Tingible body macrophage
Atingible body macrophage(TBM) is a type ofmacrophagepredominantly found ingerminal centersoflymph nodes.They contain manyphagocytized,apoptoticcells in various states of degradation, referred to astingible bodies(tingiblemeaningstainable).[2]Tingible body macrophages contain condensedchromatinfragments.[3]
TBMs are licensed (empowered) forphagocytosisbyfollicular dendritic cells(FDCs).[4]FDCs provide TBMs withMFGE8protein, which is aphosphatidylserine-binding "eat me" signal for removal ofapoptoticgerminal centerB cells.[4]
It is thought that they may play a role in downregulating the germinal center reaction by the release ofprostaglandinsand hence a reduced B-cell induction ofIL-2.[5]
Macrophages that contain debris from ingestedlymphocytesare characteristic of a reactive follicular center inbenign reactive lymphadenitis.Other accompanying signs of a benign follicular hyperplasia are well developed germinal centers with dark and light zones, in addition to numerousmitotic figures.
References
[edit]- ^Image by Mikael Häggström, MD. Reference for findings:Ali Ismail, M.B.B.S., Ziyan T. Salih, M.D."Chronic cervicitis".Pathology Outlines.
{{cite web}}:CS1 maint: multiple names: authors list (link)Last staff update: 15 December 2022 - ^Horst Ibelgaufts' COPE: Cytokines & Cells Online Pathfinder Encyclopaedia > tingible body macrophagesRetrieved on June 27, 2010
- ^MacLennan I.C.M (1994). "Germinal Centers".Annual Review of Immunology.12:117–139.doi:10.1146/annurev.iy.12.040194.001001.PMID8011279.
- ^abAguzzi A, Kranich J, Krautler NJ (2014). "Follicular dendritic cells: origin, phenotype, and function in health and disease".Trends in Immunology.35(3): 105–113.doi:10.1016/j.it.2013.11.001.PMID24315719.
- ^Smith JP, Burton GF, Tew JG, Szakal AK (1998)."Tingible body macrophages in regulation of germinal center reactions".Developmental Immunology.6(3–4): 285–294.doi:10.1155/1998/38923.PMC2276033.PMID9814602.
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