UGT1A3

UGT1A3
Identifiers
Aliases	UGT1A3,UDPGT, UDPGT 1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C, UGT1A3S, UDP glucuronosyltransferase family 1 member A3
External IDs	OMIM:606428;MGI:3576049;HomoloGene:86211;GeneCards:UGT1A3;OMA:UGT1A3 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q37.1 Start 233,729,042bp End 233,773,300bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 D Start 88,128,323bp End 88,146,719bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in liver right lobe of liver muscle tissue kidney small intestine duodenum colon Top expressed in right kidney human kidney granulocyte renal cortex liver duodenum lip uterus bone marrow proximal tubule More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity retinoic acid binding hexosyltransferase activity protein homodimerization activity glycosyltransferase activity glucuronosyltransferase activity protein heterodimerization activity enzyme binding UDP-glycosyltransferase activity Cellular component integral component of membrane endoplasmic reticulum membrane membrane intracellular membrane-bounded organelle endoplasmic reticulum Biological process retinoic acid metabolic process negative regulation of cellular glucuronidation cellular glucuronidation flavonoid glucuronidation xenobiotic glucuronidation negative regulation of glucuronosyltransferase activity negative regulation of fatty acid metabolic process metabolism Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 54659 22236 Ensembl ENSG00000288702 ENSMUSG00000090171 UniProt P35503 P70691 RefSeq (mRNA) NM_019093 NM_013701 RefSeq (protein) NP_061966 NP_038729 Location (UCSC) Chr 2: 233.73 – 233.77 Mb Chr 1: 88.13 – 88.15 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

UDP-glucuronosyltransferase 1-3is anenzymethat in humans is encoded by theUGT1A3gene.

This gene encodes a UDP-glucuronosyltransferase,an enzyme of theglucuronidationpathway that transforms small lipophilic molecules, such as steroids,bilirubin,hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complexlocusthat encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate firstexonsfollowed by four common exons. Four of the alternate first exons are consideredpseudogenes.Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with differentN-terminiand identicalC-termini.Each first exon encodes the substrate binding site, and is regulated by its own promoter. Substrates of this enzyme includeestrone,2-hydroxyestrone,and metabolites ofbenzo(a)pyrene.

Further reading

• Tukey RH, Strassburg CP (2000). "Human UDP-glucuronosyltransferases: metabolism, expression, and disease".Annual Review of Pharmacology and Toxicology.40:581–616.doi:10.1146/annurev.pharmtox.40.1.581.PMID10836148.
• Tukey RH, Strassburg CP (March 2001). "Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract".Molecular Pharmacology.59(3): 405–14.doi:10.1124/mol.59.3.405.PMID11179432.S2CID21500183.
• King CD, Rios GR, Green MD, Tephly TR (September 2000). "UDP-glucuronosyltransferases".Current Drug Metabolism.1(2): 143–61.doi:10.2174/1389200003339171.PMID11465080.
• Moghrabi N, Sutherland L, Wooster R, Povey S, Boxer M, Burchell B (May 1992). "Chromosomal assignment of human phenol and bilirubin UDP-glucuronosyltransferase genes (UGT1A-subfamily)".Annals of Human Genetics.56(2): 81–91.doi:10.1111/j.1469-1809.1992.tb01134.x.PMID1503396.S2CID40140345.
• Mojarrabi B, Butler R, Mackenzie PI (August 1996). "cDNA cloning and characterization of the human UDP glucuronosyltransferase, UGT1A3".Biochemical and Biophysical Research Communications.225(3): 785–90.doi:10.1006/bbrc.1996.1251.PMID8780690.
• Strassburg CP, Manns MP, Tukey RH (July 1997). "Differential down-regulation of the UDP-glucuronosyltransferase 1A locus is an early event in human liver and biliary cancer".Cancer Research.57(14): 2979–85.PMID9230212.
• Strassburg CP, Oldhafer K, Manns MP, Tukey RH (August 1997). "Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue".Molecular Pharmacology.52(2): 212–20.doi:10.1124/mol.52.2.212.PMID9271343.S2CID37098463.
• Strassburg CP, Manns MP, Tukey RH (April 1998)."Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8".The Journal of Biological Chemistry.273(15): 8719–26.doi:10.1074/jbc.273.15.8719.PMID9535849.
• Green MD, King CD, Mojarrabi B, Mackenzie PI, Tephly TR (June 1998). "Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3".Drug Metabolism and Disposition.26(6): 507–12.PMID9616184.
• Strassburg CP, Kneip S, Topp J, Obermayer-Straub P, Barut A, Tukey RH, Manns MP (November 2000)."Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine".The Journal of Biological Chemistry.275(46): 36164–71.doi:10.1074/jbc.M002180200.PMID10748067.
• Barbier O, Albert C, Martineau I, Vallée M, High K, Labrie F, Hum DW, Labrie C, Bélanger A (March 2001). "Glucuronidation of the nonsteroidal antiestrogen EM-652 (SCH 57068), by human and monkey steroid conjugating UDP-glucuronosyltransferase enzymes".Molecular Pharmacology.59(3): 636–45.doi:10.1124/mol.59.3.636.PMID11179460.S2CID38640331.
• Turgeon D, Chouinard S, Belanger P, Picard S, Labbe JF, Borgeat P, Belanger A (June 2003)."Glucuronidation of arachidonic and linoleic acid metabolites by human UDP-glucuronosyltransferases".Journal of Lipid Research.44(6): 1182–91.doi:10.1194/jlr.M300010-JLR200.PMID12639971.
• Zhang JY, Zhan J, Cook CS, Ings RM, Breau AP (May 2003). "Involvement of human UGT2B7 and 2B15 in rofecoxib metabolism".Drug Metabolism and Disposition.31(5): 652–8.doi:10.1124/dmd.31.5.652.PMID12695355.S2CID23434477.