TNF receptor associated factor
(Redirected fromTRAF)
TNF receptor associated factors(TRAFs) are a family ofproteinsprimarily involved in the regulation ofinflammation,antiviralresponses andapoptosis.[1]
Currently, seven TRAF proteins have been characterized inmammals:TRAF1,TRAF2,TRAF3,TRAF4,TRAF5,TRAF6andTRAF7.
Except for TRAF7, these proteins share a relatively conservedsecondary structure,including a namesakeC-terminalTRAF domain that mediates interactions with other signaling components such as the transmembraneTNF receptorsandCD40.
See also
[edit]References
[edit]- ^Inoue J, Ishida T, Tsukamoto N, Kobayashi N, Naito A, Azuma S, Yamamoto T (January 2000). "Tumor necrosis factor receptor-associated factor (TRAF) family: adapter proteins that mediate cytokine signaling".Exp. Cell Res.254(1): 14–24.doi:10.1006/excr.1999.4733.PMID10623461.
External links
[edit]- TRAF+Proteinsat the U.S. National Library of MedicineMedical Subject Headings(MeSH)
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