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Protein-coding gene in the species Homo sapiens
Tuftelin is an acidicphosphorylated glycoprotein found intooth enamel .In humans, the tuftelin protein is encoded by theTUFT1 gene.[5] [6] [7]
There are two kinds of enamel proteins:amelogenins and nonamelogenins. Tuftelin falls under nonamelogenins.[8]
This protein is formed for a short time duringamelogenesis .The function of tuftelins is under contention, but it is proposed that it acts to start the mineralization process of enamel duringtooth development .[9] [10]
Other significant proteins in enamel areamelogenins ,enamelins ,andameloblastins .
The human encodinggene for tuftelin (TUFT1) was cloned by Profs. Danny Deutsch and Aharon Palmon from theHebrew University -Hadassah School of Dental Medicine inJerusalem .[6]
Tuftelin has been shown tointeract withTFIP11 .[11]
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