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Valofane

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Valofane
Clinical data
Other namesN-carbamoyl-5-methyl-2-oxo-3-prop-2-enyloxolane-3-carboxamide
ATC code
  • none
Identifiers
  • 3-allyl-N-(aminocarbonyl)-5-methyl-2-oxotetrahydrofuran-3-carboxamide
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.019.871Edit this at Wikidata
Chemical and physical data
FormulaC10H14N2O4
Molar mass226.232g·mol−1
3D model (JSmol)
  • O=C(N)NC(=O)C1(C(=O)OC(C)C1)C\C=C
  • InChI=1S/C10H14N2O4/c1-3-4-10(7(13)12-9(11)15)5-6(2)16-8(10)14/h3,6H,1,4-5H2,2H3,(H3,11,12,13,15)checkY
  • Key:LVJAHKSVOQLCEV-UHFFFAOYSA-NcheckY
☒NcheckY(what is this?)(verify)

Valofaneis asedativedrug structurally related to thebarbiturates[1]and similar drugs such asprimidone.It is metabolized once inside the body to form the barbiturateproxibarbital(proxibarbal) and is thus aprodrug.[2]

References[edit]

  1. ^Traversa U, Puppini P, Jacquot C, Vertua R (1985). "Effect of an atypical barbiturate, the 2-allophanyl-2-allyl-4-valerolactone (valofan), on exploratory behaviour and brain serotonin concentrations in mice".Journal de Pharmacologie.16(3): 279–90.PMID2415778.
  2. ^Lambrey B, Compagnon PL, Jacquot C (1981). "Pharmacokinetics of 14C-2-allophanyl-2-allyl -gamma-valero-lactone: a prodrug of proxibarbal in rats".European Journal of Drug Metabolism and Pharmacokinetics.6(3): 161–9.doi:10.1007/BF03189485.PMID6118275.S2CID10197120.