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Gastroenteritis
Other namesGastro, stomach bug, stomach virus, stomach flu, gastric flu, gastrointestinitis, flu bug
Gastroenteritis viruses: A = rotavirus, B = adenovirus, C = norovirus and D = astrovirus. The virus particles are shown at the same magnification to allow size comparison.
SpecialtyInfectious disease,gastroenterology
SymptomsDiarrhea,vomiting,abdominalpain,fever[1][2]
ComplicationsDehydration[2][3]
CausesViruses,bacteria,parasites,fungus[2][4]
Diagnostic methodBased on symptoms, occasionallystool culture[2]
Differential diagnosisInflammatory bowel disease,malabsorption syndrome,lactose intolerance[5]
PreventionHand washing,drinkingclean water,proper disposal ofhuman waste,breastfeeding[2]
TreatmentOral rehydration solution(combination of water, salts, and sugar),intravenous fluids[2]
Frequency2.4 billion (2015)[6]
Deaths1.3 million (2015)[7]

Gastroenteritis,also known asinfectious diarrhea,is aninflammationof thegastrointestinal tractincluding thestomachandintestine.[8]Symptoms may includediarrhea,vomiting,andabdominal pain.[1]Fever,lack of energy, anddehydrationmay also occur.[2][3]This typically lasts less than two weeks.[8]Although it is not related toinfluenza,in the U.S. and U.K., it is sometimes called the "stomach flu".[9]

Gastroenteritis is usually caused byviruses;[4]however, gutbacteria,parasites,andfungican also cause gastroenteritis.[2][4]In children,rotavirusis the most common cause of severe disease.[10]In adults,norovirusandCampylobacterare common causes.[11][12]Eating improperly prepared food, drinking contaminated water or close contact with a person who is infected canspread the disease.[2]Treatment is generally the same with or without a definitive diagnosis, so testing to confirm is usually not needed.[2]

For young children in impoverished countries, prevention includeshand washingwith soap, drinkingclean water,breastfeedingbabies instead of usingformula,[2]and proper disposal ofhuman waste.Therotavirus vaccineis recommended as a prevention for children.[2][10]Treatment involves getting enough fluids.[2]For mild or moderate cases, this can typically be achieved by drinkingoral rehydration solution(a combination of water, salts and sugar).[2]In those who are breastfed, continued breastfeeding is recommended.[2]For more severe cases,intravenous fluidsmay be needed.[2]Fluids may also be given by anasogastric tube.[13]Zincsupplementation is recommended in children.[2]Antibioticsare generally not needed.[14]However, antibiotics are recommended for young children with a fever and bloody diarrhea.[1]

In 2015, there were two billion cases of gastroenteritis, resulting in 1.3 million deaths globally.[6][7]Children and those in thedeveloping worldare affected the most.[15]In 2011, there were about 1.7 billion cases, resulting in about 700,000 deaths of children under the age of five.[16]In the developing world, children less than two years of age frequently get six or more infections a year.[17]It is less common in adults, partly due to the development ofimmunity.[18]

Signs and symptoms

[edit]
Bristol stool chart

Gastroenteritis usually involves bothdiarrheaandvomiting.[18]Sometimes, only one or the other is present.[1]This may be accompanied by abdominal cramps.[1]Signs and symptoms usually begin 12–72 hours after contracting the infectious agent.[15]If due to a virus, the condition usually resolves within one week.[18]Some viral infections also involvefever,fatigue,headacheandmuscle pain.[18]If thestool is bloody,the cause is less likely to be viral[18]and more likely to be bacterial.[19]Some bacterial infections cause severe abdominal pain and may persist for several weeks.[19]

Children infected with rotavirus usually make a full recovery within three to eight days.[20]However, in poor countries treatment for severe infections is often out of reach and persistent diarrhea is common.[21]Dehydrationis a common complication ofdiarrhea.[22]Severe dehydration in children may be recognized if the skin color and position returns slowly when pressed.[23]This is called "prolongedcapillary refill"and" poorskin turgor".[23]Abnormal breathing is another sign of severe dehydration.[23]Repeat infections are typically seen in areas with poor sanitation, andmalnutrition.[15]Stunted growthand long-term cognitive delays can result.[17]

