Sulodexide
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| Routes of administration | Oral, Subcutaneous, Intravenous, Intramuscular |
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Sulodexide,traded asAterina,is a highly purified mixture ofglycosaminoglycanscomposed ofheparan sulfate(80%) anddermatan sulfate(20%).
Pharmacology
[edit]The low molecular weight of both sulodexide fractions allows for extensive oral absorption compared to unfractionatedheparin.The pharmacological effects of sulodexide differ substantially from other glycosaminoglycans and are mainly characterized by a prolonged half-life and reduced effect on global coagulation and bleeding parameters.[1]Due to the presence of both glycosaminoglycan fractions, sulodexide potentiates the antiprotease activities of bothantithrombin IIIandheparin cofactor IIsimultaneously.[2]
Uses
[edit]Clinically, sulodexide is used for the prophylaxis and treatment of thromboembolic diseases. Research has also demonstrated the beneficial effects of sulodexide in animal models ofreperfusion injury[3]and the treatment ofdiabetic nephropathy.[4][5][6] In combination withmelatonin,sulodexide has been shown to be a viable treatment option for patients suffering from central or sensorineuraltinnitus.[7][8]There have also been positive results in treating tinnitus using sulodexide as a monotherapy.[9]Sulodexide has also been effectively used in the treatment ofchronic venous disease.[10]
References
[edit]- ^Lauver DA, Lucchesi BR (2006)."Sulodexide: a renewed interest in this glycosaminoglycan".Cardiovascular Drug Reviews.24(3–4): 214–226.doi:10.1111/j.1527-3466.2006.00214.x.hdl:2027.42/73024.PMID17214598.
- ^Harenberg J (January 1998). "Review of pharmacodynamics, pharmacokinetics, and therapeutic properties of sulodexide".Medicinal Research Reviews.18(1): 1–20.doi:10.1002/(SICI)1098-1128(199801)18:1<1::AID-MED1>3.0.CO;2-4.PMID9436179.S2CID26366651.
- ^Lauver DA, Booth EA, White AJ, Poradosu E, Lucchesi BR (February 2005). "Sulodexide attenuates myocardial ischemia/reperfusion injury and the deposition of C-reactive protein in areas of infarction without affecting hemostasis".The Journal of Pharmacology and Experimental Therapeutics.312(2): 794–800.doi:10.1124/jpet.104.075283.PMID15365091.S2CID9865911.
- ^Achour A, Kacem M, Dibej K, Skhiri H, Bouraoui S, El May M (2005). "One year course of oral sulodexide in the management of diabetic nephropathy".Journal of Nephrology.18(5): 568–574.PMID16299683.
- ^Gambaro G, Venturini AP, Noonan DM, Fries W, Re G, Garbisa S, et al. (September 1994)."Treatment with a glycosaminoglycan formulation ameliorates experimental diabetic nephropathy".Kidney International.46(3): 797–806.doi:10.1038/ki.1994.335.PMID7527876.
- ^Skrha J, Perusicová J, Pont'uch P, Oksa A (October 1997). "Glycosaminoglycan sulodexide decreases albuminuria in diabetic patients".Diabetes Research and Clinical Practice.38(1): 25–31.doi:10.1016/S0168-8227(97)00076-4.PMID9347243.
- ^Neri G, Baffa C, De Stefano A, Poliandri A, Kulamarva G, Di Giovanni P, et al. (2009). "Management of tinnitus: oral treatment with melatonin and sulodexide".Journal of Biological Regulators and Homeostatic Agents.23(2): 103–110.PMID19589291.
- ^Neri G. De Stefano A. Baffa C. Kulamarva G. Di Giovanni P. Petrucci G. Poliandri A. Dispenza F. Citraro L. Croce A., "Treatment of central and sensorineural tinnitus with orally administered Melatonin and Sulodexide: personal experience from a randomized controlled study."Acta Otorhinolaryngologica Italica.29(2):86-91, 2009 Apr.
- ^El Beaino M, McCaskey MK, Eter E (June 2018). "Sulodexide Monotherapy in Chronic Idiopathic Subjective Tinnitus: A Randomized Controlled Trial".Otolaryngology–Head and Neck Surgery.158(6). SAGE Publications: 1107–1112.doi:10.1177/0194599818767618.PMID29712507.S2CID14058842.
- ^Andreozzi GM (April 2012). "Sulodexide in the treatment of chronic venous disease".American Journal of Cardiovascular Drugs.12(2): 73–81.doi:10.2165/11599360-000000000-00000.PMID22329592.S2CID23046029.
External links
[edit]- sulodexideat the U.S. National Library of MedicineMedical Subject Headings(MeSH)
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