TIE1
| tyrosine kinase with immunoglobulin-like and EGF-like domains 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | TIE1 | ||||||
| Alt. symbols | TIE, JTK14 | ||||||
| NCBI gene | 7075 | ||||||
| HGNC | 11809 | ||||||
| OMIM | 600222 | ||||||
| RefSeq | NM_005424 | ||||||
| UniProt | P35590 | ||||||
| Other data | |||||||
| EC number | 2.7.1.112 | ||||||
| Locus | Chr. 1p34-p33 | ||||||
| |||||||
Tyrosine kinase with immunoglobulin-like and EGF-like domains 1also known asTIE1is anangiopoietin receptorwhich in humans is encoded by theTIE1gene.[5]
Function
[edit]TIE1 is a cell surface protein expressed exclusively inendothelialcells, however it has also been shown to be expressed in immaturehematopoietic cells[6]and platelets.[7]TIE1 upregulates thecell adhesion molecules(CAMs)VCAM-1,E-selectin,andICAM-1through ap38-dependent mechanism. Attachment ofmonocytederived immune cells to endothelial cells is also enhanced by TIE1 expression. TIE1 has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such asatherosclerosis.[8]
See also
[edit]References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000066056–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000033191–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Partanen J, Armstrong E, Mäkelä TP, Korhonen J, Sandberg M, Renkonen R, Knuutila S, Huebner K, Alitalo K (April 1992)."A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains".Molecular and Cellular Biology.12(4): 1698–707.doi:10.1128/mcb.12.4.1698.PMC369613.PMID1312667.
- ^Rodewald HR, Sato TN (January 1996). "Tie1, a receptor tyrosine kinase essential for vascular endothelial cell integrity, is not critical for the development of hematopoietic cells".Oncogene.12(2): 397–404.PMID8570217.
- ^Tsiamis AC, Hayes P, Box H, Goodall AH, Bell PR, Brindle NP (2000). "Characterization and regulation of the receptor tyrosine kinase Tie-1 in platelets".Journal of Vascular Research.37(6): 437–42.doi:10.1159/000054075.PMID11146396.S2CID43509019.
- ^Chan B, Yuan HT, Ananth Karumanchi S, Sukhatme VP (July 2008). "Receptor tyrosine kinase Tie-1 overexpression in endothelial cells upregulates adhesion molecules".Biochemical and Biophysical Research Communications.371(3): 475–9.doi:10.1016/j.bbrc.2008.04.091.PMID18448073.
External links
[edit]- Receptor,+TIE-1at the U.S. National Library of MedicineMedical Subject Headings(MeSH)