Reactive arthritisoccurs in 1% of people following infections withCampylobacterspecies.[19]Guillain–Barré syndromeoccurs in 0.1%.[19]Hemolytic uremic syndrome(HUS) may occur due to infection withShiga toxin-producingEscherichia coliorShigellaspecies.[24]HUS causeslow platelet counts,poor kidney function,andlow red blood cell count (due to their breakdown).[24]Children are more predisposed to getting HUS than adults.[17]Some viral infections may producebenign infantile seizures.[1]

Cause

[edit]

Viruses(particularlyrotavirus(in children) andnorovirus(in adults)) and the bacteriaEscherichia coliandCampylobacterspecies are the primary causes of gastroenteritis.[15][25]There are, however, many other infectious agents that can cause this syndrome includingparasitesandfungus.[17][4]Non-infectious causes are seen on occasion, but they are less likely than a viral or bacterial cause.[1]Risk of infection is higher in children due to their lack ofimmunity.[1]Children are also at higher risk because they are less likely to practice goodhygienehabits.[1]Children living in areas without easyaccess to water and soapare especially vulnerable.[1]

Viral

[edit]

Rotaviruses,noroviruses,adenoviruses,andastrovirusesare known to cause viral gastroenteritis.[26]Rotavirus is the most common cause of gastroenteritis in children,[25]and produces similar rates in both thedevelopedanddeveloping world.[20]Viruses cause about 70% of episodes of infectious diarrhea in the pediatric age group.[13]Rotavirus is a less common cause in adults due to acquired immunity.[27]Norovirus is the cause in about 18% of all cases.[28]Generally speaking, viral gastroenteritis accounts for 21–40% of the cases of infectious diarrhea in developed countries.[29]

Norovirus is the leading cause of gastroenteritis among adults in America accounting for about 90% of viral gastroenteritis outbreaks.[18]These localizedepidemicstypically occur when groups of people spend time proximate to each other, such as oncruise ships,[18]in hospitals, or in restaurants.[1]People may remain infectious even after their diarrhea has ended.[18]Norovirus is the cause of about 10% of cases in children.[1]

Bacterial

[edit]
Salmonella entericaserovar Typhimurium (ATCC 14028) as seen with a microscope at 1000 fold magnification and following Gram staining

In some countries,Campylobacter jejuniis the primary cause of bacterial gastroenteritis, with half of these cases associated with exposure topoultry.[19]In children, bacteria are the cause in about 15% of cases, with the most common types beingEscherichia coli,Salmonella,Shigella,andCampylobacterspecies.[13]If food becomes contaminated with bacteria and remains at room temperature for a period of several hours, the bacteria multiply and increase the risk of infection in those who consume the food.[17]Some foods commonly associated with illness include raw or undercooked meat, poultry, seafood, and eggs; raw sprouts; unpasteurized milk and soft cheeses; and fruit and vegetable juices.[30]In the developing world, especially sub-Saharan Africa and Asia,cholerais a common cause of gastroenteritis. This infection is usually transmitted by contaminated water or food.[31]

ToxigenicClostridium difficileis an important cause of diarrhea that occurs more often in the elderly.[17]Infants can carry these bacteria without developing symptoms.[17]It is a common cause of diarrhea in those who are hospitalized and is frequently associated with antibiotic use.[32]Staphylococcus aureusinfectious diarrhea may also occur in those who have used antibiotics.[33]Acute "traveler's diarrhea"is usually a type of bacterial gastroenteritis, while the persistent form is usually parasitic.[34]Acid-suppressing medication appears to increase the risk of significant infection after exposure to a number of organisms, includingClostridium difficile,Salmonella,andCampylobacterspecies.[35]The risk is greater in those takingproton pump inhibitorsthan withH2antagonists.[35]

Parasitic

[edit]

A number ofparasitescan cause gastroenteritis.[13]Giardia lambliais most common, butEntamoeba histolytica,Cryptosporidiumspp., and other species have also been implicated.[13][34]As a group, these agents comprise about 10% of cases in children.[24][34]Giardiaoccurs more commonly in the developing world, but this type of illness can occur nearly everywhere.[36]It occurs more commonly in persons who have traveled to areas with high prevalence, children who attendday care,men who have sex with men,and followingdisasters.[36]

Transmission

[edit]

Transmission may occur from drinking contaminated water or when people share personal objects.[15]Water quality typically worsens during the rainy season and outbreaks are more common at this time.[15]Inareas with four seasons,infections are more common in the winter.[17]Worldwide,bottle-feedingof babies with improperly sanitized bottles is a significant cause.[15]Transmission rates are also related to poor hygiene, (especially among children),[18]in crowded households,[37]and in those with poor nutritional status.[17]Adults who have developed immunities might still carry certain organisms without exhibiting symptoms.[17]Thus, adults can becomenatural reservoirsof certain diseases.[17]While some agents (such asShigella) only occur inprimates,others (such asGiardia) may occur in a wide variety of animals.[17]

