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Timelotem

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Timelotem
Clinical data
ATC code
  • none
Identifiers
  • 10-fluoro-3-methyl-7-thiophen-2-yl-2,4,4a,5-tetrahydro-1H-pyrazino[1,2-a][1,4]benzodiazepine
CAS Number
PubChemCID
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC17H18FN3S
Molar mass315.41g·mol−1
3D model (JSmol)
  • CN1CCN2C(C1)CN=C(C3=C2C=C(C=C3)F)C4=CC=CS4
  • InChI=1S/C17H18FN3S/c1-20-6-7-21-13(11-20)10-19-17(16-3-2-8-22-16)14-5-4-12(18)9-15(14)21/h2-5,8-9,13H,6-7,10-11H2,1H3
  • Key:ICHHTOMWWAMJQP-UHFFFAOYSA-N

Timelotemis abenzodiazepinederivative with an unusual activity profile. Unlike most benzodiazepines, timelotem has little or no activity at theGABAAreceptor,but instead acts as an atypicalantipsychoticdrug with similar pharmacology and effects to the structurally related drugclozapine.[1]It has two enantiomers, but has only been studied as the racemic mix.

See also

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References

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  1. ^Schmidt WJ, Krähling H, Ruhland M (October 1987). "Antagonism of AP-5- and amphetamine-induced behaviour by timelotem as compared with clozapine and haloperidol".Life Sciences.41(16): 1909–14.doi:10.1016/0024-3205(87)90742-9.PMID2889124.
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