Sodium citrate

Sodium citratemay refer to any of thesodium saltsofcitric acid(though most commonly the third):

The three forms of salt are collectively known by theE numberE331.

Applications[edit]

Food[edit]

Sodium citrates are used as acidity regulators in food and drinks, and also asemulsifiersfor oils. They enable cheeses to melt without becoming greasy. It reduces the acidity of food as well. It is generally considered safe and is considered GRAS by the FDA.^[1]

Blood clotting inhibitor[edit]

Sodium citrate is used to preventdonated bloodfrom clotting in storage. It is also used in a laboratory, before an operation, to determine whether a person's blood is too thick and might cause a blood clot, or if the blood is too thin to safely operate. Sodium citrate is used in medical contexts as analkalinizing agentin place ofsodium bicarbonate,^[2]to neutralize excess acid in the blood and urine.^[3]

Metabolic acidosis[edit]

It has applications for the treatment ofmetabolic acidosis^[4]andchronic kidney disease.^[5]

Ferrous nanoparticles[edit]

Along witholeic acid,sodium citrate may be used in the synthesis ofmagnetic Fe₃O₄ nanoparticlecoatings.^[6]

References[edit]

^"FDA: GRAS".
^"dRTA: How is it Treated?".National Kidney Foundation.2019-06-07.Retrieved2021-08-02.
^PubChem."Sodium citrate".pubchem.ncbi.nlm.nih.gov.Retrieved2021-08-02.
^Chen, Wei; Abramowitz, Matthew K. (February 2014)."Treatment of Metabolic Acidosis in Patients With CKD".American Journal of Kidney Diseases.63(2): 311–317.doi:10.1053/j.ajkd.2013.06.017.ISSN 0272-6386.PMC3946919.PMID 23932089.
^Goraya, Nimrit; Wesson, Donald E. (May 2019)."Clinical evidence that treatment of metabolic acidosis slows the progression of chronic kidney disease".Current Opinion in Nephrology and Hypertension.28(3): 267–277.doi:10.1097/MNH.0000000000000491.ISSN 1062-4821.PMC6467553.PMID 30681417.
^Wei, Yan; Han, Bing; Hu, Xiaoyang; Lin, Yuanhua; Wang, Xinzhi; Deng, Xuliang (2012)."Synthesis of Fe3O4 Nanoparticles and their Magnetic Properties".Procedia Engineering.27:632–637.arXiv:2001.06583.doi:10.1016/j.proeng.2011.12.498.

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[1] "FDA: GRAS".

[2] "dRTA: How is it Treated?".National Kidney Foundation.2019-06-07.Retrieved2021-08-02.

[3] PubChem."Sodium citrate".pubchem.ncbi.nlm.nih.gov.Retrieved2021-08-02.

[4] Chen, Wei; Abramowitz, Matthew K. (February 2014)."Treatment of Metabolic Acidosis in Patients With CKD".American Journal of Kidney Diseases.63(2): 311–317.doi:10.1053/j.ajkd.2013.06.017.ISSN 0272-6386.PMC3946919.PMID 23932089.

[5] Goraya, Nimrit; Wesson, Donald E. (May 2019)."Clinical evidence that treatment of metabolic acidosis slows the progression of chronic kidney disease".Current Opinion in Nephrology and Hypertension.28(3): 267–277.doi:10.1097/MNH.0000000000000491.ISSN 1062-4821.PMC6467553.PMID 30681417.

[6] Wei, Yan; Han, Bing; Hu, Xiaoyang; Lin, Yuanhua; Wang, Xinzhi; Deng, Xuliang (2012)."Synthesis of Fe3O4 Nanoparticles and their Magnetic Properties".Procedia Engineering.27:632–637.arXiv:2001.06583.doi:10.1016/j.proeng.2011.12.498.

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