Non-infectious

[edit]

There are a number of non-infectious causes of inflammation of the gastrointestinal tract.[1]Some of the more common include medications (likeNSAIDs), certain foods such aslactose(in those who are intolerant), andgluten(in those withceliac disease).Crohn's diseaseis also a non-infectious cause of (often severe) gastroenteritis.[1]Disease secondary totoxinsmay also occur. Some food-related conditions associated with nausea, vomiting, and diarrhea include:ciguatera poisoningdue to consumption of contaminated predatory fish,scombroidassociated with the consumption of certain types of spoiled fish,tetrodotoxin poisoningfrom the consumption ofpuffer fishamong others, andbotulismtypically due to improperly preserved food.[38]

In the United States, rates of emergency department use for noninfectious gastroenteritis dropped 30% from 2006 until 2011. Of the twenty most common conditions seen in the emergency department, rates of noninfectious gastroenteritis had the largest decrease in visits in that time period.[39]

Pathophysiology

[edit]

Gastroenteritis is defined asvomitingordiarrheadue to inflammation of thesmallorlarge bowel,often due to infection.[17]The changes in the small bowel are typically noninflammatory, while the ones in the large bowel are inflammatory.[17]The number of pathogens required to cause an infection varies from as few as one (forCryptosporidium) to as many as 108(forVibrio cholerae).[17]

Diagnosis

[edit]

Gastroenteritis is typically diagnosed clinically, based on a person's signs and symptoms.[18]Determining the exact cause is usually not needed as it does not alter the management of the condition.[15]

However,stool culturesshould be performed in those with blood in the stool, those who might have been exposed tofood poisoning,and those who have recently traveled to the developing world.[13]It may also be appropriate in children younger than 5, old people, and those with poor immune function.[40]Diagnostic testing may also be done for surveillance.[18]Ashypoglycemiaoccurs in approximately 10% of infants and young children, measuring serumglucosein this population is recommended.[23]Electrolytesandkidney functionshould also be checked when there is a concern about severe dehydration.[13]

Dehydration

[edit]

A determination of whether or not the person hasdehydrationis an important part of the assessment, with dehydration typically divided into mild (3–5%), moderate (6–9%), and severe (≥10%) cases.[1]In children, the most accurate signs of moderate or severe dehydration are a prolongedcapillary refill,poorskin turgor,and abnormal breathing.[23][41]Other useful findings (when used in combination) include sunken eyes, decreased activity, a lack of tears, and a dry mouth.[1]A normal urinary output and oral fluid intake is reassuring.[23]Laboratory testing is of little clinical benefit in determining the degree of dehydration.[1]Thus the use of urine testing or ultrasounds is generally not needed.[42]

Differential diagnosis

[edit]

Other potential causes of signs and symptoms that mimic those seen in gastroenteritis that need to be ruled out includeappendicitis,volvulus,inflammatory bowel disease,urinary tract infections,anddiabetes mellitus.[13]Pancreatic insufficiency,short bowel syndrome,Whipple's disease,coeliac disease,andlaxativeabuse should also be considered.[43]The differential diagnosis can be complicated somewhat if the person exhibitsonlyvomiting or diarrhea (rather than both).[1]

Appendicitis may present with vomiting, abdominal pain, and a small amount of diarrhea in up to 33% of cases.[1]This is in contrast to the large amount of diarrhea that is typical of gastroenteritis.[1]Infections of the lungsor urinary tract in children may also cause vomiting or diarrhea.[1]Classicaldiabetic ketoacidosis(DKA) presents with abdominal pain, nausea, and vomiting, but without diarrhea.[1]One study found that 17% of children with DKA were initially diagnosed as having gastroenteritis.[1]

Prevention

[edit]
Percentage of rotavirus tests with positive results, by surveillance week, United States, July 2000 – June 2009

