  • withcleboprideas Flatoril
  • withdicycloverineas Cloact, Colicspam, Colimix, Colispas, Coliza-D, Cyclopam, Fri-Spas, Meftal Spas, Respas, Simcomine, Spasact, Spasmindon DPS
  • withdomperidoneas Bigetric, Dom Simecon, Doprokin-S, Glomoti, Moperidona AF, Mutecium, Praxis
  • withhydrotalciteas Altacide and Talsil Forte
  • withhomatropineas Aero-Sim Compuesto, Asestor, Factor AG, Sedotropina Flat
  • withlactuloseas Dinolak
  • withlevonorgestrelas Jaydess
  • withloperamideas Eldoper Plus, Imodium Duo, Imolopesim, Loperamide HCl/Dimeticon, Loperuma, Lositala, Losiwuto, Regulane AF, Stoperan Plus, Toban F Plus
  • withmagaldrateas Aci Basic, Aci-Tip, Acicone-S, Acid-Farvet, Acifin, Amalset, Antiax, Asidrat, Assis, Avicid, Banacid-s, Buenox, Cremalon, Curecid, Digax, Digeril, Endcid, Gaseovet MS, Gastrine, Gastrogel, Gastroral, Gastrorapid, Magacid, Magal-D, Magalat, Magaldrato+Simeticona, Magaldrax, Maganta Plus, Magsilon, Marlox Plus, Megacil Plus, Megalrat Plus, Minicidez, Miopan Plus, Novelta, Oxecone-MS, Riopan Plus, Rolac Plus, Sedo Mag, Simagal, Simelgat Plus, Taimacon, Zymcon
  • withmetoclopramideas Anaflat Compuesto, Di-Aero OM, Digespar, Factorine, Pangastren
  • withmosaprideas M-Pride-MPS, Moxar, Moza MPS
  • withpancreatinas Anaflat Enzimático, Digenil, Digesflat, Enzym Lefax, Enzymet, Enzymin, fermento duodenal, Finigax Indigestion, Flaton, Flazymec, Gasflat, Gaszym, Gesdyp, Hazmolin, Komflat, MeteoZym, Pankreoflat, Tripanzym
  • withpapaverineas Espasmo Siligas
  • withpinaveriumas Alevian Duo, Pladuet, Planex
  • withpipenzolate bromideas Cadinol, Gasorbol Gotas
  • withphloroglucinolas Meteoxane
  • withtrimebutineas Eumotil-S, Eumotrix Plus, Libertrim SDP, Libertrim SII, Muvett S
  • withureaas Hidribet.

It is also marketed as a veterinary drug under the brands Birp and Methysilox.

References

[edit]
  1. ^"Simethicone names".Drugs.com.Retrieved27 August2017.
  2. ^"Simethicone tablet".NIH DailyMed. April 2016.Retrieved27 August2017.
  3. ^"Simeticone".NHS.10 October 2019.Retrieved30 January2020.
  4. ^Modi R, Clearfield HR, Levitt M (July 2013)."Belching, Bloating and Flatulence".American College of Gastroenterology.
  5. ^ab"Simethicone".drugs.com.Efficacy not established for the symptomatic relief of immediate postprandial upper abdominal distress
  6. ^Holtmann G, Gschossmann J, Mayr P, Talley NJ (September 2002). "A randomized placebo-controlled trial of simethicone and cisapride for the treatment of patients with functional dyspepsia".Alimentary Pharmacology & Therapeutics.16(9). Wiley: 1641–8.doi:10.1046/j.1365-2036.2002.01322.x.PMID12197843.S2CID23286985.
  7. ^Burta O, Iacobescu C, Mateescu RB, Nicolaie T, Tiuca N, Pop CS (25 September 2018)."Efficacy and safety of APT036 versus simethicone in the treatment of functional bloating: a multicentre, randomised, double-blind, parallel group, clinical study".Translational Gastroenterology and Hepatology.3(72). AME Publications: 72.doi:10.21037/tgh.2018.09.11.PMC6256934.PMID30511026.
  8. ^Biagioli E, Tarasco V, Lingua C, Moja L, Savino F (September 2016)."Pain-relieving agents for infantile colic".The Cochrane Database of Systematic Reviews.2016(9): CD009999.doi:10.1002/14651858.CD009999.pub2.PMC6457752.PMID27631535.
  9. ^Goldman M, Beaumont T (March 2017). "A real world evaluation of a treatment for infant colic based on the experience and perceptions of 4004 parents".British Journal of Nursing.26(5 Suppl 1): S3–S10.doi:10.12968/bjon.2017.26.Sup5.S3.PMID28350192.S2CID32885530.
  10. ^Voepel-Lewis TD, Malviya S, Burke C, D'Agostino R, Hadden SM, Siewert M, Tait AR (March 1998). "Evaluation of simethicone for the treatment of postoperative abdominal discomfort in infants".Journal of Clinical Anesthesia.10(2): 91–94.doi:10.1016/S0952-8180(97)00249-3.PMID9524891.
  11. ^abcIngold CJ, Akhondi H (January 2021)."Simethicone".StatPearls [Internet].PMID32310457.
  12. ^"Simethicone Side Effects in Detail".Drugs.com.Retrieved27 August2017.
  13. ^"Treatment of Gas".International Foundation for Functional Gastrointestinal Disorders. 4 September 2015.
  14. ^Brecević L, Bosan-Kilibarda I, Strajnar F (May 1994)."Mechanism of antifoaming action of simethicone".Journal of Applied Toxicology.14(3). Wiley: 207–11.doi:10.1002/jat.2550140311.PMID8083482.S2CID7453218.Retrieved30 January2020.
  15. ^Dittrich M, Miederer SE, Havertz B, Krastev R (12 May 2010)."Schaumzerstörung und Schaumverhinderung: Der Wirkmechanismus von Simeticon in vitro"[Defoaming and antifoaming action of simethicone in vitro](PDF).Journal für Gastroenterologische und Hepatologische Erkrankungen.(in German).8(3). Krause & Pachernegg: 19–25.
  16. ^O'Neil MJ, ed. (2006). "Dimethicone".The Merck Index(14th ed.). Whitehouse Station, NJ: Merck. p. 545.
  17. ^"Recommended INN List 42"(PDF).WHO Drug Information.13(3): 202. 1999.
  18. ^abc"Simeticone international brands".Drugs.com.Retrieved27 August2017.
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