UGT2B15

UGT2B15
Identifiers
Aliases	UGT2B15,HLUG4, UDPGT 2B8, UDPGT2B15, UDPGTH3, UGT2B8, UDP glucuronosyltransferase family 2 member B15
External IDs	OMIM:600069;MGI:1919023;HomoloGene:133957;GeneCards:UGT2B15;OMA:UGT2B15 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	68,670,652bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	87,074,389bp
RNA expressionpattern
	Top expressed in
	gallbladder; ; liver; ; right lobe of liver; ; gonad; ; islet of Langerhans; ; duodenum; ; mucosa of transverse colon; ; body of pancreas; ; body of stomach; ; rectum;
	Top expressed in
	left lobe of liver; ; embryo; ; lumbar subsegment of spinal cord; ; right ventricle; ; tibiofemoral joint; ; sexually immature organism; ; medial head of gastrocnemius muscle; ; lumbar spinal ganglion; ; stria vascularis; ; carotid body;
	More reference expression data
	n/a
Gene ontology
Molecular function	hexosyltransferase activity; glucuronosyltransferase activity; glycosyltransferase activity; transferase activity; retinoic acid binding; UDP-glycosyltransferase activity;
Cellular component	endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; integral component of membrane; organelle membrane; endoplasmic reticulum;
Biological process	steroid metabolic process; cellular glucuronidation; metabolism; xenobiotic metabolic process;
	Sources:Amigo/QuickGO
Orthologs
	7366
	71773
	ENSG00000277132; ENSG00000196620
	ENSMUSG00000035836
	P54855
	Q8R084
	NM_001076
	NM_152811
	NP_001067
	NP_690024
	Wikidata
View/Edit Human	View/Edit Mouse

UDP-glucuronosyltransferase 2B15is anenzymethat in humans is encoded by theUGT2B15gene.^[5]^[6]

The UGTs are of major importance in the conjugation and subsequent elimination of potentially toxicxenobioticsand endogenous compounds. UGT2B8 demonstrates reactivity withestriol.SeeUGT2B4(MIM 600067).[supplied by OMIM]^[6]

References

^^a ^b ^cENSG00000196620 GRCh38: Ensembl release 89: ENSG00000277132, ENSG00000196620–Ensembl,May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000035836–Ensembl,May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Monaghan G, Clarke DJ, Povey S, See CG, Boxer M, Burchell B (Feb 1995). "Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13".Genomics.23(2): 496–9.doi:10.1006/geno.1994.1531.PMID 7835904.
^^a ^b"Entrez Gene: UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15".

