From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Tuftelin is an acidicphosphorylated glycoprotein found intooth enamel .In humans, the tuftelin protein is encoded by theTUFT1 gene.[ 5] [ 6] It is an acidic protein that is thought to play a role in dental enamel mineralization and is implicated in caries susceptibility. It is also thought to be involved with adaptation to hypoxia, mesenchymal stem cell function, and neurotrophin nerve growth factor mediated neuronal differentiation.[ 7]
There are two kinds of enamel proteins:amelogenins and nonamelogenins. Tuftelin falls under nonamelogenins.[ 8]
This protein is formed for a short time duringamelogenesis .The function of tuftelins is under contention, but it is proposed that it acts to start the mineralization process of enamel duringtooth development .[ 9] [ 10]
Other significant proteins in enamel areamelogenins ,enamelins ,andameloblastins .
The human encodinggene for tuftelin (TUFT1) was cloned by Profs. Danny Deutsch and Aharon Palmon from theHebrew University -Hadassah School of Dental Medicine inJerusalem .[ 6]
Tuftelin has been shown tointeract withTFIP11 .[ 11]
^a b c GRCh38: Ensembl release 89: ENSG00000143367 –Ensembl ,May 2017
^a b c GRCm38: Ensembl release 89: ENSMUSG00000005968 –Ensembl ,May 2017
^ "Human PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Entrez Gene: TUFT1 tuftelin 1" .
^a b Deutsch D, Palmon A, Young MF, Selig S, Kearns WG, Fisher LW (July 1994)."Mapping of the human tuftelin (TUFT1) gene to chromosome 1 by fluorescence in situ hybridization" .Mamm. Genome .5 (7): 461–2.doi :10.1007/BF00357011 .PMID 7919663 .S2CID 20041600 .
^ "TUFT1 tuftelin 1 [Homo sapiens (human)] - Gene - NCBI" .ncbi.nlm.nih.gov .Retrieved2018-03-05 .
^ Nanci, Antonio (2017-08-15).Ten Cate's Oral Histology - E-Book: Development, Structure, and Function .Elsevier Health Sciences.ISBN 9780323485180 .
^ Deutsch D (June 1989). "Structure and function of enamel gene products".Anat. Rec .224 (2): 189–210.doi :10.1002/ar.1092240209 .PMID 2672884 .S2CID 37887565 .
^ Deutsch D, Palmon A, Fisher LW, Kolodny N, Termine JD, Young MF (August 1991)."Sequencing of bovine enamelin (" tuftelin ") a novel acidic enamel protein" .J. Biol. Chem .266 (24): 16021–8.doi :10.1016/S0021-9258(18)98510-8 .PMID 1874744 .
^ Paine, C T; Paine M L; Luo W; Okamoto C T; Lyngstadaas S P; Snead M L (July 2000)."A tuftelin-interacting protein (TIP39) localizes to the apical secretory pole of mouse ameloblasts" .J. Biol. Chem .275 (29). UNITED STATES: 22284–92.doi :10.1074/jbc.M000118200 .ISSN 0021-9258 .PMID 10806191 .
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