Fluocinonide
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Clinical data | |
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Trade names | Fluonex, Lidex, others[1] |
AHFS/Drugs.com | Micromedex Detailed Consumer Information |
MedlinePlus | a601054 |
Routes of administration | Topical |
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Pharmacokineticdata | |
Metabolism | Liver |
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ECHA InfoCard | 100.005.998 |
Chemical and physical data | |
Formula | C26H32F2O7 |
Molar mass | 494.532g·mol−1 |
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Fluocinonideis a potentglucocorticoidusedtopicallyas ananti-inflammatoryagent for the treatment ofskin disorderssuch aseczemaandseborrhoeic dermatitis.[3]It relievesitching,redness,dryness,crusting, scaling,inflammation,and discomfort.[3]
A common potential adverse effect is skin atrophy (thinning of the skin).[4]
In 2021, it was the 249th most commonly prescribed medication in the United States, with more than 1million prescriptions.[5][6]
Veterinary uses
[edit]Fluocinonide is used in veterinary medicine. It is a treatment for allergies in dogs.[7]Natural systemic cortisol concentrations can be suppressed for weeks after one week of topical exposure.[8]
References
[edit]- ^"Fluocinonide Topical".MedlinePlus Drug Information.U.S. National Library of Medicine.
- ^"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)".nctr-crs.fda.gov.FDA.Retrieved22 October2023.
- ^ab"Fluocinonide Topical: MedlinePlus Drug Information".medlineplus.gov.Retrieved16 November2022.
- ^Jablonska S, Groniowska M, Dabroswki J (February 1979). "Comparative evaluation of skin atrophy in man induced by topical corticoids".The British Journal of Dermatology.100(2): 193–206.doi:10.1111/j.1365-2133.1979.tb05561.x.PMID154921.S2CID30656827.
- ^"The Top 300 of 2021".ClinCalc.Archivedfrom the original on 15 January 2024.Retrieved14 January2024.
- ^"Fluocinonide - Drug Usage Statistics".ClinCalc.Retrieved14 January2024.
- ^Dog Allergies.Squidoo(Report).
- ^Zenoble RD, Kemppainen RJ (September 1987). "Adrenocortical suppression by topically applied corticosteroids in healthy dogs".Journal of the American Veterinary Medical Association.191(6): 685–688.PMID2824410.