Von Graefe's sign
| Von Graefe's sign | |
|---|---|
| Differential diagnosis | exophthalmic goiter |
Von Graefe's signis the lagging of the uppereyelidon downward rotation of theeye,indicatingexophthalmicgoiter(Graves' disease).[1]It is a dynamic sign, whereaslid lagis a static sign which may also be present in cicatricial eyelid retraction or congenital ptosis.
A pseudo Graefe's sign (pseudo lid lag) shows a similar lag, but is due to aberrant regeneration of fibres of theoculomotor nerve(III) into the elevator of the upper lid.[2]It occurs inparamyotonia congenita.[3] A pseudo Graefe's sign is most commonly manifested in just one eye but can occasionally be observed in both. The reason only one eye is affected is not yet clear.
See also[edit]
- Albrecht von Gräfe
- Boston's sign
- Griffith's sign
- Graves orbitopathy
- Hyperthyroidism,as lid lag may be in hyperthyroid patients lacking Graves' disease.
References[edit]
- ^Cline D; Hofstetter HW; Griffin JR.Dictionary of Visual Science.4th ed. Butterworth-Heinemann, Boston 1997.ISBN0-7506-9895-0
- ^Definition: pseudo-Graefe sign from Online Medical Dictionary
- ^Fowler, Timothy J.; John W. Scadding (2003).Clinical Neurology 3rd ed.p. 145.ISBN0-340-80798-9.
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