Tametraline
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| Formula | C17H19N |
| Molar mass | 237.346g·mol−1 |
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Tametraline(CP-24,441) is the parent of a series of chemical compounds investigated atPfizerthat eventually led to the development ofsertraline(CP-51,974-1).[1]
Sertraline has been called "3,4-dichloro-tametraline". This is correct but it is an oversimplification in the sense that sertraline is theS,S-isomer whereas tametraline is the 1R,4S-stereoisomer.
1R-Methylamino-4S-phenyl-tetralinis a potent inhibitor of norepinephrine uptake in rat brain synaptosomes,[2]reversesreserpineinduced hypothermia in mice, and blocks uptake of3H-Norepinephrineinto rat heart.[3]
Tametraline is anorepinephrine-dopamine reuptake inhibitor.[4]
Indatralineis an indanamine homolog of tetralin-based tametraline, although in the case of indatraline the product is pm-dichlorinated.
Law
[edit]Finland
[edit]Tametraline is completely unscheduled.
See also
[edit]- Cyproheptadine[4-(5H-dibenz-[a,d]cyclohepten-5-ylidine)-1-methylpiperidine]
- Dasotraline
- Desmethylsertraline
- EXP-561(1-amino-4-phenylbicyclo[2.2.2]octane)
- JNJ-7925476
- Lometraline
- Nefopam
- Sertraline
References
[edit]- ^Koe BK, Weissman A, Welch WM, Browne RG (September 1983). "Sertraline, 1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotonin".The Journal of Pharmacology and Experimental Therapeutics.226(3): 686–700.PMID6310078.
- ^Koe BK (December 1976). "Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain".The Journal of Pharmacology and Experimental Therapeutics.199(3): 649–61.PMID994022.
- ^Sarges R, Koe BK, Weissman A, Schaefer JP (December 1974). "Blockade of heart 3H-norepinephrine up-take by 4-phenyl-1-aminotetralines: implications for the active conformation of imipramine-like drugs".The Journal of Pharmacology and Experimental Therapeutics.191(3): 393–402.PMID4427286.
- ^Welch WM, Kraska AR, Sarges R, Koe BK (November 1984). "Nontricyclic antidepressant agents derived from cis- and trans-1-amino-4-aryltetralins".Journal of Medicinal Chemistry.27(11): 1508–15.doi:10.1021/jm00377a021.PMID6492080.