Xg antigen system
(Redirected fromXG antigen system)
| Xg blood group | |
|---|---|
 Interpretation of antibody panel to detect patient antibodies towards the most relevanthuman blood group systems,including Xg. | |
| Identifiers | |
| Symbol | XG |
| Alt. symbols | PBDX |
| NCBI gene | 7499 |
| HGNC | 12806 |
| RefSeq | NM_175569 |
| Other data | |
| Locus | Chr. Xp22.32 |
TheXG antigenis ared blood cellsurfaceantigendiscovered in 1962.[1]by researchers at theMRC Blood Group Unit.[2]
The PBDX gene that encodes theantigenis located on theshort armof theX chromosome.[3][4]Since males normally have one X chromosome they are consideredhemizygotes.Since women have two copies of the gene and could beheterozygoticfor the presence or absence of the functioning gene they could (through the process oflyonisation)expressthe functioningproteinon just some of their red blood cells.[citation needed]
Frequency
[edit]| Population frequencies ofXa[5] | ||||||
|---|---|---|---|---|---|---|
| Population | Sample N |
Xg % | ||||
| Australian Aborigines | 352 | 79 | ||||
| Chinese, mainland | 171 | 60 | ||||
| North Europeans | 5,388 | 66 | ||||
| Indians, Bombay | 100 | 65 | ||||
| Israelis | 201 | 66 | ||||
| American Indians | 308 | 77 | ||||
| New-Guineans | 263 | 85 | ||||
| New York's Afro-Americans | 219 | 55 | ||||
| Sardinians | 322 | 76 | ||||
| Taiwan Chinese | 178 | 53 | ||||
| Taiwan Aborigines | 164 | 38 | ||||
References
[edit]- ^Tippett P, Ellis NA (October 1998). "The Xg blood group system: a review".Transfus Med Rev.12(4): 233–57.doi:10.1016/S0887-7963(98)80001-1.PMID9798268.
- ^Mann, J. D., Cahan, A., Gelb, A. G., Fisher, N., Hamper, J., Tippett, P., Sanger, R., Race, R. R A sex-linked blood group. Lancet. 1962;279:8.
- ^Ellis NA, Tippett P, Petty A, et al. (November 1994). "PBDX is the XG blood group gene".Nat. Genet.8(3): 285–90.doi:10.1038/ng1194-285.PMID7533029.S2CID36695727.
- ^LINDSTEN J, FRACCARO M, POLANI PE, HAMERTON JL, SANGER R, RACE RR (February 1963). "Evidence that the Xg blood group genes are on the short arm of the X chromosome".Nature.197(4868): 648–9.Bibcode:1963Natur.197..648L.doi:10.1038/197648a0.PMID13930842.S2CID4209911.
- ^Harrison et al. (1977): Human biology – An introduction to human evolution, variation, growth and ecology. Oxford University Press, Oxford,ISBN978-0-19-857165-0.
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