Water, sanitation, hygiene

[edit]
Further information:WASH § Health aspects

A supply of easily accessible uncontaminated water and goodsanitationpractices are important for reducing rates of infection and clinically significant gastroenteritis.[17]Personalhygienemeasures (such ashand washingwith soap) have been found to decrease rates of gastroenteritis in both the developing and developed world by as much as 30%.[23]Alcohol-based gels may also be effective.[23]Food or drink that is thought to be contaminated should be avoided.[44] Breastfeedingis important, especially in places with poor hygiene, as is improvement of hygiene generally.[15]Breast milk reduces both the frequency of infections and their duration.[1]

Vaccination

[edit]

Due to both its effectiveness and safety, in 2009 the World Health Organization recommended that therotavirus vaccinebe offered to all children globally.[25][45]Two commercial rotavirus vaccines exist and several more are in development.[45]In Africa and Asia these vaccines reduced severe disease among infants[45]and countries that have put in place national immunization programs have seen a decline in the rates and severity of disease.[46][47]This vaccine may also prevent illness in non-vaccinated children by reducing the number of circulating infections.[48]Since 2000, the implementation of a rotavirus vaccination program in the United States has substantially decreased the number of cases of diarrhea by as much as 80 percent.[49][50][51]The first dose of vaccine should be given to infants between 6 and 15 weeks of age.[25]Theoral cholera vaccinehas been found to be 50–60% effective over two years.[52]

There are a number of vaccines against gastroenteritis in development. For example, vaccines againstShigellaand enterotoxigenicEscherichia coli(ETEC), which are two of the leading bacterial causes of gastroenteritis worldwide.[53][54]

Management

[edit]

Gastroenteritis is usually an acute and self-limiting disease that does not require medication.[22]The preferred treatment in those with mild to moderatedehydrationisoral rehydration therapy(ORT).[24]For children at risk of dehydration from vomiting, taking a single dose of theanti vomitingmedicationmetoclopramideorondansetron,may be helpful,[55]andbutylscopolamineis useful in treatingabdominal pain.[56]

Rehydration

[edit]

The primary treatment of gastroenteritis in both children and adults isrehydration.This is preferably achieved by drinking rehydration solution, althoughintravenousdelivery may be required if there is adecreased level of consciousnessor if dehydration is severe.[57][58]Drinking replacement therapy products made with complex carbohydrates (i.e. those made from wheat or rice) may be superior to those based on simple sugars.[59]Drinks especially high in simple sugars, such assoft drinksand fruit juices, are not recommended in children under five years of age as they mayincreasediarrhea.[22]Plain water may be used if more specific ORT preparations are unavailable or the person is not willing to drink them.[22]Anasogastric tubecan be used in young children to administer fluids if warranted.[13]In those who require intravenous fluids, one to four hours' worth is often sufficient.[60]

Dietary

[edit]

It is recommended that breast-fed infants continue to be nursed in the usual fashion, and that formula-fed infants continue their formula immediately after rehydration with ORT.[61]Lactose-free or lactose-reduced formulas usually are not necessary.[61]Children should continue their usual diet during episodes of diarrhea with the exception that foods high insimple sugarsshould be avoided.[61]TheBRAT diet(bananas, rice, applesauce, toast and tea) is no longer recommended, as it contains insufficient nutrients and has no benefit over normal feeding.[61]

A Cochrane Review from 2020 concludes thatprobioticsmake little or no difference to people who have diarrhea lasting 2 days or longer and that there is no proof that they reduce its duration.[62]They may be useful in preventing and treatingantibiotic associated diarrhea.[63]Fermented milk products (such asyogurt) are similarly beneficial.[64]Zincsupplementation appears to be effective in both treating and preventing diarrhea among children in the developing world.[65]

Antiemetics

[edit]

Antiemeticmedications may be helpful for treating vomiting in children.Ondansetronhas some utility, with a single dose being associated with less need for intravenous fluids, fewer hospitalizations, and decreased vomiting.[55][66][67][68]Metoclopramidemight also be helpful.[68]However, the use of ondansetron might possibly be linked to an increased rate of return to hospital in children.[69]The intravenous preparation of ondansetron may be given orally if clinical judgment warrants.[70]Dimenhydrinate,while reducing vomiting, does not appear to have a significant clinical benefit.[1]

Antibiotics

[edit]