Coffman BL, Tephly TR, Irshaid YM, et al. (1990). "Characterization and primary sequence of a human hepatic microsomal estriol UDPglucuronosyltransferase".Arch. Biochem. Biophys.281(1): 170–5.doi:10.1016/0003-9861(90)90428-2.PMID 2116769.
Irshaid YM, Tephly TR (1987). "Isolation and purification of two human liver UDP-glucuronosyltransferases".Mol. Pharmacol.31(1): 27–34.PMID 3100939.
Green MD, Clarke DJ, Oturu EM, et al. (1995). "Cloning and expression of a rat liver phenobarbital-inducible UDP-glucuronosyltransferase (2B12) with specificity for monoterpenoid alcohols".Arch. Biochem. Biophys.322(2): 460–8.doi:10.1006/abbi.1995.1489.PMID 7574722.
Green MD, Oturu EM, Tephly TR (1995). "Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates".Drug Metab. Dispos.22(5): 799–805.PMID 7835232.
Chen F, Ritter JK, Wang MG, et al. (1993). "Characterization of a cloned human dihydrotestosterone/androstanediol UDP-glucuronosyltransferase and its comparison to other steroid isoforms".Biochemistry.32(40): 10648–57.doi:10.1021/bi00091a015.PMID 8399210.
Guillemette C, Lévesque E, Beaulieu M, et al. (1997)."Differential regulation of two uridine diphospho-glucuronosyltransferases, UGT2B15 and UGT2B17, in human prostate LNCaP cells".Endocrinology.138(7): 2998–3005.doi:10.1210/endo.138.7.5226.PMID 9202245.
Lévesque E, Beaulieu M, Green MD, et al. (1997). "Isolation and characterization of UGT2B15(Y85): a UDP-glucuronosyltransferase encoded by a polymorphic gene".Pharmacogenetics.7(4): 317–25.doi:10.1097/00008571-199708000-00007.PMID 9295060.
Strassburg CP, Strassburg A, Nguyen N, et al. (1999)."Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus".Biochem. J.338(2): 489–98.doi:10.1042/0264-6021:3380489.PMC1220077.PMID 10024527.
Tchernof A, Lévesque E, Beaulieu M, et al. (1999). "Expression of the androgen metabolizing enzyme UGT2B15 in adipose tissue and relative expression measurement using a competitive RT-PCR method".Clin. Endocrinol.50(5): 637–42.doi:10.1046/j.1365-2265.1999.00709.x.PMID 10468930.S2CID 43030627.
Strassburg CP, Kneip S, Topp J, et al. (2000)."Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine".J. Biol. Chem.275(46): 36164–71.doi:10.1074/jbc.M002180200.PMID 10748067.
Gsur A, Preyer M, Haidinger G, et al. (2002). "A polymorphism in the UDP-Glucuronosyltransferase 2B15 gene (D85Y) is not associated with prostate cancer risk".Cancer Epidemiol. Biomarkers Prev.11(5): 497–8.PMID 12010866.
Iida A, Saito S, Sekine A, et al. (2002)."Catalog of 86 single-nucleotide polymorphisms (SNPs) in three uridine diphosphate glycosyltransferase genes: UGT2A1, UGT2B15, and UGT8".J. Hum. Genet.47(10): 505–10.doi:10.1007/s100380200075.PMID 12376738.
Court MH, Duan SX, Guillemette C, et al. (2003). "Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9".Drug Metab. Dispos.30(11): 1257–65.doi:10.1124/dmd.30.11.1257.PMID 12386133.
Kanaya J, Takashima M, Koh E, Namiki M (2003). "Androgen-independent growth in LNCaP cell lines and steroid uridine diphosphate-glucuronosyltransferase expression".Asian J. Androl.5(1): 9–13.PMID 12646996.
Zhang JY, Zhan J, Cook CS, et al. (2003). "Involvement of human UGT2B7 and 2B15 in rofecoxib metabolism".Drug Metab. Dispos.31(5): 652–8.doi:10.1124/dmd.31.5.652.PMID 12695355.S2CID 23434477.
Tomboc M, Witchel SF (2003). "Frequencies of the D85 and Y85 variants of UGT2B15 in children and adolescent girls with hyperandrogenism".J. Pediatr. Endocrinol. Metab.16(5): 719–26.doi:10.1515/jpem.2003.16.5.719.PMID 12880121.S2CID 32217321.
Court MH, Hao Q, Krishnaswamy S, et al. (2005). "UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver".J. Pharmacol. Exp. Ther.310(2): 656–65.doi:10.1124/jpet.104.067660.PMID 15044558.S2CID 5946464.
Toide K, Umeda S, Yamazaki H, et al. (2005). "A major genotype in UDP-glucuronosyltransferase 2B15".Drug Metab. Pharmacokinet.17(2): 164–6.doi:10.2133/dmpk.17.164.PMID 15618667.
Chouinard S, Pelletier G, Bélanger A, Barbier O (2005). "Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium".Endocr. Res.30(4): 717–25.doi:10.1081/ERC-200044014.PMID 15666817.S2CID 10971899.

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[refGRCh38Ensembl-1] ENSG00000196620 GRCh38: Ensembl release 89: ENSG00000277132, ENSG00000196620–Ensembl,May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035836–Ensembl,May 2017

[3] "Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7835904-5] Monaghan G, Clarke DJ, Povey S, See CG, Boxer M, Burchell B (Feb 1995). "Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13".Genomics.23(2): 496–9.doi:10.1006/geno.1994.1531.PMID 7835904.

[entrez-6] "Entrez Gene: UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15".

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References

Further reading