Antibiotics are not usually used for gastroenteritis, although they are sometimes recommended if symptoms are particularly severe[71]or if a susceptible bacterial cause is isolated or suspected.[72]If antibiotics are to be employed, amacrolide(such asazithromycin) is preferred over afluoroquinolonedue to higher rates of resistance to the latter.[19]Pseudomembranous colitis,usually caused by antibiotic use, is managed by discontinuing the causative agent and treating it with eithermetronidazoleorvancomycin.[73]Bacteria and protozoans that are amenable to treatment includeShigella[74]Salmonella typhi,[75]andGiardiaspecies.[36]In those withGiardiaspecies orEntamoeba histolytica,tinidazoletreatment is recommended and superior to metronidazole.[36][76]TheWorld Health Organization(WHO) recommends the use of antibiotics in young children who have both bloody diarrhea and fever.[1]

Antimotility agents

[edit]

Antimotility medication has a theoretical risk of causing complications, and although clinical experience has shown this to be unlikely,[43]these drugs are discouraged in people with bloody diarrhea or diarrhea that is complicated by fever.[77]Loperamide,anopioidanalogue, is commonly used for the symptomatic treatment of diarrhea.[78]Loperamide is not recommended in children, however, as it may cross the immature blood–brain barrier and cause toxicity.Bismuth subsalicylate,an insoluble complex of trivalentbismuthand salicylate, can be used in mild to moderate cases,[43]butsalicylate toxicityis theoretically possible.[1]

Epidemiology

[edit]
Deaths due to diarrhoeal diseases per million persons in 2012
0–2
3–10
11–18
19–30
31–46
47–80
81–221
222–450
451–606
607–1799
Disability-adjusted life yearfor diarrhea per 100,000 inhabitants in 2004

It is estimated that there were two billion cases of gastroenteritis that resulted in 1.3 million deaths globally in 2015.[6][7]Children and those in thedeveloping worldare most commonly affected.[15]As of 2011, in those younger than five, there were about 1.7 billion cases resulting in 0.7 million deaths,[16]with most of these occurring in the world's poorest nations.[17]More than 450,000 of these fatalities are due to rotavirus in children under five years of age.[10][79]Choleracauses about three to five million cases of disease and kills approximately 100,000 people yearly.[31]In the developing world, children less than two years of age frequently get six or more infections a year that result in significant gastroenteritis.[17]It is less common in adults, partly due to the development of acquiredimmunity.[18]

In 1980, gastroenteritis from all causes caused 4.6 million deaths in children, with the majority occurring in the developing world.[73]Death rates were reduced significantly (to approximately 1.5 million deaths annually) by 2000, largely due to the introduction and widespread use oforal rehydration therapy.[80]In the US, infections causing gastroenteritis are the second most common infection (after thecommon cold), and they result in between 200 and 375 million cases of acute diarrhea[17][18]and approximately ten thousand deaths annually,[17]with 150 to 300 of these deaths in children less than five years of age.[1]

Society and culture

[edit]

Gastroenteritis is associated with many colloquial names, including "Montezuma's revenge","Delhi belly "," la turista ", and" back door sprint ", among others.[17]It has played a role in many military campaigns and is believed to be the origin of the term "no guts no glory".[17]

Gastroenteritis is the main reason for 3.7 million visits to physicians a year in the United States[1]and 3 million visits in France.[81]In the United States gastroenteritis as a whole is believed to result in costs of US$23 billion per year,[82]with rotavirus alone resulting in estimated costs of US$1 billion a year.[1]

Terminology

[edit]

The first usage of "gastroenteritis" was in 1825.[83]Before this time it was commonly known astyphoid feveror "cholera morbus", among others, or less specifically as "griping of the guts", "surfeit", "flux", "colic", "bowel complaint", or any one of a number of other archaic names for acute diarrhea.[84]Cholera morbus is a historical term that was used to refer to gastroenteritis rather than specificallycholera.[85]

Other animals

[edit]

Many of the same agents cause gastroenteritis in cats and dogs as in humans. The most common organisms areCampylobacter,Clostridium difficile,Clostridium perfringens,andSalmonella.[86]A large number of toxic plants may also cause symptoms.[87]

Some agents are more specific to a certain species.Transmissible gastroenteritis coronavirus(TGEV) occurs in pigs resulting in vomiting, diarrhea, and dehydration.[88]It is believed to be introduced to pigs by wild birds and there is no specific treatment available.[89]It is not transmissible to humans.[90]

See also

[edit]

References

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Notes

[edit]
  • Dolin R, Mandell GL, Bennett JE, eds. (2010).Mandell, Douglas, and Bennett's principles and practice of infectious diseases(7th ed.). Philadelphia: Churchill Livingstone/Elsevier.ISBN978-0-443-06839-3.
[edit]
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